1. Study on gait automaticity in patients with Parkinson's disease under dual-task paradigm.
- Author
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ZHANG Xin-yuan, LU Jie-wei, WANG Yue, SHU Zhi-lin, WANG Jin, CHENG Yuan-yuan, ZHU Zhi-zhong, YU Yang, YU Ning-bo, HAN Jian-da, and WU Jia-ling
- Subjects
GAIT in humans ,FUNCTIONAL status ,PSYCHOLOGY of movement ,TASK performance ,DOPAMINE ,PARKINSON'S disease ,MOTOR ability - Abstract
Objective To investigate the effect of cognitive-motor dual-task on gait automaticity in patients with Parkinson's disease (PD). Methods A total of 45 patients with primary PD in Tianjin Huanhu Hospital were selected from June 2020 to December 2021. Cognitive single task, motor single task and cognitive-motor dual-task in the "off" and "on" states of dopaminergic medication were performed. The correct number of subtractions was recorded to measure cognitive performance. A three-dimensional gait analyzer was used to extract the parameters of stride length and gait velocity, and the dual-task cost (DTC) was calculated to measure gait automaticity. Results Compared with single task, patients with PD showed slower gait velocity (t = 11.909, P = 0.000; t = 11.621, P = 0.000), shortened stride length (t = 9.027, P = 0.000; t = 9.991, P = 0.000), while there was no significant difference in the correct number of subtraction (t = 0.651, P = 0.519; t = 1.205, P = 0.234) during both "off" and "on" states. In patients with PD, the DTC of gait velocity (Z = -4.148, P = 0.000) and stride length (Z = -4.114, P = 0.000) in the "off" state was higher than that in the "on" state, while the DTC for subtraction had no significant difference (Z = -1.005, P = 0.315). The DTC of gait velocity in the "off" and "on" states of patients with PD was negatively correlated with the Mini-Mental State Examination (MMSE) score (r
s = -0.474, P = 0.000; rs = -0.461, P = 0.000), but positively correlated with Unified Parkinson's Disease Rating Scale III (UPDRS III) score (rs = 0.446, P = 0.002; rs = 0.428, P = 0.003). Conclusions Patients with PD have a significant decrease in stride length and gait velocity, and higher risk of falling when performing dual-task. Dopaminergic medication can improve the gait automaticity of patients, and cognitive decline may lead to gait automaticity disorder in patients with PD. [ABSTRACT FROM AUTHOR]- Published
- 2022
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