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In response to the issues in the teaching of the medicinal chemistry course, we propose an innovative teaching approach based on a higher-order skills-oriented advanced research-oriented learning model. By combining the P-MASE research-oriented learning model with advanced instructional activity design, we create a higher-order skills-oriented teaching activity that integrates "interesting case research + creative research activities + project challenges", and construct a teaching scenario that incorporates the instructional content. Under the guidance of teachers, students advance their research-oriented learning in medicinal chemistry through the P-MASE framework, which involves problem identification, method exploration, scientific analysis, effective solution, and evaluation of outcomes. This approach facilitates theoretical development and enhances students' research and innovation thinking skills. Through an analysis of the achievement of the medicinal chemistry course, it is confirmed that this model can effectively enhance the higher-order nature, innovation, and challenge of the course. [ABSTRACT FROM AUTHOR]