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Objective: To investigate the hypoglycemic characteristics of hospitalized elderly patients with type 2 diabetes mellitus (T2DM)., Methods: From January, 2014 to December, 2015, the data of 58 565 blood measurements using a standard blood glucose monitoring system (BGMS) were collected from 1187 cases of patients with type 2 diabetes during hospitalization in the Department of Endocrinology, Guangdong General Hospital (Guangzhou, China). Stratified analyses were conducted by dividing the patients into 3 age groups, namely <45 years group (128 cases), 45-64 years group (594 cases), and ≥65 years group (465 cases). The incidence and time distribution of hypoglycemia in these patients were compared among the 3 age groups., Results: The risk of hypoglycemia increased with age. Compared with those below 45 years of age, the patients beyond or equal to 65 years had a significantly increased hypoglycemic density (0.95% vs 0.40%, P<0.001), a higher proportion of patients with hypoglycemia (28.17% vs 10.94%, P<0.001), and greater patient-days with hypoglycemia (4.48% vs 1.76%, P<0.001). In the elderly patients, hypoglycemia occurred most frequently before dawn, at which time the hypoglycemic density was 2.66% in patients ≥65 years of age, significantly higher than that in patients below 45 years (1.09%, P<0.05) and between 45 and 64 years (1.90%, P<0.05); the proportion of patients with hypoglycemia was also significantly higher in the elderly patients (14.57%) than in those below 45 years (3.77%, P<0.02) and between 45 and 64 years (9.42%, P<0.02). The proportion of patients with recurrent hypoglycemia (≥2 times) was significantly higher in patients ≥65 years (13.33%) than in younger patients (2.34% in <45 years group and 9.43% in 45-64 years group, P<0.05)., Conclusion: The hypoglycemic risk in hospitalized elderly patients with T2DM is significantly higher than that in younger patients, especially before dawn and in terms of recurrent hypoglycemia. Clinicians should develop differential blood glucose monitoring and management strategies for these elderly patients to improve the clinical safety.

Objective The study was aimed to observe the success rate of streptozotocin (STZ) induced diabetic rats by low dose repeated and large dose with a single intraperitoneal injection, and explore the ideal scheme of STZ induced diabetic rats. Methods 48 healthy male SD rats were randomly divided into 6 groups: group 1 (20 mg/kg), group 2 (30 mg/kg), group 3 (40 mg/kg), group 4 (50 mg/kg), group 5 (60 mg/kg) and group 6 (the control group) . The groups 1-3 were treated with repeated intraperitoneal injection scheme, and each injection interval time was 5 days. The groups 4 and 5 were conducted according to the single intraperitoneal injection scheme. Blood glucose was measured at the fifth day after each injection. Results The rats model of group 2, group 3, and groups 4 and 5 was successfully established after four times, two times and one time of injection, respectively. At the end of the experiment, the success rate of groups 2 to 5 was 75%, 100%, 75% and 75%, respectively. In group 1, the model has not yet succeeded after five times injection. In group 5, 2 rats died. Conclusion The single intraperitoneal injection of STZ 50 mg/kg was an economical approach to induce diabetic SD rats, which has high success rate and survival rate. [ABSTRACT FROM AUTHOR]