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BACKGROUND: Bibliometrics and visual analyses based on thematic literature are particularly important for understanding the foundation and frontiers of postmenopausal osteoporosis research. OBJECTIVE: To perform bibliometric, citation, and visualization analyses of highly cited SCI papers in postmenopausal osteoporosis research over the last 20 years. METHODS: The top 100 highly cited papers on postmenopausal osteoporosis published between 2003 and 2022 included in SCI-EXPANDED catalog of the Web of Science database were obtained for bibliometric measure and visual analysis using CiteSpace software. RESULTS AND CONCLUSION: The top 100 highly cited papers have a total of 67 377 citations in the Web of Science Core Collection, with an annual average of 49.17 citations per paper. Postmenopausal osteoporosis research primarily involves medical, engineering, biological, and multidisciplinary fields. The subcategories are dominated by endocrinology and metabolism, and medicine: internal medicine. Stable and close cooperative network relationships have been formed globally. United States, University of California System, Cummings, and Steven R are the country, research institution, and author, respectively, with the most highly-cited publications. The frontiers of postmenopausal osteoporosis research mainly include calcium and vitamin D supplementation and fracture risk, clinical studies of bisphosphonates in the treatment of postmenopausal osteoporosis, atypical femur fracture, clinical studies of new drugs and sequential treatment of postmenopausal osteoporosis, predictors of fracture risk, mid- and long-term follow-up of osteoporotic vertebral compression fractures, genetic polymorphisms and hereditary factors, formulation and updating of clinical practice guidelines for postmenopausal osteoporosis. Large cohort studies, high-quality randomized controlled trials, systematic reviews, meta-analyses, and clinical practice guidelines are the great engines that drive the development of clinical research in postmenopausal osteoporosis. We should make efforts in the above areas to improve China’s international influence in the field of osteoporosis. [ABSTRACT FROM AUTHOR]

Objective To quantify the 100 most frequently cited papers in CPT for predicting research hotspots for benefitting future clinical outcomes. Methods Web of Science database was searched for publications related to CPT original research from January 1, 1900 to December 31,2022. And Cited Reference Search tool was employed for retrieving articles to determine the most cited item. Then a knowledge map was generated for number of citations, publication year, publication periodical, author unit, publication country and key words. Results Top 100 selected articles were cited from 11 to 196 times and publication period started from 1928 to 2016. Clinical research was the major type ( n = 93) and only 7 studies belonged to basic research. The largest contribution came from the United States ( n = 37),followed by Republic of Korea ( n = 9), Germany ( n = 6) and Italy ( n = 6) . The frequently appearing keywords were divided into 2 groups of "Neurofibroma" and "Clinical characteristic of pseudarthrosis". And term "NFl" was the latest hot spot in the most cited article. Conclusion Current researches on CPT focuse upon clinical treatment. Basic research on the pathogenesis of CPT is still relatively lacking. In the future, investment in basic research on CPT should be strengthened to provide a more comprehensive treatment for CPT. [ABSTRACT FROM AUTHOR]

This study used bibliometrics to analyze the characteristics of funded papers in the social sciences in Taiwan from 2015 to 2019, including the number of funded papers, funded paper ratio, document types, fields, type of publishing organizations, journal impact, and paper citation impact. The results indicate that the number of funded papers and the funded paper ratio of SSCI papers from Taiwan have both increased. In addition to articles and reviews, conference papers are a major type of funded paper for local SSCI papers. In terms of fields, the nontraditional social sciences, such as environmental sciences, psychiatry, and public/environmental & occupational health, have a particularly high funded paper ratio. However, the number of funded papers and funded paper ratio is the highest in the field of education & educational research. The fields of economics, management, and business have a large number of funded papers but a low funded paper ratio. Universities are the main funded institutions, but hospitals have the highest funded paper ratio. Funded papers tend to have higher paper citation impacts. Therefore, funding positively affects the productivity and impact of SSCI papers from Taiwan. [ABSTRACT FROM AUTHOR]

The proposal of a national strategy for the "New Western Land Sea Corridor" will affect the reconstruction of the overall freight distribution pattern in western China. As the most important hub node for cargo distribution and transshipment in inland areas, the inland port (or dry port) is of great significance to regional economic development, logistics systems, and the construction of a new regional development pattern. Therefore, 111 papers on inland port research in international core journals have been selected in this study to systematically review the research status of inland ports and put forward the key directions and development trends for future research to serve the theoretical research and construction planning practice of inland ports in China, and globally. In this study, the literature metrology method is adopted to divide inland port research and development into three stages: the first stage is the initial stage (before 2005); the second stage is the slow fluctuating growth stage (2006-2017); the third stage is the rapid increase stage (2018-present). Scholars are interested in inland port research mainly from mainland China, the Netherlands, Hong Kong, the United Kingdom, the United States, and other countries (regions). Related research topics on inland ports are mostly combined with transportation, logistics, and other fields, which indicates that inland ports have become an important part of transportation systems and supply chain transportation networks. Among specific related research topics, the concept of inland ports is an important research topic, mainly focusing on the differences in naming and function, facilities of inland ports under different geographical backgrounds, and additional functions extended with economic development; however, its concept has not yet been unified. Research on the spatial layout system of inland ports shows that the inland port site selection and layout can be roughly summed up as a supply chain-oriented pattern, and industrial cluster-oriented pattern; the former often near port cargo distribution of traffic nodes, while the latter is on the border between the end of the supply chain. The location and layout of inland ports are influenced by economic foundation, transportation infrastructure, and local policy factors. Inland ports have a profound impact on the region. In terms of spatial effects, they have an impact on urban spatial planning and land use; in terms of economic effects, they can promote regional economic development and employment; in terms of environmental effects, they can reduce energy consumption and emissions, and promote the realization of regional sustainable development. In the operation and control of inland ports, special attention should be paid to the relationship between port planning and each manager, as well as to the management system, to realize the efficient, sustainable, and healthy development of inland ports. Finally, based on the new trends of global inland port logistics research and the realistic demand of China, we put forward several suggestions for future research, including the redefinition of dry ports, spatial layout and planning of inland ports, their regional influence, the port-city relationship, risk of investment, and potential benefits of inland ports. [ABSTRACT FROM AUTHOR]

[Purpose/Significance] "The Belt and Road" is an initiative proposed by China in recent years to cooperate and develop a community with a shared future for mankind, which has been continuously highly concerned by all circles at home and abroad. From the perspective of the citation of highly cited papers, the academic exchange of countries along the Belt and Road initiative cam provide a quantitative reference for future international academic and technological exchanges, collaborative innovation and development. [Method/Process] Based on the highly cited papers among the countries along the "The Belt and Road" in the WoS database from 2013 to 2018, this paper constructed a reference matrix and analyzed the network structure, and drew a national citation network map for cluster division. Furthermore, it explored the current state of academic exchange along the "The Belt and Road" and the direction of Chinese academic output, and further analyzed the correlation between Chinese academic exchanges and trade cooperation with other 64 countries along the route. [Results/Conclusions] The research results show that the countries along "The Belt and Road" have close academic exchange and obvious "small world" characteristics. China is the core of academic exchange and the highly cited papers in many research directions in China are cited by many countries along "The Belt and Road". Besides, academic exchange and trade cooperation between China and countries along "The Belt and Road" are strongly related. [ABSTRACT FROM AUTHOR]

Objective　To understand the development status in the subject of pharmacy and provide recommendations for the construction of universities and the development of pharmacy by the bibliometric analysis of pharmaceutical papers from Double First-rate universities in China. Methods　China National Knowledge Network (CNKI), Wanfang and VIP databases were searched for Chinese literature, and Scopus database was searched for English literature. Duplicates and non-research literatures were deleted. 12 028 literatures were included. Excel 2016 software was used for statistical analysis. Results　From 2014 to 2019, the total number of papers published by Double First-rate universities increased year by year, with the highest increase rate of 14%. From 2014 to 2020, 11 178 papers were published in international journals, while only 850 were published in domestic journals. Nearly 93% of pharmaceutical papers flowed to foreign journals. Peking Union Medical College published the most papers in international journals. Sun Yat-sen University published the most SCI papers. Peking University published the most papers in domestic journals, while Fudan University published the highest number of papers in Q1 area. Only a few papers published with international coauthors from colleges or universities. The cooperation works were limited in the same province or municipality directly under the central government. Conclusion　Double First-rate universities should focus on strengthening international cooperation and inter-provincial cooperation, improving industry-university collaboration, and accelerating the transformation from scholar research to productions. [ABSTRACT FROM AUTHOR]

Objective: To analyze the bibliometric indicators of SCI papers in the field of pharmacy in China from 2010 to 2019 by Essential Science Indicators (ESI) and InCites databases, so as to know the status quo and development trend of pharmacy in China in the last decade. Methods: In search of papers from ESI and InCites databases, the publication time of papers for retrieval was set within the time span of 2010-2019, the research output location was "mainland China" and the research area was "pharmacology and pharmacy". Then，related SCI papers in the field of pharmacy contributed by researchers in mainland China from 2010 to 2019 were retrieved. Such vital data as publication years, specific journals, location of research institutions, international collaboration and funding for researches were analyzed statistically, and those papers with high influential impact were further retrieved and analyzed. Results: In the field of domestic pharmacy，a total of 81 679 SCI papers were published, including 13 720 international collaborative papers and 470 papers with high influential impact. The amount of SCI papers，the number of international collaborative papers and papers with high influential impact increased year by year. China had international collaboration with 129 countries or regions in the field of pharmacy，and 48 .49% of the papers were sponsored by domestic research funds. Conclusion: In recent 10 years, the scope of research in pharmacy at home has expanded gradually, academic influential impact has arisen steadily, and the number of international collaborative papers and papers with high influential impact has also increased quite noticeably. However, the quality of scientific papers as well as international collaboration demand further improvement. [ABSTRACT FROM AUTHOR]

In order to explore the hotspots and research trends of domestic research on biochar in tobacco agriculture in recent years, bibliometric methods were used to analyze papers about biochar application in tobacco planting research included in the China National Knowledge Infrastructure (CNKI). The numbers, annual distribution, author information, publications and research content were statistically analyzed, and the CiteSpace V visualization software was used to predict and analyze research hotspots. The results showed that a total of 114 journal papers and 81 dissertations on the application of biochar to tobacco planting were retrieved, including 8 doctoral dissertations and 73 master’ s dissertations. The institution with the most research in China was Henan Agricultural University, and Liu Guoshun was the scholar with the most published papers. Domestic research on tobacco biochar still lacked a stable core author group, and the number of core authors was small. Tobacco biochar application hotspots focused on tobacco quality, chemical composition and tobacco-growing soil. In recent years, research hotspots tended to be on the effects of biochar on soil microbial communities and heavy metals in tobacco leaves. [ABSTRACT FROM AUTHOR]

Traditional Chinese clothing patterns are an important part of excellent cultural heritage of China with unique visual effects and artistic charm providing abundant materials for modern design. They are widely used in the field of modern design and decoration and are an important symbol of the nationalization of Chinese design. Over the past 20 years scholars have conducted increasing research on traditional clothing patterns and explored the integration of traditional clothing patterns with modern design languages from different perspectives and different disciplinary backgrounds as well as the digital simulation and reconstruction of traditional clothing patterns. At present there is a lack of comprehensive quantitative analysis to objectively evaluate relevant research literature on traditional clothing pattern design transformation and there is an urgent need to grasp the theoretical trends in this field as a whole. This paper selected 425 journal articles on traditional clothing pattern design transformation research from CNKI in the past 20 years. Based on the CiteSpace software and content analysis method the research laws of traditional clothing pattern design transformation in China were sorted and analyzed from the dimensions of knowledge production context knowledge production subject knowledge foundation keyword co-occurrence and timeline. This paper adopted a dual perspective of bibliometrics and content analysis to clarify the research laws of traditional clothing pattern design transformation from the dimensions of time and space in order to provide reference for theoretical deepening application exploration and sustainable development in this field. Three major conclusions were drawn. First from the basic characteristics of the literature the number of publications on traditional clothing pattern design transformation has increased rapidly since 2001. Scholars have paid increasing attention to related research in the field of traditional clothing pattern design transformation. More scholars and research institutions have explored the traditional clothing pattern design transformation to varying degrees from different disciplinary backgrounds and accumulated a certain number of research results. However most of the scholars conduct independent research indicating a lack of collaborative research on the traditional clothing pattern design transformation. Therefore it is necessary to form more academic research teams and core research scholar groups. Second from the perspective of hot research topics the research on traditional clothing pattern design transformation has formed three research hotspots materialized expression of auspicious culture in traditional clothing pattern design transformation innovation of methods for extracting traditional clothing patterns and interdisciplinary integration driving the innovative development of traditional clothing pattern design transformation. Third from the perspective of research evolution the evolution of traditional clothing pattern design transformation can be roughly divided into three stages 2001 - 2008 2009 - 2016 and 2017 - 2022. The integration of multiple disciplines drives the continuous innovation of modern design and forms new development trends. For example the interactive design of traditional clothing patterns provides users with a better user experience traditional clothing pattern service design based on user emotional experience has become an emerging research direction the extraction and innovation of "Chinese elements" in traditional clothing patterns reflect cultural confidence in design transformation the traditional clothing pattern design transformation has gone through a change from commonality to individual psychological needs with design shifting from practicality to spirituality. [ABSTRACT FROM AUTHOR]

Objective A bibliometric analysis of the literature related to stroke and the blood-brain barrier was conducted to obtain a research map, explore hotspots and trends, and provide references for clinical treatment and research. Methods The literature related to stroke and blood-brain barrier from 1 January 2001 to 28 February 2023 was explored in the Web of Science core database. Using bibliometrics, CiteSpace V6.1.R6 was used to analyze the distribution of years, countries/regions, research institutions/system, authors, publications, cited literature, keywords and research trends. Results A total of 5028 papers were included after screening, with an overall upward trend in the number of published papers. The United States had the most research on this topic, followed by China’s mainland and Germany. Most of the top 10 research institutions/system were from the United States, France and China, with strong collaboration between countries/regions and research institutions/system. Among the authors, Chopp Michael from the United States ranked first with 49 papers. Among the research trends, ischemic stroke, miR-126 in non-coding RNA, blood-brain barrier dysfunction and drug delivery were the hot spots in the last three years. Conclusions Blood-brain barrier and stroke are inextricably linked. The dysfunction and repair mechanism of blood-brain barrier during stroke, the circulation biomarkers released by blood brain barrier and the use of blood-brain barrier opening time to increase drug absorption are worthy of further study [ABSTRACT FROM AUTHOR]

Objective The citation rate of a paper reflects the influence of this article in the field. The citation analysis of the 50 most cited literatures has been conducted in the field of orthopedics. However, to date, no report has been published on analyzing the highest cited literature in terms of bone cells mechanical stress stimulation. This study intended to analyze and study the characteristics of the 50 papers which have the highest citation rate on the research of bone cells induction by mechanical stress stimulation. Methods The databases of "Pubmed" and "Web of science " were searched with the search term of “Compressive stress OR Tensile stress OR Fluid shear stress OR stretch stress OR Centrifugal force OR Micropipette stimulation OR Electromagnetic force mode OR Mechanical stress OR Mechanotransduction” AND “Osteocyte OR osteoblast”” for the 50 articles with the highest cited frequency. Articles that were not relevant to the study were excluded. The title, first author, year of publication, journal, region of origin, authors' affiliation, number of citation, and other important information were recorded and analyzed. Results The number of citations ranged from 239 to 20. All of the 50 most cited articles were published between 1999 and 2015. The most productive year was 2009 (9). The top 50 articles were published in 27 journals, of which, Journal of Bone and Mineral Research (11) had the largest number of the included articles. The journal with the second largest number is Journal of Biological Chemistry (6), followed by Bone (5). The top cited articles originated in 12 countries, with America ranked the top (21). Seven institutions were responsible for more than one article. The most productive institutions were the University of Indiana (4) and Shanghai Jiao Tong University (3). Two authors were involved in more than one articles as the first author. The most studied signal pathway was MAPK-ERK signaling pathway (11), Wnt/beta-catenin signaling (9), PI3K/AKT signaling pathway (4) and BMP signaling pathway (2). Conclusion Identification of the highest cited papers not only helps to understand the research development on mechanical stress stimulation of bone cells and to guide future direction, but also can provide reference for researchers in reading literatures. [ABSTRACT FROM AUTHOR]

BACKGROUND: With the continuous improvement and progress of artificial intelligence technology in the treatment of spinal deformity, a large number of studies have been invested in this field, but the main research status, hot spots and development trends are still unclear. OBJECTIVE: To visually analyze the literature related to artificial intelligence in the field of spinal deformities by using bibliometrics, identify the research hotspots and shortcomings in this field, and provide references for future research. METHODS: The core database of Web of Science was used to search the articles related to artificial intelligence in the field of spinal deformities published from inception to 2023. The data were visually analyzed by Citespace 5.6.R5 and VOSviewer 1.6.19. RESULTS AND CONCLUSION: (1) A total of 165 papers were included, and the number of papers published in this field showed a fluctuating upward trend. The author with the largest number of articles is Lafage V, and the country with the largest number of articles is China. (2) Keyword analysis results show that adolescent scoliosis, deep learning, classification, precision and robot are the main keywords. (3) The in-depth analysis results of co-cited and highly cited articles show that artificial intelligence has three hotspots in the field of spinal deformities, including the use of U-shaped architecture (a mature mode of deep learning convolutional neural networks) to automatically measure imaging parameters (Cobb angle and accurate segmentation of paraspinal muscles), multiview correlation network architecture (i.e., spine curvature assessment framework), and robot-guided spinal surgery. (4) In the field of artificial intelligence treatment of spinal malformations, the mechanism research such as genomics is very weak. In the future, unsupervised hierarchical clustering and other machine learning techniques can be used to study the basic mechanism of susceptibility genes in the field of spinal deformities by genome-wide association analysis and other genomics research methods. [ABSTRACT FROM AUTHOR]

BACKGROUND: Ischemic stroke is a highly prevalent disease associated with apoptosis. Neuronal death occurs after cerebral ischemia, including necrosis and apoptosis. The ischemic core region is dominated by necrosis, while delayed neuronal death in the penumbra is dominated by apoptosis. The penumbra has become a target for the treatment of ischemic stroke. This bibliometric analysis was used to identify the characteristics, hotspots, and frontiers of global scientific output related to apoptosis in ischemic stroke over the past 5 years. OBJECTIVE: To analyze the role of apoptosis and its mechanisms in the pathological process of ischemic stroke through a bibliometric approach. METHODS: A total of 927 relevant literature records from 2018 to 2022 were retrieved from Science Citation Index Expanded (SCI-Expanded) and Social Science Citation Index Expanded (SSCI-Expanded) of the Web of Science Core Collection. Research trends and hotspots of apoptosis in ischemic stroke were visualized using Citespace, VOSviewer and Bibliometrix. RESULTS AND CONCLUSION: From 2018 to 2020, the number of papers on the role of apoptosis in ischemic stroke showed an upward trend, but in 2020, the number of papers began to reduce. China had the largest number of publications, and the United States ranked the second. Capital Medical University and BRAIN RESEARCH BULLETIN were the institutions and journals with the most articles, respectively. In recent years, the two keywords “expression” and “oxidative stress” have appeared more frequently. The bibliometric study showed that in the past 5 years, most of the studies focused on basic research, in which research on the role of apoptosis in ischemic stroke has gradually decreased in the last 3 years, showing a downward trend. On the contrary, nerve regeneration has gradually become a research hotspot, especially the regulation of neurotrophic factors under the influence of different mechanisms, and the research on angiogenesis and glial cell repair is on the rise. At the same time, apoptosis in nerve regeneration is a potential point of discovery. [ABSTRACT FROM AUTHOR]

[Objective]. The aims of this article are to intuitively grasp the progress and hotspots in the field of research of gully erosion in the northeast of China black soil region, advance the development of research in gully erosion in the black soil region of northeast China. [Methods] 245 papers in CNKI and Web of Science databases were used to create a knowledge map of gully erosion in the black soil region of northeast using the bibliometric method and CiteSpace software. [Results] (1) Research on gully erosion in black soil area started late, and the number of published papers has increased significantly in the past 10 years, but the results published in international journals are few, accounting for only 26%. (2) The research institutions in this field mainly distribute in northeastern China, of which several institutions include Songliao Basin Committee of Ministry of Water Resources, Beijing Normal University, Northeast Institute of Geography and Agroecology of Chinese Academy of Sciences, Northeast Agricultural University, and Shenyang Agricultural University have made the outstanding contributions and shown the great influence in the field; Prof. Zhang Shuwen is the scholar with the most publications in Chinese, and Prof. Liu Baoyuan and Wu Yongqiu are the scholars with the most publications in English in this field. (3) The co-occurrence of keywords between the published literatures indicates that the current focus of attention on gully erosion in the black soil area of northeast China is mainly on the development characteristics, influencing factors and prevention and control measures of gully erosion. [Conclusion] The comprehensive research framework and a full understanding on gully erosion in the black soil region of northeastern China have not yet been established. In future research, there is a need to further emphasize the study of the formation and development processes and mechanisms of gully erosion in the black soil region of Northeastern China, and to conduct in-depth analyses of the influences of geological, topographical, hydrological, and human activities, among other factors. [ABSTRACT FROM AUTHOR]

BACKGROUND: In recent years, the development of liver organoids has made it a hot spot in the field of international liver disease research, but there is still no article on the bibliometric analysis of liver organoids. OBJECTIVE: To explore the hot trends in liver organoids in the last 20 years based on bibliometrics and visualization analysis. METHODS: We searched the articles about liver organoids in the Web of Science Core Collection from January 1, 2002 to November 12, 2022. Origin, Office, and CiteSpace software were used for bibliometrics and visualization analysis. We statistically analyzed the number of annually published articles, countries, institutions, authors, journals, and keywords of the articles by generating charts. RESULTS AND CONCLUSION: The number of articles, citation frequency, institutions and personnel involved in the research about liver organoids showed an overall upward trend in the last 20 years, indicating that the field was growing rapidly and attention was increasing. The USA had published the most papers and had the strongest influence in this field. Although it had invested a lot of time and energy, the number of papers published by a single research institution in the USA was not the highest among many research institutions. China was second only to the USA in the number of publications, with the Chinese Academy of Sciences and Fudan University leading the list. Utrecht University in the Netherlands was the institution with the most publications. Clevers H was the author with the highest number of articles. The article with the highest co-citation frequency was “Long-term culture of genome-stable bipotent stem cells from adult human liver”. The main fields of study for liver organoids were Molecular Science, Biology, and Immunology. The most frequently occurring keywords were stem cell, in vitro, and culture. The research hotspots in the liver organoids field were mainly focused on in vitro stem cell three-dimensional culture, differentiation and gene expression. [ABSTRACT FROM AUTHOR]

Objective This study aims to elucidate the international frontier research trends and literature distribution related to prostatitis and pathogenic microorganisms through bibliometric and visualization analyses. Methods Data were collected from the Web of Science core collection database. We searched and collected research papers related to prostatitis and pathogenic microorganisms published in the past 25 years, and conducted analyses of citation, co-authorship, co-citation, bibliometric coupling, and co-occurrence. Results A total of 512 research papers were included, of which the total number of papers published and total citations in the United States far exceeded those in other countries. Nickel from Queen's University was the most cited author and organization. The most cited paper was published by Krieger. The keyword "Escherichia coli" has been a research focus in this field from 2015 to present. Conclusions Our results provide a comprehensive overview of the development process, current situation, research hotspots and possible future directions of the research on prostatitis and pathogenic microorganisms. it is expected to provide accurate and valuable reference for researchers in related fields to carry out follow-up research work. [ABSTRACT FROM AUTHOR]

BACKGROUND: Adolescent idiopathic scoliosis is the most common scoliosis deformity, accounting for about 80% of all scoliosis. Its pathogenesis is unknown. In recent years, the incidence rate has shown an obvious upward trend, which seriously threatens the physical and mental health of adolescents. OBJECTIVE: To perform the visualization analysis of the relevant literature on adolescent idiopathic scoliosis in recent 20 years through the Bibliometrics method, and explore the research hotspots and trends in this field to provide references for further research. METHODS: The relevant articles included in the Web of Science core collection database from January 1, 2002 to December 31, 2021 were searched by computer. The scientific knowledge map was drawn by CiteSpace 5.8.R3 software. The cooperation network, co-citation network, keyword co-occurrence, burst, clustering and timeline map were visually analyzed. RESULTS AND CONCLUSION: A total of 5 245 papers were included. In the past 20 years, the annual publication volume has shown a fluctuating upward trend. The analysis of the cooperation network shows that the author with the most publications is Qiu Yong; the institution is Nanjing University; the country is USA. The author with the highest intermediary centrality is Lowe TG; the institution is Childrens Hosp Philadelphia, and the country is Switzerland. The cocitation network analysis exhibits that the author with the highest frequency of citations is Lenke LG; the document is Weinstein SL, 2013, N Engl J Med; the journal is Spine, and the author with the highest intermediary centrality is Suk SI, and the cited document is Danielsson AJ, 2001, Eur Spine J; the cited journal is Spine. Keyword analysis displays that the research hotspots mainly focus on conservative treatment, imaging parameters, pathogenesis, and genome-wide associations. Through the visualization analysis of the literature in this research field, this study clarifies the context of the research in this field, reveals the research hotspots and trends in this field, and provides research ideas and methods for many scholars. [ABSTRACT FROM AUTHOR]

Objective To analyze the status quo, research hotspots, and frontiers of core muscle training (CMT) in domestic research on musculoskeletal pain using bibliometric methods. Methods Literature published from January 1,2014, to December 31,2023,on CMT for musculoskeletal pain was retrieved from databases including China National Knowledge Infrastructure (CNKI), Wanfang, and VIP database. Authors, research institutions, and keywords of the included literature were used as network nodes for co-occurrence analysis in CiteSpace6. 2 software, generating visualizations such as author and institution collaboration networks, and keyword distribution maps. Results A total of 312 papers were included, with the overall number of publications showing an increasing trend, albeit with a slight de- crease in the past two years. Most publications were from medical schools, and authors were mostly from small teams. Collaboration between institutions and authors needs to be strengthened, with low levels of inter-institutional and inter- regional cooperation. Research in this field was mainly focused on the rehabilitative efficacy of CMT for low back pain and lumbar spine function. Conclusion CMT has shown good efficacy in treating low back pain. Future research should focus on improving lumbar spine function, enhancing quality of life, and accelerating postoperative recovery through early application. [ABSTRACT FROM AUTHOR]

BACKGROUND: Exosomes have become one of the frontiers of biomedical research in recent years because of their promising applications in clinical diagnosis and therapy. OBJECTIVE: To reveal the basic research and technology development trend of exosomes at home and abroad, and provide suggestions for related scientific and technological research and development in China. METHODS: This paper presented a quantitative analysis of the overall research and development situation, the frontier hotspots and future development trends in this research area by means of bibliometric methods and tools. RESULTS AND CONCLUSION: The research and development hotspots in this area have entered a high growth phase with the application of new tools and methods. Many new technologies and products are facing clinical applications and markets with the development of a large number of clinical translation experiments. Comparative analysis at home and abroad reveals that China has made more remarkable achievements in basic research in this field, but there are still weaknesses in the possession of independent intellectual property rights, clinical technology translation, and regulatory system standardization and management, which need to be further strengthened in the future. [ABSTRACT FROM AUTHOR]

The study utilizes bibliometrics to explore papers and patents in the field of fuel cell to examine the scientific and technical development in the area. The research data were retrieved from the WOS database and USPTO patent data from the period between 1991 and 2010, which consists of 20,758 papers and 8,112 patents. The authors analyzed numbers of papers and patents to examine the trends in the papers and patents in different countries, organizations and individuals. The results indicate upward growth in both papers and patents in fuel cell, with a higher growth rate for papers. The study shows that major paper and patent output are concentrated in a small number of countries. An imbalance exists between the number of papers published and the patents granted in organizations. The organizations that published papers and patents vary in type and category. Very few individual researchers are able to produce high numbers of both papers and patents. [ABSTRACT FROM AUTHOR]

Objective Analyze the number and quality of the biomedical papers published by Chinese authors during 2000 to 2012. Methods The biomedical papers published by Chinese authors embodied in Medline were searched from 2000 to 2012，and the result was compared with that in SCI and F1000. Results 458，593 papers were searched，accounting for 5.06% of the total papers in Medline database in this period. Biochemistry and molecular biology was one of the fasted growing subject areas in the number of papers. 55.51% and 92.81% papers embodied in Medline were indexed by SCI in 2000 and 2012，respectively．Conclusion The results showed that the quality have improved obviously along with the rapid growth of number of biomedical papers published by Chinese authors. [ABSTRACT FROM AUTHOR]

Thanks to the cultural turn in human geography and the spatial turn in sociology, the space of "home, " is a multi-dimensional assemblage full of material, social and emotional elements. This paper utilizes CiteSpace and Bibliometric to analyze the papers on the geographies of "home" in the WoS core collection and CNKI Chinese core journal. By figuring out its cur‐ rent developments, including the number of papers, researchers and their institutions, published journals, research topics and important achievements, we summarize the overall characteristics and latest progress of Chinese and international researches on the geography of "home". It is found that this research has witnessed great development since the 21st century, while most focused on Western developed countries and regions. Besides, a number of research groups have been formed in many universities and research institutions. On the other hand, the geography of "home" in China is in its infancy for its insufficient researchers and outputs. In international academia, the journals of the geography of "home" have stronger academic influence, but the average citation frequency is low. In China, the journals are mainly hosted by the Institute of Geographic Sciences and Natural Resources Research, CAS. The average citation frequency of papers is significantly higher than the journal's impact factor. Research topics of the geographies of "home" are variable, such as mobility, transnational migration, gender and family. In recent years, there have been more research hotspots which have close relationships with the latest international current affairs. Chinese scholars tend to focus on mobility, the home of commerce and spatial practice and share many similar research interests with international researchers. However, discussions on "home" in the context of Chinese culture are still under-explored. [ABSTRACT FROM AUTHOR]

In order to keep up the research dynamics in the field of nitrogen monitoring in wheat, this paper explores the current status and content evolution through visual analysis. Using bibliometric methods, we mined the trend of publications, subject areas, countries, institutions, journals and highly cited papers, research hotspots, and theme evolution between 1990 and 2022, and analyzed the intersection of disciplines and the concentration of literature. The research found that the global publication volume is generally on the rise, and China is the fastest growing country in recent years, but it can be further improved in terms of the number of local citations and the total number of citations. The field of wheat nitrogen monitoring has changed from one single discipline to multidisciplinary, the hotspots have evolved from the analysis of a single physiological process to the monitoring of remote sensing, crop modeling, growth simulation, and other directions. The research hotspots have evolved from the early stage of single physiological process analysis to the direction of digital agriculture, forming two major research nodes in the world represented by China and the United States. Six of the top ten authors are from China, and China occupies six seats in the top ten organizations, and China ranks in the top in all four indicators of highly cited papers. As time goes on, the tendency of teamwork and international cooperation has become evident, and the proportion of collaborative publications between China and the top ten countries is 31.48%. Agronomy journals are the main publications, with Field Crops Research being the most representative. The results show that the cross-disciplinary trend has become more and more obvious, the development trend of research hotspots and fields has become clearer and clearer, and in the future, the in-depth cooperation among different countries, disciplines, and teams will bring greater and more far-reaching opportunities. [ABSTRACT FROM AUTHOR]

The use of language laboratory and relevant information technology in foreign language teaching is a necessary model and method in modern foreign language teaching. By using the full-text version of the Chinese Academic Journal Network Publication Database in CNKI, this thesis retrieves the statistic output of researches relating to laboratory use and makes a comparative study of the research distribution of time, periodicals, topics, authors and funding institutions. Then a Bibliometrics ' basic law is applied to investigate university language laboratory development process and its present situation, based on which the existing problems are identified. [ABSTRACT FROM AUTHOR]

BACKGROUND: Clinical use of vascular stents involves high medical costs, but it may also bring long-term benefits in reducing cardiovascular events and improving the quality of life in patients. Economics evaluation can help decision makers better understand the balance between the cost and benefit of treatment. OBJECTIVE: To analyze the related articles of health economics and discuss the hot spots in the study of the effect and problems of vascular stents in medical quality management. METHODS: The articles concerning health economics evaluation of vascular stents were retrieved from the core set of the Web of Science. The VOSviewer_1.6.19 software was used to make a visualization analysis of the annual publication volume, institutions, countries, keywords, etc. Finally, the research hot spots on the effects and problems of vascular stents were analyzed from the perspective of health economics and medical quality management. RESULTS AND CONCLUSION: (1) 120 articles in English were finally included. In the past 10 years, the highest number of articles published in this field was in 2019, with 10 articles. The institution with the largest number of articles published was Harvard University in the United States with 20 articles, and the country with the largest number of articles published was the United States with 58 articles. (2) Keyword cluster analysis demonstrated that the cost-effectiveness analysis of bare metal stents and drug-eluting stents in coronary disease, the cost-effectiveness analysis of angioplasty stent intervention, and the effect of coronary stents in percutaneous coronary intervention are the research hot spots in the field of health economics evaluation of vascular stent research. (3) In the context of medical quality management, the paper further summarized the research hot spots on the therapeutic effect of vascular stents as follows: long-term effect of vascular stents, safety, drug release mechanism research, personalized therapy, restenosis problems, and stent insertion technology. (4) The results of highly cited literature analysis exhibited that drug-eluting stents release drugs to reduce the risk of vascular restenosis, and the restenosis rate is lower than that of bare metal stents, but the cost is usually higher. Biodegradable stents combine the advantages of bare metal stents and drug-eluting stents, that is, avoiding long-term stent existence and reducing the risk of restenosis, but their cost may be higher, and there may be some complications in the short term, and they are not widely used at present. (5) In addition to the direct stent cost, factors that need to be considered when comparing the cost-effectiveness of vascular stents include the risk and cost of stent re-intervention, the risk and cost of complications, the duration and cost of drug therapy, and the quality of life of patients. Therefore, while the initial cost of drug-eluting and biodegradable stents may be higher than bare metal stents, they may lead to better clinical outcomes in the long term, resulting in a more favorable cost effect. (6) Future research directions should focus on making personalized vascular stent treatment decisions, observing the long-term effect of stent treatment, the impact of the stent on patients’ quality of life, formulating health policies, rational allocation of medical resources, and the establishment of long-term follow-up mechanisms. [ABSTRACT FROM AUTHOR]

Objective To analyze the current research status, hotspots, and frontier fields of perivascular spaces from 2013 to 2023 based on bibliometric analysis. Methods The related English article of perivascular spaces was retrieved in the Web of Science Core Collection from January 1, 2013 to June 19, 2023. CiteSpace V6.3.R1 software was used to analyze the cooperation network among the publishing countries, institutions and authors; the co-citation network of reference, first author of reference and journals; the co-occurrence network of keywords, burst analysis of keywords and reference co-citation. VOSviewer 1.6.15 software was used for keywords cluster analysis. Results A total of 1549 papers were included. The annual publications from 2013 to 2023 showed an overall increasing trend. The United States ranked the first and China ranked the second. The top three prolific institutions were Harvard University, Massachusetts General Hospital and University of Edinburgh. Cooperative network analysis showed that the cooperation between countries was close and domestic institutions collaborated less with other institutions. Wardlaw Joanna M from University of Edinburgh ranked the first in publications. The top ten keywords in co-occurrence network were small vessel disease, enlarged perivascular spaces, MRI, brain, Virchow-Robin spaces, Alzheimer’s disease, dementia, risk, stroke and glymphatic system. Cluster analysis of keywords showed that cerebral small vessel disease, dementia and MRI were current hotspots, and glymphatic system was a new research direction. Burst analysis of keywords suggested diffusion imaging has got much attention since 2021. Conclusions The research on perivascular spaces has increased during the recent 10 years. Cerebral small vessel disease was the main hotspot and glymphatic system was a new direction. Diffusion tensor imaging was a frontier field. [ABSTRACT FROM AUTHOR]

Objective To summarize the research progress and hotspots of traditional Chinese medicine (TCM) in the treatment of pulmonary fibrosis (PF) and provide references for future research. Methods Literature regarding TCM treatment for PF retrieved in the CNKI database from January 1, 1995 to January 1, 2023 was selected. The VOS viewer was utilized to conduct visualized analysis, and current and future potential hotspots and directions were proposed. Results A total of 794 related papers were included. The number of articles on TCM for treating PF showed an upward trend annually, peaking in 2020. Beijing University of Chinese Medicine published the most papers in this field. The top 10 keywords were idiopathic pulmonary fibrosis (375 times), pulmonary fibrosis (314 times), TCM (262 times), clinical research (58 times), pathogenesis (55 times), bleomycin (40 times), TGF-β (28 times), atrophic lung disease (31 times), epithelialmesenchymal transition (26 times), and Buyang Huanwu Decoction (26 times). In the past 3 years, the treatment direction has shifted from TCM formula to single herbs. The research focus of traditional Chinese medicine in the treatment of pulmonary fiber is in the fields of etiology, pathogenesis, and clinical research. Conclusions Recognition of TCM in treating PF is gradually increasing. Related research has transformed to focus more on single Chinese herbs. [ABSTRACT FROM AUTHOR]

Achieving carbon neutrality is an important response to climate problems, and existing studies lack a summary analysis of its hot spots and evolution. Based on Bibliometric methods, this paper analyzed the "carbon neutrality" and related topics in the core collection of Chinese database CNKI (3 674 articles) and foreign database WoS (9 733 articles). The findings are as follows: (1) Highly cited CNKI literature has less research on technical methods than WoS literature; (2) Authors of Chinese and foreign literature cooperate more within the team and less among the teams; (3) Institutions with closer geographic locations cooperate more. Most publishing agencies come from China with the largest number of publications, but their influence is less than that of developed countries such as the United States; (4) Carbon emission is a hot issue in both types of literature. CNKI literature focuses on the decomposition and accounting of carbon emission factors, WoS literature focuses on the assessment of emission reduction effect and technical research methods. Finally, the paper looks ahead to energy efficiency and energy transformation, carbon trading and carbon tax, implicit carbon emissions and other issues. [ABSTRACT FROM AUTHOR]

In order to analyze the research status and hot trends of water resources ecological footprint, this paper takes CNKI and web of science database as data sources, and uses CiteSpace visual analysis software to comprehensively analyze development status and research hotspots of Chinese and English papers in the field of water resources ecological footprint from 2005 to 2020. The former includes the number of publications, sources of literatures, research institutions, authors, regional cooperation networks and highly cited literatures, while the latter includes keyword cluster analysis and hot emergent word analysis. The development status results show that on the study of ecological footprint of water resources, the Chinese literatures are earlier than the English literatures, and the number of published papers of both show an increasing trend, which are the hot research fields at present. The Chinese and English literatures mainly come from the core journals in the field, mainly involving the environment and ecology and other fields. The cooperative network of Chinese literatures research institutions are relatively decentralized, while the cooperative relationship of English literatures research institutions are closer. There are more researchers in Chinese literatures, forming a relatively obvious cooperative subgroup, while there are fewer English literatures writers and most of them are Chinese scholars. Countries such as China, the United States and the Netherlands are the main forces of literature publication. In the analysis of hotspot emergent words, the intensity of ecological footprint is the highest, indicating that the research of water resources ecological footprint has entered a mature stage. In the future, the depth and breadth of research in the field of water resources ecological footprint should be strengthened to achieve interdisciplinary integration. [ABSTRACT FROM AUTHOR]

Objective To understand the research hotspots and research trends about convolutional neural networks in the field of oncology imaging diagnosis by analyzing the characteristics of published literature at home and abroad over the past decade. Methods The SCI-E database was used as the data source to retrieve literature about convolutional neural networks in the field of oncology imaging diagnosis published from 2012 to 2022. The distribution characteristics of countries, institutions, journals, co-cited authors, and keywords of the studies were analyzed by CiteSpace software. Results A total of 1088 papers were eventually included, and they were mostly from China, the United States, and India. A total of 39 papers were published by Sun Yat-sen University, the research institution with the highest number of publications. Radiology Nuclear Medicine Medical Imaging was the journal with the highest number of publications. A total of 25 high-frequency keywords and 15 burst keywords were obtained. The formation of 12 author co-citation clusters such as image segmentation and lung nodule, as well as 11 keyword clusters such as automatic segmentation and breast cancer, was observed. Conclusion Current research on convolutional neural networks for oncology imaging diagnosis focuses on oncology segmentation, lung-nodule recognition, assisted diagnosis of breast cancer, and other high-frequency oncology. [ABSTRACT FROM AUTHOR]

In order to clarify the development process of landscape architecture research and look forward to the potential development direction of landscape architecture in China, using bibliometrics and CiteSpace information visualization software, 7 164 research literatures on landscape architecture in CNKI database from 2011 to 2020 were analyzed to determine the current situation and the trend of landscape architecture research during this period. The results showed that the quantity of annual published papers increased first and then decreased, reaching the maximum in 2019 and then decreasing. The discipline fields mainly were focused on engineering, horticulture and economics, and the publications were mainly distributed in engineering technology and basic and applied basic research, which was less in line with humanities and social sciences. Meanwhile, the national and local financial support for related research was low. Planning and design, teaching reform and construction had been the research hotspots of landscape architecture development in the past ten years, but there were differences in the research hotspots in different periods, and the research fields showed the characteristics of diversification. The development of landscape architecture was divided into two stages, which were the research stage of basic research on plant landscape, planning and design, construction and teaching mode and teaching method from 2011 to 2015, and the research stage of conservation technology, energy-saving technology, natural protected area and landscape regeneration from 2016 to 2020 were mainly focused on ecological concept and low-carbon concept. [ABSTRACT FROM AUTHOR]

The material flow analysis (MFA) method is widely used in the fields of resource management, environmental governance, and sustainable development evaluation, but the progress of its international research and the paths to support carbon neutrality are still unclear. Therefore, following the logic of ' sorting-integration - expansion,' this study first analyzed 2 148 documents included in the core database of Web of Science from 2000 to 2022 by using CiteSpace bibliometric tools, captured the key knowledge base and topic evolution of the international MFA research, and conducted a detailed review and comprehensive analysis of the MFA frontier application research. Second, by integrating the current status of international MFA research and the paths to carbon neutrality, this study constructed an integrated MFA research framework towards carbon neutrality. Finally, this paper summarized the support paths of MFA application research for the four important carbon reduction sectors and proposed current research deficiencies and future development directions. The main findings include: (J) The key studies in the fields of ' resource management,' ' environmental accounting,' and ' indicators ' could serve as a methodological and theoretical basis for MFA to perform its management, accounting, and evaluation functions. © With the support of the basic research topics of 'industrial ecology,' 'material flow analysis,' and 'material flow management, ' the application research topics of MFA had gradually evolved from the outdated topics of ' nitrogen,' ' Tarragona province,' ' heavy metals,' and ' alloying elements' to the frontier topics of ' municipal solid wastes,' ' iron,' ' circular economy,' ' exposure,' and ' renewable energy,' and the integrated application of MFA with the methodologies of scenario analysis, life-cycle assessment, and input-output modeling had become a mainstream trend. © The integrated MFA research framework towards carbon neutrality consisted of three modules, i.e., theoretical and methodological basis, application research paradigm, and supporting pathway for carbon neutrality, of which the structure of the application research paradigm reflected the core functions of the MFA, i.e., accounting material stocks and flows, assessing material demand and recycling potential, and developing the material management system. The elements of the application research paradigm covered the metabolic object, spatial scale, application triggers, main content, and application purpose of MFA research. ® The studies of MFA application supported the four important carbon reduction sectors in heterogeneous ways, and their relevance to the goal of achieving carbon neutrality needed to be further improved. In future research, MFA can be applied to account for the resource demand and waste generation of specific zero-carbon technologies in the energy production sector, to assess the resource and environmental impacts of end-use electrification, efficiency, and cleaner technologies in the energy consumption sector, to measure the environmental exposures and economic feasibility of the technologies for decarbonization and solid-waste utilization in the industrial and commercial sectors, and to evaluate the metabolic efficiency of nutrients and the performance of biological carbon fixation in the agriculture and forestry sectors. [ABSTRACT FROM AUTHOR]

Objective To employ OSviewer and CiteSpace to explore the development trends and research hotspots of allergic rhinitis (AR) in the field of immunotherapy. Methods Web of Science (WOS) core collection was searched and the literature related to immunotherapy and AR retrieved. VOSivewer and CiteSpace were utilized for visually analyzing the country, institution, author, keywords and citations of the literature. Results Among a total of 2 846 articles, the largest number of publications was the United States (567), institution with the largest number of publications University of Genoa (102) and centrality of University of Genoa 0.12. It attained betweenness centrality; Top 3 authors by number of publications were Stephen R Durham (63 articles), Giovanni Passalacqua (46 articles) and Oliver Pfaar (44 articles); Top 3 journals by number of publications were Allergy (222 articles), Journal of Allergy and Clinical Immunology (189 articles) and Clinical and Experimental Allergy (141 articles); Top 3 keywords were AR (770 times), asthma (362 times) and sublingual immunotherapy (359 times). It hinted at an important association between AR and asthma. From the perspective of overlay visualization. The hotspots were intralymphatic immunotherapy, subcutaneous immunotherapy and immunotherapy. The research frontier was intralymphatic immunotherapy. Conclusions Research popularity of immunotherapy for AR shall continue. The United States has published the most papers in this field and occupies a leading position. As for institutions, University of Genoa has betweenness centrality to play such a pivotal role that it is a potential institution to cooperate with. Research frontier of "intra-lymphatic immunotherapy" should be further explore for promoting the research advances of immunotherapy for AR. It can also provide solid theoretical rationales for offering a new and effective treatment of AR. [ABSTRACT FROM AUTHOR]

Objective To discuss the research situation, hot spots and future trends in diabetes nursing nationally and internationally over the last decade based on bibliometrics. Methods Research papers on diabetes care, included in China National Knowledge Infrastructure (CNKI) and Web of Science (WOS), were retrieved from 2013 to 2022. CiteSpace 6.1.R6 was used to analyze the distribution of publishing institutions, high-frequency keywords, keyword clustering, keyword time zone graph and emergent words. VOSviewer was used to analyze the network of authors. Results A total of 2 979 articles were included. Of these, 2 155 were in English and 824 were in Chinese. The annual publication volume of diabetes care was stable both nationally and internationally, and the number of publications in the top 10 journals accounted for 29.71% (885/2 979) of the total. There were a number of high-yield authors (more than 10 articles) who continued to devote themselves to diabetes care research at home and abroad. The most frequent keywords at home and abroad were "diabetic foot", "health education", "self-management" or "management", "glycemic control", "self-management". In the last 3 years (from 2020 to 2022), the keywords with the longest emergence time and the highest emergence intensity were "validity (3.54)" and "reliability (2.64)" of CNKI and "weight (3.52)" and "clinical trial (3.36)" of WOS. Conclusions Diabetes nursing research is progressing at a steady rate. Over the past decade, research has focused on topics related to diabetes self-management, glycemic control, quality of life, and diabetic foot. Among these, diabetes-related scales, weight management, and clinical trials have received considerable attention in the last three years. [ABSTRACT FROM AUTHOR]

In order to understand the influence of flocculation on sludge dewatering performance in recent ten years ・ Taking SCI periodicals collected by the Web of Science from 2011 to 2022 as data sources, using the visual analysis tool CiteSpace to draw a map for analysis・ The results showed that the number of articles published and cited in this field had increased year by year in recent ten years, and China was in the leading position. China Academy of Sciences, Tongji University were among the top publishing organizations ・ The research in this field was mainly published in high-level journals such as Bioresource Technology and Water Research ・ The research focused on the influence of flocculation on the dewatering performance of activated sludge,让s mechanism and practical application・ The combined treatment technology with multiple sludge dewatering methods will be a hot research direction in the future・ This paper summarized the research status and hot topics of flocculation to improve sludge dewatering performance, and provided ideas for future research. [ABSTRACT FROM AUTHOR]

Objective The aim is to comprehensively understand the research status and application trends of oily drilling sludge at home and abroad. Methods Based on China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) databases, this paper searched literature relating to oily drilling sludge research from 2007 to 2021, and adopted bibliometric method in analysis from multiple perspectives. Results The number of papers published in Chinese and English was rising from 2007 to 2021 while the former was higher than the latter. The funded projects with the largest number of publications globally were the National Natural Science Foundation of China. The influential institutions at home and abroad were China University of Petroleum (East China) and King Fahd University of Petroleum and Mineral Resources in Saudi Arabia. Researchers from China were highly active in this field, while the United States still takes the international leading position. Domestic research focused on drilling technology and petroleum sludge treatment, while studies aboard paid more attention to drilling materials and polluted water treatment. We also concluded that the studies on resource utilization of drilling mud was inadequate. Conclusions The resource utilization of oily sludge has become a research hotspot currently. Further, the harmless treatment and resource utilization of oily sludge for greening planting soil could be regarded as an important research and development direction. [ABSTRACT FROM AUTHOR]

Objective To explore the research status, hotspots, and trends in the field of stroke genetics and genomics according to bibliometric analysis on published literature since publication of the working draft of human genome. Methods The last two period (from 2000 to the present) was divided into 3 stages based on representative genomic technologies, namely first-generation sequencing (2000—2007), wholegenome genotyping microarray (2008—2015), and next-generation sequencing (2016—now). All of the published literature (written in English) on cerebrovascular disease genetics and genomics were retrieved from core collection of Web of Science. Year of publication, country/area, and institution of the literature were summarized. VOSviewer 1.6.18 was used for statistical and visual analysis. The H-index was used to evaluate the quantity and the impact of the literature. Results A total of 8833 English literature was included in this analysis. The United States was the main contributor to the literature on stroke genetics and genomics, and published 3291 articles with an H-index of 182, both ranking first in the quantity and H index of papers. China published 1765 papers with an H-index of 66, ranking second in the quantity and tenth in H-index. The International Stroke Genetics Consortium (ISGC) was an important contributor in this field of stroke genetics and genomics. ISGC and its principal directors ranked among the top 20 authors in the number of publications. The hotspots gradually shifted from association analysis and metaanalysis in the early stage to Mendelian randomization in recent years. Conclusions In the field of stroke genetics and genomics, although our country started late, there is a trend of catching up in the total number of publications. Clinical and scientific researchers in China should strengthen domestic and international academic cooperation to further enhance the China’s influence in this field. [ABSTRACT FROM AUTHOR]

BACKGROUND: Gastric cancer stem cells are a hot research topic in the medical field in recent years. Gastric cancer stem cells can interfere with the occurrence, metastasis, recurrence and drug resistance of gastric cancer. In theory, gastric cancer stem cells are the most promising candidate targets for the treatment of gastric cancer in the future. Therefore, studying the action mechanism of gastric cancer stem cells can not only elucidate the occurrence and development of gastric cancer, but also help to find new effective molecular targets, and has broad application prospects. OBJECTIVE: To summarize the hot spots and development trends of gastric cancer stem cells and to provide a reference for scientific researchers in related fields based on bibliometric and visualized analysis. METHODS: CiteSpace was employed to conduct the visualized analysis of annual publications, authors, countries, journals, citations and keywords of the related papers from 2011 to 2021 in the Web of Science Core Collection. RESULTS AND CONCLUSION: A total of 2 832 papers were included for analysis after screening. The annual publications increased rapidly, and the United States and China were the top contributors. Although the total number of papers published by Chinese researchers ranked the first in the world, the papers had low centrality and citation frequency, which indicated low quality and weak academic influence. Oncotarget was the journal with the largest number of articles published, and Oncology Letters was the journal with the largest number of articles published by Chinese researchers. Gastric cancer stem cells presented the trend of interdisciplinary development. The current studies about gastric cancer stem cells mainly focused on epithelial-mesenchymal transition; effect on biological function of gastric cancer cells and self-renewal. The plasticity of gastric cancer stem cells, the relationship with fatty acid oxidation and vascular endothelial growth factor, and the regulation of non-coding RNA on gastric cancer stem cells may be the focus of current and future research. The research of gastric cancer stem cells is currently in a rapid rise stage. In recent years, the action mechanism of gastric cancer stem cells is gradually clear. The treatment of gastric cancer stem cells will be a new targeted therapy strategy for gastric cancer patients in the future. [ABSTRACT FROM AUTHOR]

As the important symbol of sci-tech revolution and industrial transformation, intelligent robot has become the important power in driving economic and social development. In order to comprehensively analyze the research status, research trends and the evolution process of research hotspots in the field of intelligent robots in China, this paper took 2258 related papers collected in the database of CNKI in recent 20 years as the data source. Statistical analysis was conducted including the distribution of annual publications, distribution of periodicals, and distribution of research institutions. Meanwhile, the co-ocurrence analysis on keywords and research institutions and keywords emergence as well as time line on key words were carried out based on CiteSpace. As shown by the results, the quantity of annual publications rises stably and the past 5 years witness rapid growth. The cooperation cluster of research institutions features cross-domain cooperation and collaborative research between universities and enterprises. Cluster labels of key words are classified into 10 types. Research hotspots can be divided into two major categories of intelligent robot application and core technologies, including intelligent robot, industrial robot, service robot, artificial intelligence, sensor, machine vision, path planning, intelligent control and human-computer interaction. [ABSTRACT FROM AUTHOR]

As an ideal 'indicator' for directly monitoring plant photosynthesis, solar-induced chlorophyll fluorescence(SIF) has a rapid response to variations in plant physiological status. SIF is becoming one of the most active research direction in vegetation remote sensing. This study conducted a systematic literature review on topics of relevance to SIF. To do so, there are 786 SIF-related papers published during 1982-2021 were collected from the Scopus database. Based on VOSviewer, the visual bibliometric analysis was applied to analyze these papers from the perspective of country, institution, author, journal and keyword. The results show that the number of SIF articles published per year is rising rapidly. Among all the countries, United States, China and Germany published 285, 263, and 166, making them the top three countries that have the most SIF papers during the study period. Germany has the highest citations per publication (56.2) and the largest number of cooperative countries(36). Nanjing University, California Institute of Technology, and University of Valencia have made outstanding contributions to the development of this field as they have not only the large number of publications but also the high h-indices Among the scholars in this area, Guanter L(Polytechnic University of Valencia), Zhang Y(Nanjing University), Frankenberg C(California Institute of Technology), Liu L(Institute of Remote Sensing and Digital Earth, Chinese Academy of Sciences), and Rascher U(Jülich Research Centre), are currently the most productive, having published more than 40 papers. The Journal Remote Sensing of Environment has the highest number of SIF articles (92) and the highest H-index (40), and Global Change Biology has the highest citations per publication (65.6) in this field. The keyword analysis shows that SIF is a highly multidisciplinary area mainly involving geoscience, ecology, agronomy, plant physiology across a range of spatial and temporal scales. Currently, the most active research topics are the monitor of plant physiological status and stress condition, the acquisition methods of SIF measurements, and the applications of SIF in remote sensing such as terrestrial carbon cycle. China leads the world of overall research focus in this field, which, however, still should have a further improvement of its influence. [ABSTRACT FROM AUTHOR]

Objective Based on bibliometrics, CiteSpace software was used to analyze the current research status and hot issues in the field of caregivers of stroke patients at home and abroad, to provide reference for further research in this field. Methods The relevant literature in the field of caregivers of stroke patients was retrieved from the China National Knowledge Network (CNKI) and Web of Science database from the database inception to December 31, 2021. The types of articles included clinical trials, reviews, dissertations and conference papers. Bibliometric analysis was conducted in terms of the number of papers, authors, institutions, countries and keywords. Results A total of 1298 Chinese and 1763 English literature were included. The number of these published articles is on the rise year by year both at home and abroad. In the database of CNKI, the number of published articles increased from 4 in 2002 to 164 in 2021. Zhang Zhenxiang of Zhengzhou University published the most (48 articles), and the Nursing and Health College of Zhengzhou University published the most (50 articles). In addition to the subject words, "influencing factors" "caring ability" "caring burden" "depression" "anxiety" and "self-perceived burden" were high-frequency keywords. In the Web of Science database, the number of published articles increased from 103 in 2009 to 201 in 2021, and the United States published the most (565 articles); Dr. ROTH D L of Johns Hopkins School of Medicine published the most; the Univ Toronto had the most publications (55 articles). "Quality of life" "rehabilitation" "support" "burden" "care" "depression symptom" and "survivor" were high-frequency keywords. Conclusion The research on caregivers of stroke patients at home and abroad was in a stable development stage in the recent ten years. The authors and institutions of these papers were all characterized by universities and regions, and lack of cross-regional and cross-unit cooperation. Domestic and foreign research hotspots were different. The influencing factors of caring burden and caring ability, and negative emotion of stroke caregivers were hot issues in China. The influencing factors of stroke caregivers' quality of life, caring burden and depressive symptoms of caregivers, and the influence of rehabilitation led by caregivers on stroke patients were hot issues abroad. The clinical and research workers should strengthen the cooperation among research institutions, pay attention to the research frontiers and hotspots, to improve the depth and breadth of research. [ABSTRACT FROM AUTHOR]

Objective: To explore the development status, research hotspots and research frontiers of immune escape by bibliometrics, so as to provide guidance for researchers and clinical workers. Methods: Web of Science Core Collection （WoSCC） literature related to immune escape from 2002 to 2021 was searched, using Microsoft Excel 2020, Software such as CiteSpace V and VOSviewer visually to analyze the information extracted from the included literature and generate network maps. Results: A total of 634 articles related to immune escape were collected in WoSCC from 2002 to 2021, and the number of articles showed an increasing trend year by year. The largest published country and institution is China （214, 33.75%） and Harvard University （39, 6.15%）. The researcher who contributed the most to this field was KENT from Australia （10, 2.76%）. J Immunol published the largest number of papers in this field（ 24, 3.78%）. Cancer, immunotherapy and infection are the research hotspots of immune escape in recent years. Immunotherapy, cell, gene and antigen are the current research frontiers in this field. Conclusion: Research on immune escape is currently booming, and China has made remarkable contributions to this field. The current research hotspot in this field mainly focuses on the immunotherapy for cancer and infectious diseases, and the topics such as cell, immunotherapy, gene and antigen are the current research frontier, and will also be the future development trend in this field. [ABSTRACT FROM AUTHOR]

Objective Analyze the current situation, hotspots and development trends of sarcopenia animal model to provide research direction and basic information for sarcopenia animal model research. Methods English literature of research on animal models of sarcopenia was retrieved from the Web of Science core data (WOS) set from 1900-01-01 to 2022-12-31. Chinese literature related to animal models of sarcopenia was retrieved from CNKI database between 1915 and 2022. The bibliometric analysis software VOSviewer was used to explore the countries, orgonizations, authors, hotspots and frontier directions in these studies. Results A total of 2 819 articles on animal models of sarcopenia were retrieved from WOS core database. The first paper was published in 1995. The United States has the largest number of animal model studies of sarcopenia with 1 105 articles. The institution with the most published articles is the University of Florida in the United States, with 69 articles. The University of Hong Kong has the highest number of publications in China, with 20 articles. American author Van Remmen H, with 50 publications, is the author of the most articles. The journal with the largest number of articles published on animal models of sarcopenia is the American journal called FASEB Journal, with 196 articles. In total, 423 articles on animal models of sarcopenia were retrieved from the CNKI database. Author LI Zhuyi has published 19 articles, and is the author of the most articles in China. The keyword co-occurrence clustering analysis of WOS literature search found that the research focus on animal model of sarcopenia can be summarized as the correlation between sarcopenia and metabolism, cytology and regenerative medicine of sarcopenia animal models, the study of sarcopenia animal models in bone, muscle, nerve and exercise therapy. The retrieval results of CNKI database revealed that the most extensive research was about on the model of denervated sarcopenia, and researches on the effects of Chinese medicine on sarcopenia were also widely reported. Through reading the full articles or abstracts of the literature, the animal models of sacopenia mainly include natural aging model, genetic modification model, high-fat diet induction model, disuse model, hormone induction model and complex sarcopenia models of other diseases. Conclusion In recent years, the study on animal model of sarcopenia has become a hotspot at home and abroad. The bibliometric analysis provides a basis for the research of animal models of sarcopenia in terms of research direction, hotspots, model animal selection, animal model making, and domestic and international communication and cooperation. [ABSTRACT FROM AUTHOR]

The concept of green agricultural development is an important basis for guiding agricultural transformation and upgrades with advances in China. Since its proposal, this concept has received extensive attention from researchers and the number of papers published on it has increased rapidly. We examined research papers related to green agricultural development published since 2016 and used a bibliometric method to comprehensively and systematically analyze research hotspots in green agricultural development. The hot topics for research in this field include：theory, policy mechanisms, evaluation, controlling agricultural non-point pollution sources, and the experience of developed countries. We propose future research directions based on an in-depth analysis of various hot research topics. These results provide a scientific reference for further studies of green agricultural development in China. [ABSTRACT FROM AUTHOR]

To analyze the characteristics of cited papers in Chinese Mental Health Journal, so as to provide evidence for mining high-quality manuscripts. Methods: All of the papers published in Chinese Mental Health Journal from the date of its inception to December 31th, 2019 were selected as the research ob jects. Publication time, subject, and institution and fund paper indicators of the cited papers were analyzed, focusing on the distribution of the top 20 cited papers. Results: All of the 6689 papers were published in Chinese Mental Health Journal from its inception to the end of 2019, of which 5892 were cited at least once, 1202 were highly cited (determined as cited frequency 32 according to Price ' s law), and the total number of cited papers was 153 598. In the annual citation distribution, the number of citations and times of papers published from 2000 to 2005 were the highest. In the discipline distribution, the most times cited were psychology, basic medicine and psychia try. In the institutional distribution, the citations of papers published by Peking University, Central South University and Beijing Normal University were top three. In the distribution of fund support, National Natural Science Founda tion of China, National Science and Technology Support Program and Natural Climbing Program were top three. Although the number of papers supported by interdisciplinary and outstanding research backbone projects was small, the number of citations was high. Conclusion: psychology, psychiatry and basic medicine are 1he key disci plines cited, and 1he quality of national longitudinal project funded papers is higher, so we should actively tap the high-quality manuscript sources in interdisciplinary and excellent scientific research backbone projects. [ABSTRACT FROM AUTHOR]

based on the Chinese Social Sciences Citation Index database, based on a sample of 1,179 papers on Tujia people in CSSCI from 2000 to 2021, this paper analyzes and summarizes the current situation and achievements of Tujia people research in the past 20 years in China. Over the past 20 years, experts and scholars have conducted extensive and in-depth re⁃ search on Tujia people from different perspectives, such as politics, economy, culture, religion, art, nationality and population, and published many high-quality academic papers. In order to understand more accurately and scientifically the current situa⁃ tion and development trend of domestic Tujia people studies since the 21st century, we carefully analyzed the main contents, subject words, basic viewpoints and research value of Tujia research papers in CSSCI database, and put forward the prospect of research prospect in Tujia people. [ABSTRACT FROM AUTHOR]

BACKGROUND: Femoroacetabular impingement syndrome is one of the main causes of hip pain, and there is a lack of research in the field of rehabilitation for femoroacetabular impingement syndrome in China. OBJECTIVE: To present the research trends and research hotspots in the field of femoroacetabular impingement syndrome rehabilitation based on the Web of Science and Citespace software in the form of scientific data combined with atlas and to analyze research prospects and propose future research directions. METHODS: Keywords regarding femoroacetabular impingement syndrome rehabilitation from 2012 to 2021 were searched in the Web of Science Core Collection, and the results were bibliometrically analyzed. Citespace software was then used to conduct visually analyze countries, institutions, authors, journals, keywords and co-cited references. Finally, research trends and hotspots in the past 10 years were summarized. RESULTS AND CONCLUSION: Femoroacetabular impingement syndrome rehabilitation has gradually attracted the attention of scholars and the number of publications and citations has increased yearly, with the United States taking the lead. Chinese scholars have published fewer papers in this field and only have cooperative relations with Australian and American scholars. China’s influence in this field needs to be improved. Keyword and literature co-citation burst analyses indicate that the research trends are gait function in patients with femoroacetabular impingement syndrome, clinical efficacy of non-surgical treatment/conservative treatment/physiotherapy for femoroacetabular impingement syndrome, and the efficacy of hip arthroscopy vs. non-surgical treatment. The high-frequency co-citations, high centrality and cluster analyses indicate that the research hotspots in this field are exploring the diagnosis of pain due to femoroacetabular impingement syndrome, the short-, medium-, and long-term clinical effects of non-surgical treatment vs. hip arthroscopy, the rehabilitation effect of physiotherapy, the applicability of self-report scales, the rehabilitation scheme of femoroacetabular impingement syndrome with cartilage injury or glenoid lip injury and paying attention to their rehabilitation process, preventing femoroacetabular impingement syndrome from progressing to osteoarthritis. Based on the analysis of relevant literature in the past 10 years, this review details the future research directions in this field, including explorations on the clinical efficacy of non-surgical/surgical treatment, the middle- and long-term efficacy of non-surgical treatment vs. surgical treatment, the concurrent loss of femoroacetabular impingement syndrome, and randomized controlled trials on the prognosis and rehabilitation of femoroacetabular impingement syndrome. [ABSTRACT FROM AUTHOR]

A series of debates about health, ecology, and livestock production have been erupted in Taiwanese society since August 2020, following a decision by Taiwan's government to allow the importation of pork containing ractopamine from the United States. It becomes necessary to understand how the academic research results on ractopamine have been quoted and interpreted as the basis for discussing the debates. In this systematic review of literature along with bibliometrics, we designed a coding scheme for judging the positive and negative effects of ractopamine on health and ecology reported in the academic papers. A total of 511 articles were found in the Scopus between 2000 and 2020. According to the literature review, human health and ecological concerns are not the focus of mainstream academia. The analyses reveal that the positions of academic communities are obviously divided and lack consensus on the health and ecological stance of ractopamine. The mutual use of systematic literature review and bibliometrics can effectively explore the research characteristics of a huge amount of academic literature with limited time and research manpower, create a common knowledge base for stakeholders, and practice low-cost democratic participation in science and technology issues. This research suggests that for any controversial and risk-related technology policies, or in the early stages of policy discussion, a large-scale academic literature review should be conducted by a third-party organization in order to achieve transparent governance. [ABSTRACT FROM AUTHOR]

BACKGROUND: With the continuous accumulation of data resources around the world, the application of data visualization has become more urgent, and the methods of data visualization have also shown diversified characteristics. Data visualization is a scientific and technical research on the visual representation of data, which studies how to display relatively obscure data visually in a real and accurate way, to vividly and intuitively express the information and rules contained in the data. Literature is an important carrier of knowledge dissemination, with systematic characteristics, continuity, a large quantity and fast update, and is an important source of information. The visualization research of literature is of great significance to the dissemination of knowledge. At present, the visualization research of document data is mostly combined with the bibliometric analysis method, which visualizes the relationship between documents in the form of a scientific knowledge map. The application of this technology and method has played an important role in mining the information and rules contained in document data, but it is slightly insufficient in the spatial attribute mining of document data, which requires in-depth research in this field. OBJECTIVES: To provide new solutions for expanding the application of literature data in the field of spatial visualization, thereby further enhancing the usable value of literature data. METHODS: GIS technology was used to carry out the research on the spatial visualization method of document data, excavate the common content features and spatial features of document data, and gather the structured document data of a certain volume of spatial feature information to lay the data foundation for the visualization research. At the same time, the combination point between GIS technology and document data was studied, and the strategy and technical route for information mining and spatial visualization of document data were formed. Taking the data of more than 140 Re-Os isotope dating documents published since 2015 to 2020 as an example, the application test of this technical method was carried out. A Re-Os isotope data visualization service system with a five-tier architecture including layers of support, data, service, application and user has been developed, to realize the spatial visualization application of Re-Os isotope dating document data results. RESULTS: The results show that: (1) The study area contains more than 140 ore producing areas that carried out Re-Os isotope dating research from 2015 to 2020, covering the eastern, central, and western regions of China. (2) There are 19 main minerals in the study area, mainly copper (29. 0%), molybdenum (28. 3%), tungsten (12. 4%) and gold (11. 0%). (3) There are 12 kinds of detection objects, and the proportion of molybdenite as the detection object is 80. 7%, which indicates that molybdenite is still the preferred research object of the Re-Os isotope dating method, which is inseparable from the high Re / Os value of molybdenite. (4) The detection age falls in the lower age range of 0 - 200Ma, accounting for 62. 1% of the ore - producing areas, which are mainly distributed in the northeast and southeast regions of China, indicating that the Re-Os isotope ages in the eastern region are concentrated in the Mesozoic era, which is consistent with the existence of large - scale Mesozoic mineralization events in the eastern region of China. The ore - producing area in the age range above 200Ma accounts for 37. 9%, which is mainly distributed in the central and western regions of China, indicating that the Re-Os isotope ages in the central and western regions are concentrated before the Mesozoic era and have the characteristics of multiple mineralization. CONCLUSIONS: The research shows that the document data visualization technology and method proposed in this paper can be used to excavate the spatial characteristics of the document data, expand the application of the document data in the field of spatial visualization, and solve the problems of how to analyze and extract the common information of the document data, locate the spatial feature information, and realize the spatial visualization technology. In terms of revealing important target areas, key research minerals and main application technologies, it can provide spatial visualization information, and provide reference for finding the hot spots and difficulties of current metallogenic chronology research. [ABSTRACT FROM AUTHOR]

Objective To review the research progress, present the research status and analyze the evolution trend of hot spots through the bibliometric analysis of the research literature of cancer-related fatigue(CRF) at home and abroad. Methods We took CRF as the theme and the papers on CRF included in CNKI and WOS core database as the research object, and used VOSviewer and CiteSpace software as research tools, to make a visual atlas analysis on the research status and hot spot evolution at home and abroad. Results (1)Research status:①Literature: 3 646 papers (1 959 in English and 1 687 in Chinese) were finally included. The number of papers published at home and abroad showed an overall upward trend, and the proportion of foreign fund papers was high; ②domestic papers focused on nursing and rehabilitation. The research area of foreign papers was more extensive, diverse and integrated; ③Domestic cooperation was mainly small group cooperation, while foreign cooperation was more interdisciplinary and cross-team cooperation, forming a number of core teams and research institutions; ④ Domestic scholars paid attention to clinical application research and were good at learning from foreign countries and summarizing own experience. Foreign scholars paid more attention to basic research and the treatment was more systematic and standardized; ⑤There were a variety of diagnostic and therapeutic evaluation tools, mainly foreign scales. (2) Hot spot evolution: "quality of life" had always been a common topic of concern at home and abroad. Domestic scholars focused on clinical research and emphasized "treatment based on examination of causes" and "treatment based on syndrome differentiation". Foreign scholars attached importance to basic research and methodological research, and advocated non-drug intervention such as sports. In recent years, complementary and alternative medicine had become a hot topic in the international research. Domestic scholars had paid more attention to the research of mechanism and methodology, and expanded the application of TCM characteristic therapy in CRF. Conclusion Integrated traditional Chinese and Western medicine and multi-disciplinary participation are the future diagnosis and treatment mode of CRF. It's the direction of future efforts to establish CRF evaluation and management mode with TCM characteristic non-drug therapy as the core under integrated medicine. [ABSTRACT FROM AUTHOR]