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BACKGROUND: Protrusion of intervertebral disc is a complex spinal disease, which is closely related to the degeneration of intervertebral disc. Candidate genes of aggregation proteoglycan metabolic pathway may be related to the severity of protrusion of lumbar intervertebral disc.OBJECTIVE: To assess the association between single nucleotide variants and proteoglycan metabolic pathways in the severity of lumbar disc herniation in patients with chronic mechanical low back pain.METHODS: Sixty patients were classified and described. T2-weighted median sagittal lumbar MRI scans were used to assess the severity of disc herniation and degeneration. Single nucleotide variants genotyping of 20 exons of two candidate genes(proteoglycan, matrix metalloproteinase 3) of lectin metabolic pathway was performed. Age, sex, body mass index and the degree of intervertebral disc degeneration were analyzed by multiple linear regression. The trial was approved by the Ethics Committee of People’s Hospital of Dingzhou on March 1, 2015(approval No. 2015002).RESULTS AND CONCLUSION: The mutants and haplotypes of rs2272023, rs938609, rs2882676, rs698621, rs3825994, rs1042630 and rs3817428 of proteoglycan are related to the severity of lumbar disc herniation. The single nucleotide variants and its haplotype of proteoglycan are related to the severity of lumbar disc herniation. To determine the role of these important single nucleotide variants in the pathogenesis of intervertebral disc herniation, functional genetic studies are necessary. [ABSTRACT FROM AUTHOR]