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OBJECTIVE: Atrophic scar is the most common complication of acne, which has a great impact on patients' psychology and quality of life. Fractional CO2 laser combined with platelet-rich plasma shows promising therapeutic prospects. This study systematically evaluated the effectiveness and safety of fractional CO2 laser combined with platelet-rich plasma in the treatment of atrophic acne scars. METHODS: The Cochrane Library, PubMed, Web of Science, EMbase, CNKI, WanFang, VIP and Chinese Biomedical Literature Database were searched for literature related to clinical trials on fractional CO2 laser combined with platelet-rich plasma for the treatment of atrophic acne scar up to September 2022. Manual retrieval was conducted to complete the data. The included studies were screened and evaluated for literature quality by two researchers, and finally Meta-analysis was performed using Revman 5.3 software for the included studies, and descriptive analysis was used for data that could not be Meta-analyzed. RESULTS: A total of 13 studies involving 642 patients were included. Meta-analysis results showed that compared with the fractional CO2 laser alone group, the fractional CO2 laser combined with platelet-rich plasma group had significantly better overall response rate (odds ratio (OR)=3.95, 95% confidence interval (CI)=2.23 to 7.00, P < 0.000 01), better patient satisfaction (OR=4.19, 95% CI=1.05 to 16.76, P=0.04), shorter duration of erythema and edema (mean difference (MD)=-0.98, 95% CI=-1.19 to -0.77, P < 0.000 01; MD=-0.92, 95% CI=-1.36 to -0.48, P < 0.000 1 respectively), less post-inflammatory hyperpigmentation (OR=0.21, 95% CI=0.06 to 0.70, P=0.01), and shorter recovery time and total downtime (MD=-2.79, 95% CI=-3.28 to-2.30, P < 0.000 01; MD=-2.68, 95% CI= -3.15 to -2.21, P < 0.000 01, respectively). CONCLUSION: Fractional CO2 laser combined with platelet-rich plasma is more effective than fractional CO2 laser alone, with faster post-operative recovery and less adverse reactions such as erythema, edema and hyperpigmentation. [ABSTRACT FROM AUTHOR]

Objective: To systematically evaluate the relationship between periodontitis (PD) and the risk of erectile dysfunction (ED). Methods: The related researches between PD and ED were searched from the databases of Pubmed, Cochrane Library, Embase, CNKI, WanFang data and CBM from inception to October 2021. Odds ratio (OR) and corresponding 95% confidence intervals (CIs) were used to estimate the association between PD and the risk of ED. A meta-analysis was conducted using RevMan 5.1 software. Results: A total of 7 researches involving 215 991 participants were finally included. The result of meta-analysis showed that PD was associated with an increased risk of ED (OR=2.56, 95% CI: 1.55–4.24) as compared with the non-periodontitis populations, with a statistically significant difference (P=0.0002). The statistical heterogeneity was high across all studies (I 2 =99%). However，the combined effects were generally consistent with the sensitivity and subgroup analyses, showing a good stability of present effect. Conclusion: The current evidence indicates that PD increases the risk of ED, and PD might be a potential and important risk factor for occurrence of ED. However, limited by the quality and heterogeneity of the included studies, further prospective studies with high-quality are recommended to strength the evidence supporting the association between both diseases. [ABSTRACT FROM AUTHOR]

Objective To study the relationship between basilar artery remodeling pattern and plaque characteristics in correlation with acute cerebral infarction. Methods 86 patients with basilar artery stenosis admitted to our hospital from June 2018 to August 2021 underwent high—resolution 3.0 T MRI. The unenhanced and enhanced T1 VISTA of basilar artery stenosis were compared between the 39 patients (45.35q with and the 47 patients (54.65%) without infarct, between 40 patients (51.16%) with positive remodeling (PR) and 46 patients (48.83%) without PR (non—PR) The relationship between remodeling pattern and acute cerebral infarction was analyzed. Results In 39 patients with acute infarct, PR (61.70%), intraplaque hemorrhage (IPFI, 41.03%), significant plaque enhancement (58.97%), plaque size (7.07), and plaque load (28.72±10.99) were significantly greater (P<0.001, P<0.001, P<0.001, P< 0.001, P=0.007) than those of 37 patients without infarct (21.27%, 4.26%, 17.02%, 5.01, 20.96±14.33). In the 40 patients with PR, [PH (37.50%), significant plaque enhancement (52.50%), plaque size (8.24±2.60), and plaque load (32.46±8.86) were significantly greater (all P<0.001) than that of non—PR patients (6.52%, 21.74%, 3.95±3.61, 17.54±12.90). Multivariable analysis of acute cerebral infarction showed that IPFI was the strongest independent plaque feature of acute cerebral infarction with odds ratio of 18.408 and 95% confidence interval of 2.758-122.871 (P=0.003). Significant plaque enhancement was associated with acute cerebral infarction with odds ratio of 8.459 and 95% confidence interval of 2.321-30.831 (P= 0.001). PR was also associated with acute cerebral infarction with odds ratio of 5.761 and 95% confidence interval of 1.362-24.366 (P=0.017). The diagnostic value of PR in patients with acute cerebral infarction was 74.4% sensitive and 76.6% specific with 0.755 area under the receiver operating characteristic curve. Conclusion Basilar artery PR is associated with acute cerebral infarction and shows more plaque enhancement and IPFI than non—PR. [ABSTRACT FROM AUTHOR]