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Brexit is not only a major political event in Britain and an important node in the development of European integration, but also has an important impact on transatlantic relationship. Before Brexit, the UK occupied a unique position in EU-US relations, serving as a necessary bridge between the two and shaping the EU in a way that suited the US interests. However, Brexit has profoundly changed the EU, driving internal power structure shifts and policy adjustments. It will also change how EU and the US interact with each other and pose new challenges to the evolving transatlantic relationship. In the unfolding of “Great Changes Unseen in a Century”, the transatlantic relationship is undergoing profound adjustments, and Brexit has become a critical internal variable in this process. [ABSTRACT FROM AUTHOR]