According to the subject characteristics of structural chemistry and the learning situation of undergraduates in Qufu Normal University, this paper explores the teaching reform to eliminate students' fear of difficulties and cultivate their interest in the subject. It is considered that designing a reasonable and interesting introduction course is an effective measure. The high-quality teaching effect and scientific thinking mode can be achieved by using the analogy method, reducing complexity to simplicity, and clarifying the scope, degree, logic and meaning of structural chemistry learning. [ABSTRACT FROM AUTHOR]