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In order to explore the influence of weak structural plane parameters on the dynamic response characteristics of slope under earthquake action. In this paper, the slope of an open-pit mine in Yunnan province is taken as the research background. The finite difference software is used to simulate the rock slope. A series of numerical simulation experiments are designed by the control variable method. The peak acceleration curve of the monitoring point in the elevation direction and the surface direction of the slope and the peak acceleration value are used to explore the influence of the change of the structural surface parameters on the dynamic response of the rock slope. Based on the orthogonal test and the range analysis method, the sensitivity analysis of the structural plane parameters affecting the dynamic response of the rock slope is carried out, and then the influence degree of each influencing factor on the dynamic response of the rock slope is ranked from large to small: structural plane cohesion> structural plane dip angle>structural plane internal friction angle>structural plane thickness. This study can provide a theoretical basis for the disaster prevention and control of rock slopes with weak structural planes under earthquakes. [ABSTRACT FROM AUTHOR]