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Objective: To explore the long-term effects of maternal pregnancy bisphenol A (BPA) exposure on emotional and behavioral problems appeared in their preschool children. Methods: The study sample was a subset of the China-Anhui Birth Cohort Study (C-ABCS). A unified questionnaire was used to collect basic information on both pregnant women and their children. Free BPA concentration in maternal serum was determined by high-performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS). The parent-report version of the Strengths and Difficulties Questionnaire (SDQ) was used to estimate the emotional and behavioral problems in preschool children. A total of 1 713 pairs of mothers and children were included in this study. Association between BPA exposure during pregnancy and the emotional and behavioral problems in preschool children was evaluated with multinomial logistic regression model. Results: Prevalence rates in 1 713 preschool children appeared as: 6.48% of emotional problems, 8.11% for conduct problems, 8.35% for hyperactivity/inattention, 2.86% for peer problems, 11.38% for prosocial behaviors and 7.94% for total difficulties. Subjects were divided according to the degrees of exposure and the results showed as: low exposure group (≤0.120 ng/ml), medium exposure group (0.120

Long non-coding RNAs (LncRNAs) are a class of RNA transcripts with a length greater than 200 nucleotides that generally have no or limited protein-coding capacity. They exist widely in eukaryotes and participate in epigenetic regulation, growth and development, immune response, metabolism and other life activities, and have become a new research hotspot in the field of life science in recent years. With a deepening understanding of the toxicological mechanisms of environmental pollutants, increasing evidence indicates that LncRNAs may play an important role in mediating the toxic effects of these pollutants. This review first briefly introduces the classification and biological functions of LncRNAs, and then focuses on the research progress of LncRNAs involved in stress responses to different types of environmental pollutants, including polycyclic aromatic hydrocarbons, polychlorinated biphenyls, poly brominated diphenyl ethers, benzene and bisphenols, per- and polyfluoroalkyl substances, pharmaceuticals and personal care products, pesticides, heavy metals, nanomaterials and PM2.5 . Finally, the future development direction of LncRNAs in the field of toxicology is prospected. This paper aims to provide a reference for further research on the molecular mechanism of LncRNAs in the toxic effects of environmental pollutants. [ABSTRACT FROM AUTHOR]

Bisphenol A (BPA) as an organic compound widely existing in the environment can interfere with the normal metabolism of the body and participate in the occurrence and development of a variety of diseases. High dose BPA exposure has an acute toxic effect on the reproductive system. Long-term exposure to BPA has more significant damage to the reproductive system, and can even produce intergenerational effects, affecting the growth and development of offspring. BPA damages female reproductive function and reduces female fertility through a variety of mechanisms. Therefore, it is particularly important to develop related drugs to alleviate this adverse reaction. This paper reviews the effects of BPA on female reproductive system, and introduces the research progress of antioxidants, probiotics, vitamins and traditional Chinese medicine on alleviating the effects of BPA on reproductive system. However, the clinical application of related drugs still needs the support of evidence-based medical evidence. [ABSTRACT FROM AUTHOR]

Environmental endocrine disruptors (EED) widely exist in daily life, as a kind of exogenous chemicals that can interfere with hormonal behavior. EEDs can bind to different receptors in the human body, to enhance or inhibit the normal endocrine function through a variety of mechanisms, resulting in a variety of diseases. The etiology of polycystic ovary syndrome (PCOS) is complex. Previous studies have shown that the pathogenesis of PCOS is related to environmental factors. The epidemiological and basic experiments showed that EEDs were involved in the pathogenesis of PCOS. However, it is necessary to study furtherly the potential mechanism. In this paper, the relationship between EEDs and PCOS, as well as possible mechanism, was expounded. It provides a new clue for those people to block the development of PCOS by improving their lifestyle. [ABSTRACT FROM AUTHOR]