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BACKGROUND: Patellofemoral pain syndrome is a common disease in the field of sports injuries. Research in and outside China is increasing year by year, but there is no visual analysis for patellofemoral pain syndrome. OBJECTIVE: To objectively analyze the literature research on patellofemoral pain syndrome in and outside China in the past 13 years, to summarize the recent research directions in this field and to sort out the knowledge structure in and outside China. METHODS: Relevant articles on patellofemoral pain syndrome were collected from Web of Science and CNKI. Citespace software was used for visual analysis to show the research hotspots and development trends of this field. RESULTS AND CONCLUSION: (1) A total of 1 679 articles were finally included in the Web of Science database. The authors with the most articles are De Oliveira Silva D from La Trobe University in Melbourne, Australia and Crossley KM from the University of Melbourne, Australia. Hot keywords are hip, biomechanics, prevention (prognosis), prevalence disease rate, consensus statement, gender differences, electromyographic activity, risk factor, and osteoarthritis. (2) A total of 214 articles were included and analyzed in the CNKI database. The author with the most articles is Miao Ping from the Rehabilitation Department of the Second Affiliated Hospital of Guangzhou Medical University. Hot keywords are arthroscopy, biomechanics, strength training, lateral femoral muscle, surface electromyography, patellofemoral arthritis, and joint replacement. (3) International research hotspots show the biomechanical characteristics of increased knee external rotation, increased hip adduction, and decreased hip internal rotation during patient exercise. Strengthening the hip abductors and external rotators can effectively improve the pain and function of patients. At present, the most appropriate method to treat the disease in the world is a customized multi-modal intervention program, including strengthening of the gluteal muscles and quadriceps, emphasizing education and activity adjustment. (4) The results of major Chinese studies in this field confirm that the use of arthroscopic surgery can improve the pain of patients with patellofemoral pain syndrome, and patellofemoral joint replacement has a certain effect on early severe patellofemoral arthritis in such patients. Rehabilitation training methods are mainly based on hip joint strength training, supplemented by core muscles, lower limb eccentric strength and neuromuscular control training. Compared with foreign countries, the unique research hotspots in China are acupuncture and Chinese medicine. [ABSTRACT FROM AUTHOR]

BACKGROUND: Biological three-dimensional (3D) printing technology has been extensively utilized in numerous fields of biomedicine. However, not many cases have been successfully transformed into clinical trials. It is still in the development stage in precision medicine. This technology reveals great potential in realizing individualized medical treatment, changing the existing treatment process, and helping pharmaceutical and medical companies develop more accurate drugs. Furthermore, it is expected to accomplish the closed-loop from individualized information collection and diagnosis to individualized medical product preparation and precise treatment scheme. OBJECTIVE: To analyze the current research and hotspots of biological 3D printing technology in precision medicine. METHODS: Web of Science and Wanfang databases were searched for literature on 3D printing technology in precision medicine published from January 2015 to August 2020. The retrieval results received scientific quantitative analysis through big data analysis tools, mathematical statistics, computer semantic analysis, visualization software, and database analysis and retrieval. RESULTS AND CONCLUSION: (1) The amount of studies on 3D printing technology in the field of precision medicine gradually increases from 2015 to 2020. (2) The United States has the largest amount of publications, and its cooperation with other countries also occupies a core position. The research in China is also active in this field. (3) The institution that published the most papers in the world in the past five years is the University of California system, while the Chinese Academy of Sciences and Shanghai Jiao Tong University are the Chinese institutions with the highest number of publications. (4) Biofabrication and Chinese Journal of Tissue Engineering Research are the journals with the largest number of publications in the world and in China, respectively. (5) The hotspots of biological 3D printing technology in precision medicine mainly include bioinks, microfluidics, orthopedics, tissue/organ regeneration, and drug development. The research results published in Chinese journals are mainly concentrated in the fields of orthopedics, tissue engineering, clinical teaching, and medical models. (6) As one of the most revolutionary and influential advanced tools, biological 3D printing has achieved some accomplishments in regenerative medicine and organ transplantation. It has become an excellent scientific research tool in tissue engineering, stem cells, and cancer, and has created a way for precision medicine from medical imaging, preoperative plan to implant design and manufacture through digital tools. [ABSTRACT FROM AUTHOR]

BACKGROUND: In order to solve the problem that the clinical application of liver transplantation is limited by the shortage of supply sources of liver, scientists from all over the world are actively exploring and have successively studied and developed technical means such as artificial liver, tissue-engineered liver and xenotransplantation. It can be used as a corrective or alternative treatment for liver failure. OBJECTIVE: To expound the development history, research status and future expectation of repair and alternative treatment for liver failure. METHODS: Relevant articles published from 2000 to 2019 were searched in the Web of Science and WanFang databases. The keywords were "active liver, liver tissue engineering, hepatic failure" in English and Chinese, respectively. RESULTS AND CONCLUSION: For advanced liver diseases such as liver failure, there are some repair and alternative treatments, including in situ liver transplantation, cell transplantation, artificial liver system, and tissue-engineered liver. To date, a number of hospitals and institutions in China have independently developed artificial liver devices. Although bioartificial liver and mixed artificial liver have shown good prospects in the treatment of liver failure, most of them are still in the experimental stage of animals. Further investigations on the development of bioreactors to enhance cell survival in scaffolds are necessary. Tissue-engineered liver constructed by biological materials and seed cells can to some extent simulate the physiological functions of liver synthesis, detoxification, metabolism, and secretion, which can be transplanted into the body to treat end-stage liver disease. It is a research hotspot in the field of tissue function. Efforts to solve the clotting problem and to promote the vascular formation of scaffold are warranted in this field. Xenograft is the best way to solve the serious shortage of human organ donors, but there is still a long way for this technique away from clinical application. [ABSTRACT FROM AUTHOR]