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Water vapor in natural gas often leads to the decrease of gas calorific value per unit volume; it also reduces the flow area of pipeline. Moreover, the CO2 and H2S will corrode the pipeline when dissolved in liquid water. According to the containing water problems in high pressure natural gas during development, a roof-mounted type supersonic cyclone flow natural gas dehydration unit was designed in combination with the fluid mechanics and engineering thermodynamics principle. Based on the research status at home and abroad, the supersonic natural gas condensate flow numerical model was built, including multicomponent two-phase expansion flow model and water vapor condensing model. The flow characteristics of each work section of supersonic natural gas dehydration unit were numerical analyzed, and the device internal pressure, temperature, Mach number, vapor nucleation rate, moisture distribution were obtained. According to the results of numerical simulation, optimization design was carried out to improve the efficiency of separation. [ABSTRACT FROM AUTHOR]