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To analyze the research status and development trend of ionic liquids toxicology, VOSviewer and HistCite software were used to visually analyze the countries, institutions, authors, keywords, etc. of 1 178 ionic liquids toxicology related to literatures in the Web of Science core database from 2000 to 2021. The results show that: the number of literatures in the field of ionic liquids toxicology is increasing year by year, and China is far ahead of other countries in both the number of papers published and the total citation score. At present, the paper is mainly based on team cooperation within institutions, with strong independence. Although Chinese institutions and authors rank higher in the number of papers published, their total local citation score is not outstanding. The main focus of research in ionic liquids toxicology is imidazolium. The research focuses on the evaluation of lethality and composition changes in organisms, and the construction of structure-activity relationship models between ionic liquids and organisms. The mechanism of ionic liquids toxicity and combined pollution may be the focus of future research. [ABSTRACT FROM AUTHOR]

Copyright of Mycosystema is the property of Mycosystema Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The regulation of the cell cycle is essential for maintaining normal cellular function, especially in the development of diseases such as lung cancer. The cell cycle consists of four major phases (G1, S, G2 and M phases), which are characterized by a series of precise molecular events to ensure proper cell proliferation and division. In lung cancer cells, cell cycle dysregulation can lead to disordered proliferation and increased invasiveness of cancer cells. G2 and S-phase expressed 1 (GTSE1) is a regulatory protein found in the cytoplasm of the cell, which plays a key role in the cell cycle distribution of a wide range of cancer cells and is involved in life processes such as cell proliferation and apoptosis. GTSE1 affects cell cycle progression by interacting with cyclin-dependent kinase inhibitor 1A (p21) and maintaining the stability of p21, which in turn inhibits the activity of cyclin-dependent kinase 1/2 (CDK1/2). In addition, GTSE1 is also involved in the regulation of tumor protein 53 (p53) signaling pathway. With the assistance of mouse double minute 2 homolog (MDM2), GTSE1 is able to transport p53 from the nucleus to the cytoplasm and promote its ubiquitination and degradation, thus affecting cell cycle and cell deathrelated signaling pathways. This paper reviews the expression of GTSE1 in lung cancer cells and its effects on lung cancer, as well as its potential mechanisms involved in cell cycle regulation. [ABSTRACT FROM AUTHOR]

Anaerobic digestion is another important anaerobic catabolism pathway besides lactic acid and ethanol fermentation, which is of great significance for recycling resources, maintaining the ecological balance, optimizing the energy structure, alleviating the energy crisis, and promoting the implementation of the "Carbon Peaking and Carbon Neutrality" strategy. However, such an important metabolic process has not been involved in the current textbooks and teaching of biochemistry courses, making the teaching system incomplete. The anaerobic digestion process involves many reactions and complex metabolic pathways. In order to improve the students' understanding to this process, we created a full chart of the whole anaerobic digestion process based on systemic literature review and integrated it into the classroom teaching through the BOPPPS teaching mode. It was found that the classroom teaching assisted by this metabolic chart could help students establish the structural framework of the anaerobic digestion process and enrich the knowledge system of metabolism, achieving a good teaching effect. This paper introduces the content of the metabolic pathways of anaerobic digestion and the design of the teaching process, which would facilitate the teaching reforms and perfection of textbooks for related courses, such as Biochemistry, Environmental Engineering Microbiology and New Energy Engineering.

Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Gene editing is a widely-used frontier biotechnology at present. This paper aims to explore the academic outputs, research focus and development tendency of gene editing technology in different fields, and provide reference for the development of gene editing technology.[Methods] Based on Scopus Database, gene-editing-related papers between January 2014 and June 2020 have been retrieved. SciVal analysis tool has been used to analyze the data from the perspectives of discipline distribution, output quality, collaboration and research hotspots to define the research status, existing problems and development trend of gene editing technology.[Results] The development of gene editing technology has gone through three generations of technology(ZFN,TALEN,CRISPR/Cas),and is now in the booming period of CRISPR/Cas. Gene editing technology covers 11 disciplines such as biochemistry and genetics. The overall quality of relevant academic outputs is high, field-weighted citation impact(FWCI) reaches 1.88 between January 2014 and June 2020,and the proportion of TOP 1% highly-cited publications is 5.7%,which is greatly higher than the world average level. According to total citations, the United States, China and Germany rank top 3 of top 10 countries, and Harvard University, MIT and Howard Hughes Medical Institute rank top 3 of top 10 institutions. The scholar with the most academic outputs is Zhang Feng of the Howard Hughes Medical Institute. The proportion of domestic and international collaborative research on gene editing is as high as 89.9%. Gene editing technology has a rapid upgrading speed and high research level in the field of animals, and the overall research level of gene editing technology in China remains to be improved.[Conclusions] Gene editing technology is a kind of biotechnology which can be widely used. In addition to disease diagnosis and therapy, the application prospect of CRISPR/Cas in agriculture is worth expecting, and collaborative research is the main approach and development direction of gene editing research. It can be expected that gene editing technology will provide an important boost to the rapid development of human medicine and life science, and expand the application fields of bioresearch and biotechnology. Gene editing efficiency, targeting specificity, off-target and delivery system efficiency are the key problems to be solved for the development of gene editing technology. [ABSTRACT FROM AUTHOR]

This paper analyzes the present situation and problems of online opening excellent experiment course in our country, such as few of open videos of the experimental training class, single mode, lack of systematicness and diversity of course types, and difficulty in construction, etc. In this paper, the construction of high-quality video open course of "biochemistry experiment" was treated as an example in order to elaborate the strategies of building the experiment course. It is necessary to arouse teachers' enthusiasm. The teaching content, teaching method and video style were meticulously optimized and designed to construct excellent experiment course by starting with the accurate positioning of the construction goal, the establishment of the construction team and the writing of the shooting script, outline, and lecture. The video contents of the experimental course should be elaborated by carefully shooting video materials, attaching importance to the post-production of video, and strictly checking the quality. This should provide a reference for the development and research of experimental teaching video at the background of digitalization. [ABSTRACT FROM AUTHOR]

Marine plants and their co-epiphytic microorganisms are important compositions of marine organisms, and can produce many secondary metabolites with novel structures and unique activities and have various physiological and ecological functions. The Beibu Gulf is rich in marine plant species resources. According to statistics, there are 43 species of marine plants in three phyla. This paper reviews the research progress of the secondary metabolites of marine plants and their co-epiphytic microorganisms in the Beibu Gulf since 2002. A total of 59 new compounds and 35 known active compounds were obtained from 11 species of mangrove plants and seven species of co-epiphytic microorganisms, and three new compounds and seven known active compounds were obtained from three species of seagrass plants. A total of 25 new compounds and eight known active compounds were obtained from six species of algae plants and one species of co-epiphytic microorganism, which mainly involved terpenoids, alkaloids, flavonoids and sterols, most of which had good anti-bacterial, anti-oxidation, anti-tumor, anti-inflammatory and enhancing the body immunity. Based on the above results, further research suggestions are put forward. The review provides a reference for further study and utilization of marine plants and their co-epiphytic microorganisms in the Beibu Gulf. [ABSTRACT FROM AUTHOR]

Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mammalian genomes encode numerous natural antisense transcripts (NATs). These antisense transcripts are now recognized as an important component of molecular mechanisms involved in the regulation of gene expression. NATs are particularly prevalent in the mammalian nervous system. The importance of NATs in the normal functioning of nervous system is becoming increasingly evident. They are not only involved in neuronal differentiation, myelination and ion channel regulation, but also in advanced cognitive processes, such as synapse plasticity and memory formation. This paper focuses on the potential involvement of NATs in various neurodegenerative disorders. [ABSTRACT FROM AUTHOR]

In this paper the system structure The automatic biochemistry analyzer is a necessary instrument for clinical diagnostics. First of is analyzed. The system problems description and the fundamental principles for dispatch are brought forward. Then this text puts emphasis on the modeling for the automatic biochemistry analyzer control system. The objects model and the communications model are put forward. Finally, the implementation method is designed. It indicates that the system based on the model has good performance.

This paper introduces a kind of evaluation method in pipetting performance on new fully automated biochemistry analyzers by experiments. The performance of sample pipetting volume is confirmed by dye dilution method, the performance of reagent pipetting volume and dummy volume is done by weighing method. Meanwhile, researches and comparative researches on dummy volumes in different conditions have been made, providing valuable reference for clinical applications of automatic biochemistry analyzers.

The paper focused on the reform of undergraduate experiment teaching on the strategy of "Double First-Class" construction. Reform and practice of food biochemistry experiment is considered as a case study. The present problems of content and design, characteristic and teaching methods of course of food biochemistry experiment are pointed out. The necessity of experiment teaching reform is analyzed and the teaching reform scheme is proposed. The course content of food biochemistry experiment should be closely combined with the professional characteristics of food science and engineering. Large scale comprehensive experiments based on the basic experiments are designed. More inquireexperiments and student-oriented synthetic design and innovative experiments are proposed in order to improve students’ innovative ability. Experiment education should be organically combined with scientific research. Multi-subject knowledge should be merged into food biochemistry experiment to improve students’ comprehensive ability in practice.Through the effective reform and practice on the teaching reform, the students master the principle theories, methods and skills of food biochemistry experiment, and innovational, comprehensive and practical abilities are improved. Training talents with innovative spirit, rigorous attitude toward research and cooperating spirit for the society is the ultimate aim. [ABSTRACT FROM AUTHOR]

The paper provides the design idea structure of key parts software and hardware of microprocessor of CA-1680 Biochemical Analyzer. The instrument uses the specific flow cell high properties photodiode and programmable amplifier. The 16 bit programmable A/D conversion is completed with V/F convertor and programmable counter. Logarithm conversion is completed with software. On Using these methods, the instrument has not only simpler circuit, better reliability, but also the characteristics of accuracy, precision and widely linearity.

The Folin-Wu method is one of the classic methods for blood glucose determination. It is the representative scientific research achievement of Hsien Wu, one of the most celebrated biochemists in China. This study focuses on the invention process of the Folin-Wu method by referring to the original papers of Folin and Hsien Wu and relevant second-hand historical materials. The implication of competition and cooperation in scientific community on further improvement of the Folin-Wu method is also discussed. The purpose is to evaluate the influence of the Folin-Wu method based on historical data, and to further clarify the academic contribution of Hsien Wu in the research process of this method.

Microfluidics is widely used in fields as biochemical analysis, disease diagnosis, minimally invasive surgery, and environmental monitoring. Key technologies in microfluidics are design and manufacturing of the microchannel structures, driving and control of micro-and nano-scale fluid flows, and integration and packaging of microfluidic devices and systems. In this paper, present status, applications, and prospected development of the microfluidic technology are reviewed. Meso-scale transport theory of multiphase microflows and properties of cross-scale fluids are proposed to be the hotspots in future research. [ABSTRACT FROM AUTHOR]

Although Artificial Neural Network (ANN) shows superior predictive power in the study of quantitative structure -activity relationship (QSAR) , it has been labeled as a "black box" because it provides little explanatory insight into the relative importance of the independent variables. In this paper, as an example of toxicity of 35 nitro-aromatics on fathead minnow, six methods which could give the relative contribution and/or the contribution profile of input factors were reviewed and compared. The Partial Derivative method was found to be the most useful as it gave the most complete results, followed by the Profile method that gave the contribution profile of input variables. The Perturb method allowed a good classification of input parameters as well as the Weights method that had been simplified, but these two methods lacked stability. Finally, the classical stepwise methods gave the poorest results. [ABSTRACT FROM AUTHOR]

Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)