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With diverse crowns, beautiful flowers, colorful fruits, and leaves of different colors in the four seasons, Sorbus L. has a very high ornamental value in landscape. The genus is also one difficult taxa for taxonomic research arising from the combined effects of hybridization, polyploidy and apomixis. In this study, the specimens preserved in National Plant Specimen Resource Center and the database of Global Plants were retrieved and carefully sorted out. Some key information such as herbaria, collectors, collecting sites, collection time were analyzed concretely to understand the collection sites and the distribution center of wild germplasm resources of Sorbus in China and construct the database of Sorbus in China, so as to provide references for the first general survey and collection of forest and grass germplasm resources in China. On the basis of clarifying the distribution range and habitat of Sorbus plant resources, we found that the species of Sorbus in China are the most abundant in the world and Sorbus species are mostly distributed in high-altitude areas. Especially, more than half of Sorbus species are distributed in the mountainous area of southwestern China, and multiple ploidy coexists in this area, which creates unique conditions for hybridization. Is it the key factor of rich species diversity of this genus? With this, the research status of Sorbus plants were further summarized, the problems existing in the study of molecular system biology, conservation biology, phytochemistry and resource development and utilization were pointed out, and the key issues to be paid attention to in the future research of Sorbus were put forward. Suggestions for future research on Sorbus were as follows:(1)We should focus on the study of process of hybridization on the basis of a solid phylogenetic framework;(2)Based on the comprehensive investigation of the wild germplasm resources of Sorbus in China,, we should select the species with high ornamental value and study the molecular regulatory mechanisms of the response of Sorbus species to high-temperature stress in the summer in the low altitude areas by using the latest molecular biology techniques and methods, so as to provide a theoretical basis for the introduction and acclimatization of high-altitude species. [ABSTRACT FROM AUTHOR]

Wireless communication and mobile application put forward higher requirement for mobile RFID authentication. Aiming at the security and efficiency problem of the existing authentication protocol, this paper proposed a new mobile RFID high-efficiency authentication protocol. The protocol protected the security of information transmission by using arithmetic operation, bit-wise operations, permutation and combination of bits data. It defended the illegal attack by adversary through the progressive verification of random number by database and mobile reader, as well as bundled verification by the tag. For one thing, as the communication entity performed light-weight operations, the amount of calculation was greatly reduced. For another, as the communication entity initially verified the authenticity and legitimacy of random data in time, it reduced time of the invalid authentication. These two points showed that the protocol can improve the authentication efficiency. This paper proved the correctness of the protocol using GNY logic formal language. Analysis results show that the protocol can resist different types of attacks. Simulation results show that the protocol has high authentication efficiency as compared with similar mobile RFID authentication protocols. The protocol has better application value. [ABSTRACT FROM AUTHOR]

Aiming at the problem that isolation forest is unreliable in the face of high-dimensional data by randomly selecting attributes, this paper proposed an improved anomaly detection algorithm high contrast subspace isolation forest (HiForest). Firstly, this algorithm selected the subspace with high contrast value based on the deviation between the edge probability and the joint probability of each attribute in the subspace. After that, the algorithm constructed isolation trees which had a stronger ability to isolate outliers in the relevant subspace. Finally, the algorithm integrated these isolation trees into isolation forest, and obtained the anomaly score by traversing the average path length of data points in the isolation forest. Compared with traditional anomaly detection algorithms, the experimental results based on the ODDS database show that the HiForest algorithm improves the AUC, accuracy, recall rate significantly. Therefore, HiForest algorithm is an anomaly detection algorithm suitable for high-dimensional datasets with higher detection accuracy. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Frontiers of Computer Science & Technology is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In this paper, SSR sites were screened from the sheep expression sequence tag in NCBI system (EST) database by SSR Finder software and MISA technology, and sheep EST-SSR fluorescent primers were designed using Primer 3.0 to differentiate the products of Ningxia Tan lamb, Xinjiang fine-wool sheep meat and Tibetan lamb. Experiments were PCR amplified using liver DNA from three sheep as templates for designed EST-SSR primers and detected SSR typing using capillary electrophoresis. The results showed that the fluorescent primers p2105.1 :248-559, p2025.1 : 896-1059 and p2104.1:704-1015 designed by EST-SSR labeling showed good specificity in Ningxia Tan mutton, Xinjiang fine lamb and Tibetan mutton, indicating that the distinction of three sheep varieties was achieved. This study accurately judged the varieties of three pure-bred mutton through EST-SSR marker technology science, which was of important significance for the development and utilization of sheep genetic resources, variety identification and rich molecular marker types. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　We aimed to explore the anti-inflammatory molecular mechanism of Xijiao Dihuang Decoction combined with Yinqiao Powder (XDY) in macrophages infected with influenza virus. Methods　Genes related to human macrophages infected by influenza virus PR8 were screened by the gene chip published in the GEO database. The intersection of the active components of XDY and the related differential genes of human macrophages infected by influenza virus PR8 was input into the STRING database to obtain the interaction relationship between target proteins. The core target was obtained according to the degree of protein interaction. The protein-protein interaction network was visualized with Cytoscape 3. 7. 2 software, and topology analysis was performed. The Metascape database was used for Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis. Macrophages J774A. 1 were divided into the normal group, the model group(influenza virus PR8 infection), and the XDY group (PR8 + 162. 5 mg/ L XDY) and treated for 24 h. The mRNA levels of Toll-like receptor 4(TLR4), myeloid differentiation factor 88(MyD88), TNF receptor-associated factor 6(TRAF6), tumor necrosis factor-α(TNF-α), and interleukin-6(IL-6) were detected by real-time PCR; nuclear factor-κB(NF-κB) translocation was detected by immunofluorescence; and the levels of TNF-α and IL-6 in the supernatant were detected by ELISA. Results In total, 104 common targets were obtained by analyzing the intersection of the differentially expressed genes in the PR8 and XDY groups. Pathway enrichment analysis showed that the effects of XDY on influenza may be mediated by the TLR4/NF-κB pathway. PCR result showed that compared with the model group, the mRNA levels of TLR4, MyD88, TRAF6, TNF-α, and IL-6 were lower in the XDY group (P <0. 01). Immunofluorescence result showed that compared with the model group, the nuclear localization of NF-κB in the XDY group was decreased, and the nuclear-cytoplasmic ratio was also decreased (P<0. 01). ELISA result showed that compared with the model group, the levels of TNF-α and IL-6 in the supernatant in the XDY group were decreased (P<0. 01). Conclusion　Xijiao Dihuang Decoction combined with Yinqiao Powder can regulate the TLR4/NF-κB pathway to reduce the inflammatory response in macrophages infected with influenza virus. [ABSTRACT FROM AUTHOR]

The experiment was to screen the shared DEGs of important brain tissues related to heat stress in broilers and explore their molecular mechanisms. Two sets of gene chip data sets of chicken brain and hypothalamus processed by heat stress were obtained from GEO database, and bioinformatics data were mined again. The results showed that 32 DEGs shared by important brain tissues related to heat stress were screened, including 27 significantly up-regulated genes and five significantly down-regulated genes. Through the analysis of GO and KEGG, the above genes are mainly involved in seveen biological processes and three KEGG pathways. Used STRING database and Cytoscape software to construct protein interaction network, there were 16 nodes and 102 proteins interacting. The first to seventh genes were screened as differentially expressed up-regulated genes due to GC, FGG, FGA, FGB, PLG, APOB and FABP1. The study indicates that sharing DEGs may be related to damage and pathogenesis of different tissues or organs in broilers during heat stress. [ABSTRACT FROM AUTHOR]

Objectives The very long baseline interferometry(VLBI) global observing system (VGOS) is a new generation of geodetic VLBI system which is equipped with broadband receiver and fast slewing antenna in order to achieve very high accuracy for measuring station coordinates, source positions as well as Earth rotation. Within the framework of the international VLBI service (IVS) for geodesy and astrometry, the first UT1 observing session was conducted using the VGOS stations at Kokee in USA and Wettzell in Germany, with a goal to validate VGOS data processing pipeline and estimate UT1 parameters. Methods The raw data were correlated at Shanghai VLBI correlator, followed by post-correlation processing and data analysis. The UT1 measurement results were derived and compared using VGOS database files produced from Shanghai correlator and the other correlator. Moreover, VGOS results were compared with those from the parallel UT1 session, which was conducted in the same time span using co-located legacy S/X-band stations. Results The UT1 estimation results obtained from Shanghai correlator output agree very well with those from the other correlator. The UT1 formal error obtained from VGOS observations is about 7 μs, approximately 2 times lower than the UT1 formal error obtained from the parallel legacy S/X-band observations. Conclusions VGOS system has the capability to obtain better UT1 measurement results than the legacy S/X-band system. The data processing pipeline established at Shanghai VLBI correlator has been validated and laid a foundation for regular VGOS data correlation in the near future. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To explore and evaluate the risk of adverse drug events (ADE) induced by new antiepileptic drug pirampanide based on Food and Drug Administration Adverse Event Reporting System (FAERS) database, so as to provide reference for clinical safe drug use. METHODS: Data of 37 quarters (from the first quarter of 2013 to the first quarter of 2022) in the FAERS database were mined by the ratio imbalance method. ADE reports of pirampanide that met the risk signal detection criteria were extracted and analyzed, and compared with the drug instructions to discover new ADE and analyze its rules. RESULTS: A total of 17 112 reports of perampanel-associated ADE were extracted. ADE with high reporting frequency and strong signal, which were not marked in the drug instructions, were mainly distributed in nervous system diseases, multiple drug resistance, congenital diseases, decreased anticoagulant effect and metabolic and nutritional diseases. CONCLUSIONS: More attention should be paid to the adverse drug reactions of nervous system when using pirampanide in clinical practice. For special patients, the status should be evaluated, and the optimal drug dose should be explored to ensure the medication safety of patients through individualized treatment. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To systematically evaluate the efficacy and safety of dupilumab in the treatment of adults with moderate to severe atopic dermatitis, so as to provide evidence-based reference for clinical treatment. METHODS: PubMed, Embase, the Cochrane Library and CNKI were retrieved to collect the randomized controlled trial of dupilumab in the treatment of adults with moderate to severe atopic dermatitis (the study group received dupilumab, while the control group was given placebo). The retrieval time was from the establishment of the database to Jun. 2022. RevMan 5. 3 software was used for Meta-analysis. RESULTS: Totally 10 randomized controlled trials were enrolled, including 3 383 patients. Proportion of patients in the study group with eczema area and severity index ≥ 75% of baseline remission (EASI75) were significantly higher than control group (total: RR = 3. 01,95%CI = 2. 62- 3. 46, P<0. 000 01; 300 mg, qw: RR = 2. 91, 95%CI = 2. 38-3. 55, P<0. 000 01; 300 mg, q2w: RR = 3. 16,95%CI = 2. 56-3. 89, P<0. 000 01), proportion of patients in the study group with eczema area and severity index ≥50% of baseline remission (EASI50) were significantly higher than control group (total: RR = 2. 43, 95%CI = 2. 24-2. 64, P< 0. 000 01; 300 mg, qw: RR = 2. 32, 95%CI = 2. 09-2. 59, P<0. 000 01; 300 mg, q2w: RR = 2. 58, 95%CI = 2. 27- 2. 93, P<0. 000 01), with statistically significant differences. Meanwhile, compared with the proportion of patients in the study group with IGA score of 0 or 1 points (clear or almost clear), the proportion of patients in the study group whose score of pruritus index (NRS) decreased by more than 3 points and other six effectiveness indicators, the study group was significantly better than that of control group, with statistically significant differences (P<0. 05). Through the comparative analysis of 300 mg qw and 300 mg q2w, there was no significant difference in each effectiveness index between two administration methods (P>0. 05). In terms of safety, the incidence of serious adverse reactions and skin allergy in the study group was significantly lower than that in the control group, and the incidence of injection site reaction, headache and oral herpes in the study group was significantly higher than that in the control group, with statistically significant differences (P<0. 05). There was no significant difference in the incidence of total adverse drug reactions, upper respiratory tract reaction and other safety indicators between the study group and the control group (P>0. 05). There was no significant difference between 300 mg qw and 300 mg q2w in various safety indicators (P> 0. 05). CONCLUSIONS: The efficacy of dupilumab in the treatment of adults with moderate to severe atopic dermatitis is significant, and the adverse drug reactions are mild and tolerable. [ABSTRACT FROM AUTHOR]

Based on the grain price data in the grain price database of The Qing Dynasty edited by Mr. Wang Yejian, this paper investigates the grain price fluctuation of the 12 prefectural governments in Shaanxi during the Qianlong Dynasty. The research shows that during the reign of Emperor Qianlong, the fluctuation of grain price in Shaanxi province was mainly influenced by natural disasters, which stimulated the rise of grain price. The war was also the key factor that led to the drastic fluctuation of grain prices in Shaanxi in a short period. Especially, in the process of the qing government’s unification of Xinjiang, in order to supply military grain, shaanxi actively purchased and allocated military grain, which made the fluctuation of grain prices in Shaanxi obvious. At the same time, by using the analysis method of wheat price variation coefficient and correlation coefficient in Shaanxi during the Reign of Emperor Qianlong, it is concluded that the integration degree of north Shaanxi and Guanzhong region is high, but the integration degree of Shaanxi as a whole is low. [ABSTRACT FROM AUTHOR]

Objective To explore research status and hot trends of DMED through CiteSpace-based analysis of the published domestical literatures in the past 40 years. Methods The related literatures of DMED from January 1976 to June 2022 were collected from CNKI, Wanfang database, VIP database and China biomedical literature database. The amount of papers, authors t institutions, keywords and other information were analyzed using CiteSpace knowledge map. Results A total of 818 literatures were included. The number of DMED-related documents showed an unstable upward trend. The author and organization analysis showed that Dai Yutian (Gulou Hospital Affiliated to Nanjing University Medical College, 15 articles） and Liu Jihong (Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, 12 articles） were found to be the main teams in this field, moreover formed the core author and core team. Keyword analysis demonstrated that the main research direction focused on the mechanism and treatment of DMED. T2DM, animal models, testosterone, oxidative stress, eNOS, PDE5I, adipose stem cells, gene therapy, traditional Chinese medicine and other research hotspots. Conclusion By CiteSpace analysis, we obtain an in-depth understanding of the research status of DMED for the first time. These findings will be helpful to clarify the research structure and cutting-edge trends in this field, and provide references for future research directions. [ABSTRACT FROM AUTHOR]

Objective To assess the relationship between erectile dysfunction (ED) and the risk of prostate cancer (PCa) using Meta-analysis. Methods A complete search of PubMed, Web of Science, Ovid MEDLINE, Embase, Cochrane Library, CNKI and Wanfang Database were performed to obtain eligible studies on the relationship between ED and the risk of PCa published up to 10 July 2022. Two authors independently selected the eligible publications, evaluated their quality, and extracted relevant information, followed by a meta-analysis with the software STATA 12.0. Results Nineteen studies involving 19,997 Cases were obtained for meta-analysis. The risk of PCa in the peoples with ED was 1.75 times higher than that in peoples without ED (OR = 1.75, 95% CI 1.19-2.58, P < 0.001). The level of serum prostate specific antigen (PSA) in ED peoples was higher than that in peoples without ED (SMD =0.04, 95% CI -0.01 to 0.08, P =0.674), and the difference was not statistically significant; Subgroup analysis showed that patients with ED were associated with risk of PCa under mean age < 65 years, evaluated using the IIEF, American, Asian, large sample sizes and cohort study subgroups (P <0.05). Patients with ED were not associated with risk of PCa under mean ageM65 years, non-IIEF scale of ED evaluation tool, European population, case-control study, or study with sample size < 1000 subgroups (P >0.05). Conclusion The data presented in the study suggest that the risk of prostate cancer is significandy increased in the ED population. [ABSTRACT FROM AUTHOR]

Objective To analyze the risk factors affecting the survival prognosis of patients with penile cancer (PC), construct a reliable predictive model and validate it. Methods We analyzed clinical data of the patients diagnosed with PC in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015. Then we applied Cox regression to screen independent influencing factors, constructed a nomogram model and assessed the predictive power of the nomogram using the receiver operating characteristic (ROC), calibration curve, receiver-operating characteristic curve (DCA) and survival curve results. Results Total of 1357 PC patients were finally enrolled in the study, including 945 in the training set and 412 in the internal validation set. In multivariate analysis f related factors were age, tumor size, marital status, Grade, N-stage, M-stage, (P < 0.05), and related factors were tumor size, Grade, T-stage, N-stage, M-stage, (P < 0.05). Combining the above factors, we respectively constructed prognostic nomograms at 1 year, 3 years, 5 years and 8 years. In OS and CSS, N-stage showed the greatest impact on the poor prognosis of PC patients. The ROC curve, calibration curve, DCA curve and survival curve indicated that our model had better predictive accuracy and clinical utility. Conclusions The predictive model developed in this study based on the SEER database was able to better predict the prognosis of PC patients. [ABSTRACT FROM AUTHOR]

Grape (Vitis vinifera L.) transcriptomes have been extensively profiled in different tissues, at various developmental stages, under biotic or abiotic stresses, and other conditions. However, there is still no user-friendly tool to explore these precious data. A total of 1 019 microarray sample data were downloaded from the National Center for Biotechnology Information Gene Expression Omnibus database (NCBI GEO). Weighted gene correlation network analysis (WGCNA) was conducted. Forty-one gene co-expression modules were identified. Module functional annotation suggested that these modules performed different functions and were associated with experimental conditions ／ phenotypes. Hub genes, which bear important functions, were screened based on intramodule connectivity. Module genes with unknown functions were annotated according to the "guilt-by-association" rationale. Finally, a web tool VitisMod was developed as a new resource for grape gene function investigation. VitisMod is freely available at http: ／ ／ bioinformatics.fafu. edu.cn ／ grape. [ABSTRACT FROM AUTHOR]

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Copyright of Practical Oncology Journal is the property of Journal of Practical Oncology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To evaluate the association between the expression of NF-kB inhibitor alpha (NFKBIA) gene and the prognosis and immune infiltration of the tumor microenvironment in patients with skin cutaneous melanoma (SKCM). Methods: GEPIA2 database was used to analyze the differential expression of NFKBIA in SKCM tissues and normal skin tissues. GEPIA2 and Ualcan databases were utilized to analyze the association between NFKBIA expression and SKCM prognosis. TIMER and TISIDB were used to investigate the correlation between NFKBIA and tumor-infiltrating lymphocytes (TIL) and immune regulator genes in SKCM. The association between NFKBIA and subsets of SKCM cells as well as their functional states were analyzed at single-cell level in TISCH and Cancer SEA databases. The paraffin embedded tissues from 14 SKCM patients preserved in Jingmen No.2 People's Hospital were obtained for this study, and immunohistochemical staining was used to detect the NFKBIA protein expression in SKCM tissues and para-cancerous tissues. Results: NFKBIA was lowly expressed in SKCM tissues, and SKCM patients with low NFKBIA expression had a poor prognosis (P<0.05). NFKBIA expression level was positively correlated with the infiltration of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells (all P<0.01). What's more, the expression of NFKBIA was positively correlated with TIL abundance and immunoregulatory genes (all P<0.01). NFKBIA was expressed in SKCM immune cells and positively correlated with cell differentiation and inflammation in tumor microenvironment (R=0.28, 0.23, all P<0.05). Immunohistochemical staining results demonstrated that the protein expression of NFKBIA was significantly lower in SKCM tissues than that in para-cancerous tissues (35.71% vs 85.71%, P<0.05). Conclusions: NFKBIA has a low expression in SKCM tissues, and it is correlated with immune infiltration in SKCM, which can be used as a prognostic marker and treatment target for SKCM. [ABSTRACT FROM AUTHOR]

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The void fractions of large and small bubbles, αG,L and αG,S, in a bubble column were measured by means of the DGD (Dynamic Gas Disengagement) method. The column diameter was 200 mm and the initial liquid heights H0 were 800, 1600, 2400, and 3000 mm. We dealt with heterogeneous bubbly flows with the superficial gas velocity JG from 0.06 to 0.30 m/s. Three kinds of liquids were used as the liquid phase to understand effects of the liquid viscosity on the void fractions. The following conclusions were obtained: (1) an experimental database of the void fractions of large and small bubbles was obtained at various initial liquid heights and liquid viscosities, (2) the void fractions of large and small bubbles increase with increasing JG at constant H0, (3) the void fraction of large bubbles for JG ≤ 0.10 m/s decreases with increasing H0 for H0 ≤ 2400 mm and is almost constant for H0 ≥ 2400 mm while αG,L is independent of H0 for JG ≥ 0.20 m/s, (4) the liquid viscosity does not affects αG,L, (5) the void fraction of small bubbles slightly increases at JG = 0.06 m/s, whereas it is almost constant at JG = 0.10 m/s, and decreases for JG ≥ 0.20 m/s as H0 increases, and (6) the void fraction of small bubbles decreases with increasing the liquid viscosity and dependence of αG,S on H0 is not so different. [ABSTRACT FROM AUTHOR]

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Copyright of Mycosystema is the property of Mycosystema Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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[Objectives] To develop a real-time PCR technique to identify Anopheles sinensis and Anopheles lesteri. [Methods] Samples of each species were obtained and identified using both morphological methods and gene sequencing. Positive plasmid quality control products were synthesized and cloned, and the rDNA-ITS2 sequences of A. sinensis and A. lesteri were downloaded from the NCBI database. Prime 3 software was used to design primers and probes for each species online, and the minimum detection limit, sensitivity, specificity and repeatability of the PCR method were verified. [Results] Three hundred and eighty-three mosquitoes were collected and identified to 4 species; 159 A. sinensis, 104 A. lesteri, 60 Culex pipiens quinquefasciatus and 60 Aedes albopictus. The minimum detection limit of qPCR for A. sinensis and A. lesteri was 31.5 copy/response and the linear correlation coefficient (R2) of the standard curve was 0.99. The results of a repeatability test showed that intra and inter-group coefficients of variation for A. sinensis and A. lesteri were < 2%. [Conclusion] A TaqMan probe, real-time, fluorescent, quantitative PCR method with good sensitivity and specificity was developed to identify A. sinensis and A. lesteri. [ABSTRACT FROM AUTHOR]

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