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【Objective】 The present paper aimed to investigate the comprehensive effects of irrigation amount on soil enzyme activity, yield, quality and nutrient utilization of pepper in Sichuan Basin, and propose an appropriate irrigation amount. 【Method】 The pepper variety of Xingshuzhoula 3 was used as the experiment material. Four irrigation amount treatments were set, and the soil volumetric moisture content was controlled respectively at 35%-40% (T1), 45%-50% (T2), 55%-60% (T3), 65%-70% (T4). The soil urease, neutral phosphatase, sucrase β-Glucosidase activity and catalase activity such as yield, quality, and plant N, P, K content of peppers were determined. The interrelationship between the indicators was analyzed. 【Result】 The soil enzyme activities increased with the increase of irrigation amount. The soil urease, neutral phosphatase, sucrase, β-glucosidase and catalase activities of T4 were the highest, and the activities of some enzymes were not significantly different from those of T3.Compared with T1, the increases were 48.80%, 28.70%, 45.60%, 100.87% and 102.58%, respectively. With the increase of irrigation amount, pepper yield also increased, T4 increased by 29.05% compared with T1, and there was no significant difference in pepper yield between T3 and T4.The content of vitamin C and capsaicin in peppers decreased gradually with the increase of irrigation water, but the content of soluble sugar in peppers increased with the increase of irrigation water. The amount of irrigation increased the total accumulation of nutrients (N, P and K), the physiological use efficiency of N and K and the partial fertilizer productivity in pepper fruits and shoots. Except that the physiological utilization efficiency of P was lower than that of T4, the other nutrient utilization parameters of T3 were not significantly different from those of T4, and the physiological utilization efficiency of K was even significantly higher than that of T4.【Conclusion】When the irrigation amount is 4392-4733 t/hm² (T3 and T4), the soil enzyme activity, yield and nutrient utilization rate of pepper are all at high levels. The results of the study provide a theoretical and practical reference for the selection of the irrigation amount of facilities pepper in Sichuan Basin. [ABSTRACT FROM AUTHOR]