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Objective: The purpose of this study is to analyze the effect of fasciotomy on the model of high altitude extrusion rabbits, and to provide clinical basis for the treatment of extrusion injury in high altitude areas. Methods: A total of 70 healthy adult New Zealand rabbits were selected from both the experimental site and the breeding site in high altitude area Xining. Randomly divided into the experimental group of fasciotomy (60 in group A) and the control group (10 in group B without fasciotomy). After 4 hours, the two groups were decompressed at the same time. According to the time of fasciotomy after decompression, Divide group A into 6 groups (10 animals in each group), and set them as group Ⅰ (0 h), group Ⅱ (2 h), group Ⅲ (4 h), group Ⅳ (6 h), group Ⅴ (8 h), group Ⅵ (10 h); Detect biochemical indicators such as venous blood creatinine Cr, urea nitrogen BUN, blood potassium K+, lactate dehydrogenase LDH, α-hydroxybutyrate dehydrogenase HBDH in groups I-VI and B respectively; Twenty-four hours later, the myocardium, kidney and muscle of the crush syndrome rabbit model were taken for pathological section and observed under microscope 24 hours later; use SPSS19.0 statistical software for data analysis, with P<0.05 as the difference is statistically significant. Results: There was no statistically significant difference in blood BUN, Cr, K+, LDH, HBDH between group A and group B after 4 hours of squeezing (P>0.05). The data of the two groups were comparable. There was no significant difference in venous blood BUN, Cr, K+, LDH, HBDH and other biochemical indexes between group Ⅰ-Ⅵ and group B(P>0.05), and there was no statistical difference in the biochemical indicators between the subgroups at the same time point (P>0.05). Conclusion: Fasciotomy has no obvious effect on the early recovery of main organs in rabbit models with high altitude crush syndrome. [ABSTRACT FROM AUTHOR]