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Bisphenol A (BPA) is an endocrine disrupting chemical that destroys the endocrine system and leads to metabolic disorders. BPA has been widely concerned due to its ubiquity in the environment and damage to health. Previous studies have focused on the physiological functions of BPA involved in obesity, reproductive system disorders, and carcinogenesis. BPA is generally recognized as a xenoestrogen so that plays an important role in the regulation of bone, a hormone-sensitive tissue. However, underlying mechanism is still under debate. This article reviews the research progress on the effects of BPA on osteogenic differentiation and bone mineral density and its molecular mechanism. [ABSTRACT FROM AUTHOR]