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Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective Analyze the current situation, hotspots and development trends of sarcopenia animal model to provide research direction and basic information for sarcopenia animal model research. Methods English literature of research on animal models of sarcopenia was retrieved from the Web of Science core data (WOS) set from 1900-01-01 to 2022-12-31. Chinese literature related to animal models of sarcopenia was retrieved from CNKI database between 1915 and 2022. The bibliometric analysis software VOSviewer was used to explore the countries, orgonizations, authors, hotspots and frontier directions in these studies. Results A total of 2 819 articles on animal models of sarcopenia were retrieved from WOS core database. The first paper was published in 1995. The United States has the largest number of animal model studies of sarcopenia with 1 105 articles. The institution with the most published articles is the University of Florida in the United States, with 69 articles. The University of Hong Kong has the highest number of publications in China, with 20 articles. American author Van Remmen H, with 50 publications, is the author of the most articles. The journal with the largest number of articles published on animal models of sarcopenia is the American journal called FASEB Journal, with 196 articles. In total, 423 articles on animal models of sarcopenia were retrieved from the CNKI database. Author LI Zhuyi has published 19 articles, and is the author of the most articles in China. The keyword co-occurrence clustering analysis of WOS literature search found that the research focus on animal model of sarcopenia can be summarized as the correlation between sarcopenia and metabolism, cytology and regenerative medicine of sarcopenia animal models, the study of sarcopenia animal models in bone, muscle, nerve and exercise therapy. The retrieval results of CNKI database revealed that the most extensive research was about on the model of denervated sarcopenia, and researches on the effects of Chinese medicine on sarcopenia were also widely reported. Through reading the full articles or abstracts of the literature, the animal models of sacopenia mainly include natural aging model, genetic modification model, high-fat diet induction model, disuse model, hormone induction model and complex sarcopenia models of other diseases. Conclusion In recent years, the study on animal model of sarcopenia has become a hotspot at home and abroad. The bibliometric analysis provides a basis for the research of animal models of sarcopenia in terms of research direction, hotspots, model animal selection, animal model making, and domestic and international communication and cooperation. [ABSTRACT FROM AUTHOR]

目的 以文献计量学为基础，应用CiteSpace软件对国内外卒中患者照顾者领域研究现状及热点问题进行分析，为深入开展该领域的研究提供参考。 方法 在中国知网和Web of Science数据库中检索从建库至2021年12月31日卒中患者照顾者领域的中英文文献，文献类型包括论著、综述、学位论文、会议论文。去除重复文献后，从发文量、作者、机构、国家、关键词等方面进行文献计量学分析。 结果 共纳入1298篇中文文献（中国知网），1763篇英文文献（Web of Science）。对于卒中患者照顾者的研究，中英文文献发表均整体呈逐年上升趋势，中国知网数据库中，发文量从2002年的4篇增至2021年的164篇；郑州大学张振香是发文量最多（48篇）的作者，郑州大学护理与健康学院（50篇）是该领域发文量最多的机构；除主题词外，“影响因素”“照顾能力”“照顾负担”“抑郁”“焦虑”“自我感受负担”等为高频关键词。在Web of Science数据库中，发文量从2009年的103篇增至2021年的201篇；美国发文量最多（565篇），约翰霍普金斯医学院的Roth在作者中发文量最多，Univ Toronto（55篇）在发文机构中居首位；“quality of life”“rehabilitation”“support”“burden”“care”“depression symptom”“survivor”等为高频关键词。 结论 国内外卒中患者照顾者领域的研究处于稳定发展阶段，发文作者、发文机构均呈现以高校和地域为中心的特点，但缺乏跨区域和跨单位合作；国内外研究热点不同，照顾负担及照顾能力的影响因素、卒中照顾者负性情绪为国内研究热点，照顾者生活质量的影响因素、照顾负担和抑郁症状、照顾者主导的康复对卒中患者的影响是国外研究热点。临床或科研工作者应加强各研究机构之间的合作，关注该领域的研究前沿和热点，提高研究深度和广度。 Abstract: Objective Based on bibliometrics, CiteSpace software was used to analyze the current research status and hot issues in the field of caregivers of stroke patients at home and abroad, to provide reference for further research in this field. Methods The relevant literature in the field of caregivers of stroke patients was retrieved from the China National Knowledge Network (CNKI) and Web of Science database from the database inception to December 31, 2021. The types of articles included clinical trials, reviews, dissertations and conference papers. Bibliometric analysis was conducted in terms of the number of papers, authors, institutions, countries and keywords. Results A total of 1298 Chinese and 1763 English literature were included. The number of these published articles is on the rise year by year both at home and abroad. In the database of CNKI, the number of published articles increased from 4 in 2002 to 164 in 2021. Zhang Zhenxiang of Zhengzhou University published the most (48 articles), and the Nursing and Health College of Zhengzhou University published the most (50 articles). In addition to the subject words, "influencing factors" "caring ability" "caring burden" "depression" "anxiety" and "self-perceived burden" were high-frequency keywords. In the Web of Science database, the number of published articles increased from 103 in 2009 to 201 in 2021, and the United States published the most (565 articles); Dr. ROTH D L of Johns Hopkins School of Medicine published the most; the Univ Toronto had the most publications (55 articles). "Quality of life" "rehabilitation" "support" "burden" "care" "depression symptom" and "survivor" were high-frequency keywords. Conclusion The research on caregivers of stroke patients at home and abroad was in a stable development stage in the recent ten years. The authors and institutions of these papers were all characterized by universities and regions, and lack of cross-regional and cross-unit cooperation. Domestic and foreign research hotspots were different. The influencing factors of caring burden and caring ability, and negative emotion of stroke caregivers were hot issues in China. The influencing factors of stroke caregivers' quality of life, caring burden and depressive symptoms of caregivers, and the influence of rehabilitation led by caregivers on stroke patients were hot issues abroad. The clinical and research workers should strengthen the cooperation among research institutions, pay attention to the research frontiers and hotspots, to improve the depth and breadth of research.

目的 探讨缺血性卒中领域孟德尔随机化研究的现状及热点，为该领域未来研究方向、药物靶点挖掘方向和探索机制提供参考。 方法 在Web of Science核心合集中检索截至2022年9月应用孟德尔随机化研究缺血性卒中的相关英文文献，用CiteSpace进行发表文献的合作网络分析（国家、机构、学者）、文献共被引情况分析、关键词共现和聚类分析。利用PharmSnap全球新药数据库查询经孟德尔随机化确定与缺血性卒中具有因果关系的生物标志物的药物研发情况。 结果 检索到文献200篇，相关研究2018年进入快速发展阶段。英国发文量为80篇、中介中心性为0.37、存在合作的国家有27个，美国发文量为63篇、中介中心性为0.10、存在合作的国家有21个，以上数据均位列所有国家的前3位，使英国和美国成为研究中心；中国发文量达到106篇，但仅与16个国家存在合作，相对较少；德国学者Rainer Malik发文20篇、文献共被引次数552次、合作学者25人，均位列第一。关键词聚类图中，IL-6是关键词聚类图中唯一被定义为聚类标签的生物因子，且炎症因素是关键词共现图中近3年研究第二多的缺血性卒中风险因素。应用孟德尔随机化确定的缺血性卒中生物标志物共12个，其中凝血因子Ⅺ和载脂蛋白α是更具潜力的药物靶点且已有相关药物进入临床研究阶段。 结论 缺血性卒中领域的孟德尔随机化研究主要在以英国为代表的欧洲国家、美国和中国开展。IL-6等炎症因素是主要研究热点，且相关研究为凝血因子Ⅺ和载脂蛋白α等生物标志物作为药物靶点提供证据。 Abstract: Objective To investigate the current status and hotspots of Mendelian randomization (MR) studies in the field of ischemic stroke (IS), and to provide reference for future research directions, digging directions of drug targets and exploring mechanism. Methods The MR related English literature in the field of IS in the Web of Science Core Collection was retrieved up to September 2022. CiteSpace was used for cooperation network analysis among countries, institutions and authors, co-citation analysis of literature, co-occurrence and cluster analysis of keywords. Drug development of biomarkers casually linked to IS was inquired by the PharmSnap Global New Drug Database. Results A total of 200 articles were retrieved, and these studies entered a stage of rapid development in 2018. England had 80 articles, with intermediary centrality of 0.37 and 27 cooperation countries, while the US had 63 articles, with intermediary centrality of 0.10 and 21 cooperation countries or territories. All of the above data were in the top three of all countries or territories, making England and the US research centers in this area. China has published 106 articles, only with 16 cooperation countries or territories. Rainer Malik from Germany had published 20 papers, with 552 citation and 25 co-authors, all ranking the first. IL-6 was the only biological factor defined as a cluster label in the keywords clustering graph, and “inflammation” was the second most studied risk factor for IS in the keywords co-occurrence graph in the last three years. Among the 12 biomarkers of IS identified by MR, coagulation factor Ⅺ and lipoprotein (a) were the more promising drug targets and relevant drugs have entered clinical trials phase. Conclusions MR studies in the field of IS were carried out mainly in European countries or territories represented by England, the US and China. Inflammatory factors such as IL-6 were major research hotspots, and related studies provided evidence for biomarkers, such as coagulation factor Ⅺ and lipoprotein (a), as drug targets.