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The research progress in thermal aging resistant silicone rubber based heat-proof materials in recent years was reviewed with 46 references. The inorganic modification effects of nano-carbon materials, graphite powder, talc powder, transition metal oxides and fiber fillers on the thermal aging resistance and mechanical properties of silicone rubber based heat-proof materials were emphatically introduced, and the main research directions of thermal aging resistant silicone rubber based heat-proof materials in the future were pointed out.

Objective To compare the effects of 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP)- and silane-based primers with those of MDP-based primers on zirconia-resin bonding via multiple levels of aging. Methods Zirconia blocks were divided into 4 groups (n = 21) according to the primer used: MDP-based Z-Prime Plus (ZP), silane-based Monobond-S (MS), MDP- and silane-based Clearfil Ceramic Primer (CCP) and no primer (Blank). After pretreatment with or without the primers followed by bonding with cement Duo-Link, each group was subdivided into 3 subgroups (n = 7) according to aging level: 24 hours of water storage at 37 ℃ (24 h), 30 days of water storage at 37 ℃(30 d), and 30 d plus 3 000 thermal cycles (30 d/TC). After aging, shear bond strength (SBS) tests and failure mode analyses were conducted. Results ZP, MS and CCP groups had greater SBSs than did the BLANK group (PPPvs. 24 h, PPP = 0.029) but lower than that of MS at 30 d/TC (P = 0.037). From 30 d to 30 d/TC, the percent decrease in the bonding strength of ZP was significantly greater than that of MS (82.43% vs. 64.90%). Conclusion MDP-based primers function better for zirconia-resin bonding when they contain silane coupling agents.

A case of Bowen's disease of toe is reported. A 39-year-old woman presented with red asymptomatic lesion on the medial side of the left big toe for over a month. Topical treatment with glucocorticoid was not effective. A similar rash appeared on the same area 5 to 6 years ago, and was surgically removed. Clinical examination revealed a demarcated red plaque 1.5 cm×1.5 cm in diameter, with dark red crust in the center, on her big left toe. The histopathological examination of the skin lesion showed heteroplasia of the squamous epithelium in the epidermis. The diagnosis was Bowen's disease. Following removal of lesion with electrocauterization, 5-aminolevulinic acid photodynamic (ALA-PDT) was given 4 times. The lesion completely subsided with no recurrence during 1-year telephone follow-up.

With the continuous innovation of genomics, proteomics and molecular biological detection technology, the treatment of non-small cell lung cancer (NSCLC) has changed from traditional chemotherapy to immunotherapy and targeted therapy. Among them, molecular tumor markers targeting tyrosine kinase pathways play more important roles in clinical practice. For advanced NSCLC patients with positive epidermal growth factor receptor (EGFR) mutations, there are many first-line drugs on the market and they could bring significant efficacy, thus completely subverting the treatment pattern of advanced NSCLC. Common mutations of EGFR in Chinese patients are located on exons 19, 20 and 21, of which exons 19 and 21 mutations are the more common types. Besides, there is also a subtype of EGFR mutations, known as EGFR 20 exon insertion (EGFR 20ins) mutation. The authors summarized the treatment of a lung adenocarcinoma patient with EGFR 20ins mutation accepting Furmonertinib mesylate, in order to provide effective references for clinical diagnosis and treatment.

The process of extracting seleno-protein from the selenium enriched Lyophyllum decastes mycelia cultured in a 20 L fermentor was optimized, and the effects of selenium enrichment on both types and contents of amino acids in Lyophyllum decastes mycelia were analyzed. Single factor tests and Box-Benhnken central combined response surface test were used to optimize process of extracting seleno-protein from Lyophyllum decastes mycelia. The content of protein was determined by 3,3'-diaminobenzidine spectrophotometry. The types and contents of amino acids in mycelia protein before and after selenium enrichment were compared by means of amino acid analyzer. The results showed that the optimal conditions of extracting seleno-protein from mycelia of Lyophyllum decastes were extraction temperature of 64 ℃, extraction time of 60 min, liquid-solid ratio of 200:1 g/mL, and extraction times of 2. The protein extraction rate was 75.13%, and the content of selenium in mycelia was 63.87 μg/g. The amino acid composition were analyzed by means amino acid score (AAS) and chemical score (CS), and the nutritional value of the protein in the selenium-enriched Lyophyllum decastes mycelia was evaluated. The varieties of amino acids in the selenium-enriched Lyophyllum decastes mycelia were abundant and the content of essential amino acids for human body was 17.20 g/100 g, 19.75% higher than that in the non-selenium-ecriched Lyophyllum decastes mycelia. The ratio of EAA/NEAA was 0.51, close to the recommended value proposed by WHO, and the values of both AAS and CS were close to the those in the model protein. In summary, the protein extraction rate could be improved by optimizing the extraction process, and there was selenium in the protein from selenium-enriched mycelia, which promoted the increase of amino acid content. The nutritional value of protein in selenium-enriched mycelia was higher than that in non-selenium-riched mycelia, and selenium-enrichec mycelia had potential edible and application value.

Background Currently, there is a lack of clinical competence evaluation tools applicable of general practitioners (GPs) practicing in rural settings in China, resulting in the lack of researches on the clinical competence evaluation of GPs in rural. Objective To explore reliability and validity of an evaluation index system for consultation competency of rural GPs developed previously, and provide an evaluation tool with high reliability and validity for scientific and objective assessment of consultation competence of GPs in rural settings. Methods Based on the evaluation system for consultation competency of rural GPs, a corresponding questionnaire was designed, and points were assigned to each option on a 5-point Likert scale. From September to December 2022, GPs or assistant general practitioners (AGPs) who were working in rural township health centers in Guangxi Province were recruited as the research subjects by using the purposive sampling and stratified sampling methods, the questionnaire was distributed through a national web-based survey platform-"WJX" to them. Cronbach's α coefficient, split-half coefficient, critical ratio (CR) and correlation coefficients were calculated based on questionnaire data. Confirmative factor analysis was employed to fit questionnaire data and assumed model, and calculate three categories of indicators, including preliminary fit criteria (PFC), overall model fit (OMF), and fit of internal structural model (FISM), to verify the degree of fit and structural validity of the measured data. Results A total of 600 questionnaires were distributed and 366 were validly collected, with an effective recovery rate of 61.0%, 86.1% were registered as GPs and 13.9% as AGPs, who came from five cities, including Nanning, Guilin, Wuzhou, Baise, and Guigang, and 204 township health centers in Guangxi Province. Cronbach'α coefficient for the whole questionnaire or for every section was higher than 0.700, and Guttman Split-Half coefficient was 0.931. The initial first-order model met the PFC well; except for goodness of fit index (GFI), adjusted goodness of fit index (AGFI), and normed fit index (NFI), other indicators related to the OMF reached for the best levels in the modified first-order model. Apart from R2 for 9 observable variables less than 0.5, the FISM for the modified first-order model showed good effects. The initial second-order model indicated as similar effects on the PFC as the initial first-order model; the modified second-order model shared similar OMF with the modified first-order model; the modified second-order model was inferior to the modified first-order model in terms of the FISM. Eventually, questionnaire data fitted the modified first-order model better. Conclusion The evaluation index system for consultation competency of rural GPs shows high reliability and validity, which can be used for research and practical work on the evaluation of consultation competence evaluation of GPs in rural settings.

Background Training general practitioners (GPs) and improving the practice competence of "GP-centered" primary health care personnel are important directions of the development of human resources for primary health care in China. At present, there is lack of an index system applicable to evaluate clinical competence of GPs in the circumstances of primary health care in China, which not only hampers accurate identification of gaps in clinical competence of GPs, but also impedes sustainable improvement of the education and training of GPs as well as primary health care personnel. Objective To develop an evaluation index system for consultation competency of GPs in the circumstances of primary health care in China based on the original version of Leicester Assessment Package (LAP), so as to provide an index model reference for the objective evaluation of consultation competency of GPs. Methods Between May to August in 2022, a total of 15 experts were invited by using the purposive sampling method to implement the Delphi method by correspondence, to evaluate the importance, feasibility, and textual representation of each index in the initial evaluation index system for consultation competency of GPs. Analytic hierarchy process was adopted to calculate weight and combined weight for the first-level and secondary-level indexes. Results A total of two rounds of Delphi were conducted. The positivity coefficient, familiarity level, judgment coefficient, and authority coefficient were 100%, 0.77, 0.91, and 0.84 in both rounds of consultation; the mean score of the importance and feasibility of each indicator was 3.5, and the variation coefficient was 0.3. The Kendall coefficients for the importance and feasibility of the indexes in the two rounds of consultation were statistically different (P

Single Side Band (SSB) direct detection system is considered as an attractive solution for 80 km Data Center Interconnects (DCI), due to its characteristics of low-cost, simple system architecture, and high robustness to chromatic dispersion. However, Signal to Signal Beating Interference (SSBI) is the major problem in SSB direct detection system. In order to address the SSBI in the SSB direct detection systems, the SSB modulation realized by IQ modulator and Dual Drive Mach Zehnder Modulator (DDMZM) is investigated. A SSB signal reconstruction algorithm based on time domain iteration and an SSBI-free direct detection scheme based on DDMZM are proposed respectively for these two SSB direct detection systems. The implementation principle and simulation or experimental setup are introduced in detail. According to the simulation and experimental results, the effectiveness and feasibility of the two schemes in SSBI elimination are discussed.

Background and purpose: Placental site trophoblastic tumor (PSTT) is a rare type of malignant tumor. Because of its unique mode of invasion in the uterus and its insensitivity to chemotherapy, total hysterectomy is the primary recommendation. The purpose of this study was to investigate the feasibility and safety of conservative surgical treatment in patients with stage Ⅰ PSTT. Methods: The patients with stage Ⅰ PSTT admitted to Obstetrics and Gynecology Hospital of Fudan University from January 2015 to December 2021 were included, and those published on Pubmed and China National Knowledge Infrastructure (CNKI) from January 1990 to December 2021 were searched with the keywords of “placental site trophoblastic tumor” and “case”, “placental trophoblastic tumor” and “case” respectively. The clinicopathological data of the patients were collected and retrospectively analyzed. Results: A total of 10 cases admitted to Obstetrics and Gynecology Hospital of Fudan University were enrolled. The median age was 27 years. The most common symptom was irregular vaginal bleeding (70.0%). The median time of interval since antecedent pregnancy (ISAP) was 14.5 months. The median level of β-human chorionic gonadotrophin (β-hCG) was 124.51 mU/mL, and the diameter of the focus was 0.8-8.0 cm. All 10 patients admitted to Obstetrics and Gynecology Hospital of Fudan University achieved complete remission after initial treatment. The average follow-up time was 48.1 months and there was no recurrence. Three patients became pregnant naturally after treatment, including 2 cases of full-term pregnancy and delivery and 1 case of induced abortion because of unplanned pregnancy. Literature review of PSTT cases showed similar clinicopathological distribution and disease outcome. Conclusion: Conservative surgery could be an alternative choice for selected patients with stage Ⅰ PSTT, but more research is needed to provide evidence.

In order to investigate the mechanical properties of uncured rubber, uniaxial and cyclic tensile experiments are conducted on uncured rubber at different strain rates. From the experimental results, the rate-dependent nonlinear mechanical behaviors of uncured rubber can be clearly observed. With strain rate increasing, the stress level, hysteresis and Mullins effect get enhanced, and the residual strain decreases. To characterize the nonlinear visco-elastoplastic mechanical behaviors of uncured rubber, a three-network (TN) constitutive model that contains a hyperelastic network and two nonlinear viscoplastic networks is proposed. The eight-chain model is used to characterize the hyperelastic behavior while the Bergstr?m-Boyce flow model is applied in the viscoplastic networks to capture the nonlinear viscous flow. The proposed constitutive model is implanted into the finite element software Abaqus with which, the multistep tensile relaxation test is simulated. The simulation result is satisfactorily consistent with experimental results, which verifies the effectiveness of the TN model. Finally, the simplified molding process of a tire tread is simulated, which further verifies the stability of the TN model.

Objective: To investigate the toxin-encoding genes and antibiotic susceptibility of Staphylococcus aureus isolates from retail vegetables consumed raw. Methods: The 27 S. aureus isolates from tomato, lettuce, spinach and cabbage collected from supermarkets, farmers’ markets and vendors in Xi’an, Baoji, Hanzhong and Yan’an of Shaanxi province were identified by PCR amplification of the nuc gene, the prevalence of 19 toxin-encoding genes and 12 antibiotic resistance encoding genes in these isolates was evaluated, and the antibiotic susceptibility to 14 antibiotics was determined by the agar dilution method. Results: Seventeen of these isolates were identified as methicillin-susceptible S. aureus (MSSA) and the remaining 10 isolates were identified as oxacillin-susceptible methicillin-resistant S. aureus (OS-MRSA). A total of eight toxin-encoding genes were detected in the 27 isolates, and the detection rate (29.6%, 8/27) of sec was highest. In addition, 51.9% (14/27) of these isolates carried at least one toxin-encoding gene, and nine toxin-encoding gene profiles were totally identified. Seven antibiotic resistance genes including blaZ, mecA, ermC, tetK, dfrG, dfrK, and aac(6’)/aph(2”) were detected. The isolates were all susceptible to oxacillin, rifampicin and vancomycin. Resistance to amoxicillin/clavulanate was most commonly detected, followed by trimethoprim/sulfamethoxazole, ampicillin, erythromycin, cefoxitin, ciprofloxacin, ceftriaxone, gentamicin, amikacin, tetracycline and chloramphenicol. Twenty-four (88.9%) isolates were resistant to three or more antibiotics. Conclusion: OS-MRSA is prevalent in vegetables consumed raw in Shaanxi province, and it has multiple antibiotic resistances and carries multiple toxin-encoding gens, posing a potential food safety hazard.

Micro-area electrochemical measurement technique can detect metal galvanic corrosion in situ at the micron or even sub-micron scale, which provides a new way for further study of metal galvanic corrosion. In this paper, the basic principle and main influencing factors of metal galvanic corrosion were introduced. The advantages, disadvantages and application status of commonly used micro-area electrochemical measurement techniques such as wire beam electrode (WBE), localized electrochemical impedance spectroscopy (LEIS), scanning vibrating electrode technique (SVET), scanning electrochemical microscopy (SECM), and scanning Kelvin probe (SKP) were reviewed in metal galvanic corrosion research. Finally, the future development of the micro-area electrochemical measurement technique was prospected.

为了对比不同油体富集物理化性质及功能性质的差异，采用水萃离心法从大豆、花生、葵花籽3种大宗油料种子中提取油体富集物，对比研究了油体富集物的得率、基本成分、粒径、Zeta电位、蛋白质组成、黏度、起泡性、乳化性、分层稳定性以及冻融稳定性。结果表明：大豆油体富集物的得率和固形物含量都显著低于葵花籽和花生油体富集物的（p＜0.05），且具有不易掩盖的豆腥味；3种油体富集物的基本成分之间都存在显著性差异（p＜0.05），蛋白质的分子质量分布也不尽相同；3种油体富集物的粒径和Zeta电位绝对值由小到大顺序均为大豆油体富集物

For the problem of inhomogeneity of the output optical power of multiple output ports, the paper designs a 1×4 Multimode Interference (MMI) coupler based on Silicon-On-Insulator (SOI) and proposes a new method to optimize its homogeneity. A tapered waveguide is used at the input/output of the coupler. To improve the uniformity of the MMI coupler, an unequal-width design is used for the tapered waveguide at the output. After optimization, the uniformity of the four output ports is as high as 0.007 4 dB, while the total insertion loss is only 0.058 dB. According to this method, the transmission constant of the output, avoid crosstalk between waveguides, and achieve an improvement in the uniformity of the output port of the MMI coupler.

Hashimoto's thyroiditis （HT） is an autoimmune disease triggered by environmental factors on the basis of genetic susceptibility. Trace elements are an important part of environmental factors， among which iodine excess， selenium deficiency， magnesium deficiency and vitamin D deficiency are the risk factors inducing the incidence and progression of HT. The mechanism of HT induced by these nutritional factors is related to the activation of thyroid autoimmune response， oxidative stress response and inflammatory response. For HT susceptible population and HT patients， rational dietary guidance should be given， and corresponding nutritional supplements should be delivered when necessary， aiming to delay the incidence and progression of HT.

[Objective] The changes and differences in landscape structure and network connectivity of ecological land in Nanchang City, Jiangxi Province under different development scenarios in the future in order to provide a reference for environmental protection planning and project construction in Nanchang City. [Methods] Based on the PLUS model, the future ecological land use pattern of Nanchang City was predicted for multiple scenarios. Differences in landscape structure and network connectivity of ecological land in different regions and the structures of the city under different development intensities were studied from the perspectives of quantity and structure through landscape pattern index, morphological spatial pattern analysis (MSPA), and network connectivity analysis. [Results] ① Under different development scenarios, the destruction of ecological land was mainly concentrated in Anyi County and Xinjian District; ② The fragmentation of grassland was very serious, and there was little difference in landscape structure under any development scenario. The difference in landscape index between forest land and water area was small under the ED and EP scenarios, showing strong resistance to medium and high intensity development; ③ Under different development scenarios, the difference in ecological core area was as high as 90.36 km2. Ecological land with multiple types of uniform mixed structure can effectively suppress the generation of isolated islands and maintain regional ecological security; ④ Compared with 2020, under various scenarios, the equivalent possible connectivity index EC (PC) of Nanchang City decreased by 18.76%~23.24%, and the network connectivity in Xinjian District and Anyi County decreased significantly. [Conclusion] The ecological protection scenario (EP) development plan can effectively protect the ecological landscape structure and network security of Nanchang City, thereby ensuring the sustainable development of the city. At the same time, when carrying out ecological protection planning and restoration projects, priority should be given to the construction of new areas, Anyi County, and other fragile ecological landscape areas so as to better maintain the ecological security of Nanchang.

Stress corrosion is one of the main threats to titanium alloys used in marine equipment.In order to provide technical support for the safe service of marine equipment，the TC4ELI titanium alloy used in marine environment was selected as the research object，and its corrosion behavior in 3.5%NaCl solution under different microstructure states was systematically studied by using WOL (wedge-open loading) specimen and static displacement method to measure KISCC.The fracture morphology and crack propagation path of the stress corrosion specimens were observed by optical microscope (OM) and scanning electron microscope (SEM).The element distribution of the crack site was analyzed by secondary ion mass spectrometry (SIMS).Results indicated that the stress corrosion threshold (KISCC) of duplex microstructure (α＋β) sheet was 56.01 MPa·m1/2，and the stress corrosion threshold (KISCC) of Widmannstetter structure sheet was greater than 67.48 MPa·m1/2.The fracture surface of stress corrosion specimen was mainly composed of matrix，fatigue preformed zone and tearing zone.There was a stress corrosion zone at the interface between fatigue preformed zone and tearing zone of duplex microstructure specimen.In addition to the main crack，there were some secondary cracks at the crack tip for duplex microstructure specimen.There was no obvious stress corrosion cracking (SCC) feature in Widmannstetter structure specimen.The stress corrosion resistance of the Widmannstetter microstructure was better than that of duplex microstructure.The stress corrosion cracking of TC4ELI alloy duplex microstructure specimen was mainly transgranular fracture，and the hydrogen was easy to accumulate at the crack tip.

Wind power generations are widely used in power system as a type of clean renewable energy. However, the random fluctuation of wind power output has a negative effect on the power quality of power system. The energy storage system has been applied to suppress the voltage and power fluctuation by wind power access to power system because of its flexible bidirectional regulation ability. In this paper, a multi-objective energy storage optimal allocation model is established based on system voltage deviation, daily active power loss and total energy storage access capacity as the objective function. A beetle antennae search-improved multi-objective particle swarm optimization (BAS-IMOPSO) algorithm which is formed by combining BAS and IMOPSO is used to solve the model, and the optimal energy storage allocation scheme is selected in Pareto solution set by using the technique of order preference by similarity to ideal solution based on information entropy. The proposed model has been applied to IEEE 33-node distribution system. The simulation results show that the energy storage system optimized by BAS-IMOPSO algorithm has significantly higher ability to reduce voltage deviation and active power loss of distribution network than MOPSO algorithm does, and it can effectively improve the power quality with the ability of peak load shifting. The model shows the effectiveness of the proposed BAS-IMOPSO algorithm.

Few studies have focused on the effects of injection time and hydrostatic pressure on the solute transport in porous geothermal reservoirs to date. The chloride displacement experiments were individually carried out at 35 °C at the injection time of 1 h, 2 h, 3 h, 4 h and 5 h individually through the simulated columns packed with the thermal reservoir fine sand. Column experiments were performed at 35 °C at hydrostatic pressure of 0, 6 and 9 MPa individually. By using the one-dimensional CDE model in the CXTFIT 2.1 software, the migration law of Cl− and its influencing factors in the studied matrix were examined. The results show that the Cl− breakthrough curves under different injection time and hydrostatic pressure are symmetrically distributed, and they can all be well described by the CDE model. Thus, the solute dispersion can conform to the Fick’s law in the simulated low-temperature pore geothermal water. The breakthrough curve and transport parameters of Cl− are highly correlated with the injection time due to the variations of the total amount of solute mass injected, concentration differences and molecular diffusion ability in the studied geothermal water. In addition, the value of D increases from 25.22 cm2/h at 0 MPa to 36.13 cm2/h at 9 MPa, combining with the increasing molecular diffusion coefficient, dispersion coefficient and dispersivity with hydrostatic pressure. Hence, the solute hydrodynamic dispersion in the simulated sandy column are enhanced with the increasing hydrostatic pressure. The results are of great significance to enrich the theory of solute transport in groundwater.

Background There is an issue of mismatch between supply and demand of medical care resources in China. The implementation of contracted family doctor services is an effective measure to address the issue, and to improve the hierarchical diagnosis and treatment system. Therefore, it is urgent to speed up the training and ensure the training quality of general practice workforce. Objective To develop a comprehensive and systematic general practitioner (GP) competency model after analyzing the concept and structural domains of competencies (including inner competencies) required for GPs to deliver contracted healthcare services, providing insights into the realization of training eligible GPs in terms of quantity and quality, and the improvement of quality and efficiency of contracted services. Methods From December 2020 to September 2021, we conducted in-depth, semi-structured interviews with 38 GPs from 10 medical institutions in four cities (Zhenjiang, Taizhou and Suzhou in Jiangsu Province, and Foshan in Guangdong Province) , then treated the interview results applying the three-level coding and theoretical saturation used in the grounded theory. After that, we developed a General Practitioner Competency Model. Results The model consists of 10 items, which belong to four domains: general care capability, humanistic practice capability, team cooperation capability, learning and development capability. General care capability and learning and development capability belong to external competencies, which represent the external performance and driving force of competencies, and determine the level of competencies of GPs to provide contracted services. Humanistic practice capability and team cooperation capability reflect the internal traits and competencies, which belong to the inner competencies, and determine the potential of GPs to provide contracted services. Conclusion The model developed by us is complete and comprehensive, in which the inner competencies of GPs have been fully explored, which may be contributive to the training of GPs delivering contracted services, and to the development of a GP competency assessment system using quantitative empirical methods.

为了探究葵花籽油体富集物在冰淇淋中应用的可行性，以葵花籽油体富集物作为脂肪来源制备低脂冰淇淋，在无均质条件下研究葵花籽油体富集物添加量对低脂冰淇淋浆料和产品品质的影响。结果表明：冰淇淋浆料的黏度、储能模量和损耗模量都随葵花籽油体富集物添加量的增加而增大，当葵花籽油体富集物添加量为3.5%～4.0%时黏度与对照组相当；浆料中不易流动水和结合水的比例随着葵花籽油体富集物添加量的增加逐渐增大,在4.0%时达到最大；冰淇淋的膨胀率和抗融率随着葵花籽油体富集物添加量的增加先增大后减小；添加葵花籽油体富集物的冰淇淋色泽较差；冰淇淋的硬度和咀嚼性变化规律一致，都是随着葵花籽油体富集物添加量的增大呈现先减小后增大的趋势，弹性变化则相反;冰淇淋黏附性随着葵花籽油体富集物添加量的增加而升高；葵花籽油体富集物添加量为2.5%时冰淇淋感官评分最高。合适的葵花籽油体富集物添加量可以起到与棕榈油相似的效果，因此葵花籽油体富集物可以应用在冰淇淋中。In order to investigate the feasibility of using sunflower seed oil body enrichment in ice cream,low fat ice cream was prepared with sunflower seed oil body enrichment as the fat under the condition of non-homogenization. The effect of the dosage of the oil body enrichment on the quality of low fat ice cream slurry and product was explored. The results showed that the viscosity, storage modulus and loss modulus of ice cream slurry increased with the increase of the oil body enrichment dosage. When the dosage of oil body enrichment was 3.5%- 4.0%, the viscosity was equivalent to that of the control group. The proportion of non-flowing water and bound water in the slurry increased gradually with the increase of the dosage of oil body enrichment, reaching the maximum at 4.0%. The expansion rate and anti-melting rate of ice cream products first increased and then decreased as the increase of the oil body enrichment dosage. The color of ice cream with sunflower seed oil body enrichment was poor. The hardness and chewability of ice cream showed the same change law, which first decreased and then increased with the increase of the oil body enrichment dosage,while the elasticity changed in the opposite direction. The adhesion of ice cream increased with the increase of the oil body enrichment dosage. The sensory score of ice cream was the highest when the dosage of oil body enrichment was 2.5%. The appropriate dosage of sunflower seed oil body enrichment can produce a similar effect as palm oil, and sunflower seed oil body enrichment can be applied in ice cream.

Industrial security issues have always been an important and urgent issue globally.Industrial control protocols are widely used in the communication between industrial control system(ICS) components.Their security is related to the safe and stable operation of the entire system,and there is an urgent need to ensure the security of all industrial control protocols.The network protocol fuzzing plays an important role in ensuring the security and reliability of ICS.Traditional fuzzing methods can improve the security testing of industrial control protocols,and many of which have practical applications.However,most traditional fuzzing methods rely heavily on specifications of industrial control protocols,making the test process costly,time-consuming,cumbersome and boring.If the norm does not exist,the task is difficult to carry out.This paper proposes an intelligent and automatic protocol fuzzing method based on pointer-generation networks(PGN),and gives a series of performance indicators.On the basis of this method,an intelligent and automatic fuzzing framework based on PGNFuzz for application is designed,which can be used for various industrial control protocols.Several typical industrial control protocols such as Modbus and EtherCAT are used to test the validity and efficiency of our framework.Experiment results show that our method is superior to other general purpose fuzzers(GPF) and other deep learning based fuzzing methods in terms of convenience,effectiveness and efficiency.

Fish viscera are one of the main by-products of fish processing, and often considered a low value resource, so they are mostly discarded. Fish viscera contain high levels of protein, and fish protein hydrolysates (FPH) have functional activities such as antioxidant, hypoglycemic, anti-inflammatory, and blood pressure reduction, and can be used as a potential functional ingredient and food additive. This paper reviews the research status of the preparation process and physiological activity of the hydrolysates of fish viscera protein in order to provide reference for the deep processing and utilization of fish viscera.

Taste perception is an important factor in determining people's food intake. Understanding the relationship between taste sensitivity and food consumption behavior is one of the most innovative strategies for solving health problems caused by diet, and measuring the taste sensitivity of human subjects is the key to establish this relationship. In this paper, from the aspects of working principle, operation process and application of taste sensitivity determination, the methods of measuring human taste sensitivity at home and abroad are summarized, including psychophysical method, biopotential method, bacterial papilla counting method and genotyping method. Psychophysical measurement method is simple to operate and easy to implement, but subjective and error are large; biopotential measurement method reduces subjective errors, but the subjects need to remain relatively static during the measurement process, otherwise it will affect the stability of the electrode; fungal papilla counting method and genotyping method need to be carried out in conjunction with other methods. In addition, the genotyping method requires high technical content and cost. Through the analysis and evaluation of the above methods, it provides a theoretical basis and guidance for selecting different taste sensitivity determination methods.

Objective To analyze the expression of SIRT5 in pan-cancer and its relationship with prognosis and to explore the mechanism of SIRT5 regulating breast cancer proliferation through aldehyde dehydrogenase 5 family member A1(ALDH5A1). Methods cBioPortal,TNMplot,GEPIA and The Kaplan-Meier Plotter were used to analyze the differential expression of SIRT5 in a variety of tumors and its correlation with prognosis. The interacting proteins co-precipitated with the SIRT5 were analyzed by mass spectrometry. Pathway enrichment was performed for the interaction proteome, and for the combined analysis of the interaction proteome and the acylation proteome. Finally, the ALDH5A1 was focused. Then, the interaction between SIRT5 and ALDH5A1 was determined by an in vivo and in vitro immunoprecipitation(IP).SIRT5 was over-expressed or knocked down to detect acylation level and enzyme activity of ALDH5A1. Finally, the effects of SIRT5 and ALDH5A1 on breast cancer proliferation were determined by cell proliferation and cloning experiments. Results SIRT5 was highly expressed in a variety of tumors such as breast cancer and was positively correlated with poor prognosis (P＜0.05). There were multiple overlaps between SIRT5 interacting proteins and acylomics and the overlapped proteins were mainly enriched in metabolic pathways such as amino acid metabolism. SIRT5 directly interacted with ALDH5A1. SIRT5 could enhance the enzyme activity of ALDH5A1 by inducing the desuccinylation of ALDH5A1, thus promoting the proliferation of breast cancer cells (P＜0.05). Conclusions The function of SIRT5 in tumors may be specific to a heterogeneous environment and it can play a tumor-promoting role through ALDH5A1 in breast cancer. The results reported here may provide a theoretical basis for subsequent clinical targeted therapy.

BackgroundTwo X-ray diffractometers manufactured by HUBER company are installed at BL02U2 beamline of Shanghai Synchrotron Radiation Facility (SSRF).PurposeThis study aims to develop a new grazing incidence diffractometer installed between the two HUBER diffractometers to further satisfy the needs of users for grazing incidence diffraction experimental methods.MethodsThe overall scheme of the grazing incidence diffractometer was introduced, followed by detail discussion on several important modules such as high-precision, high-load and large-stroke linear stage, three-dimensional adjustment platform for a detector, sample stage system, and the control system. A compatible operation of the three diffractometers was realized, and the MoS2 sample was taken as an example to obtain a typical experimental result of the grazing incidence diffractometer.ResultsThe grazing incidence X-ray diffractometer has been in operation for more than two years. The X-ray energy range of the diffractometer is 4.8~28 keV. The temporal resolution of the detector is 50 ms, and the maximum detection angle is 52°. Experimental results of MoS2 sample shown that the nanosheets are more likely to accumulate on the surface of silicon wafers along the (001) crystal plane.ConclusionsThe grazing incidence X-ray diffractometer developed in this study improves the experimental conditions for grazing incidence diffraction and expands the experimental platform for material surface science research at SSRF.

Objective To investigate whether depression is a potential risk factor for falls in the elderly in China. Methods Data were collected from the Subcohort of Rugao Longevity and Aging Study. Depression in the elderly was assessed by the GDS-15(Geriatric Depression Scale), and the occurrence of falls in the subjects at baseline in 2014 and the second follow-up in 2017 were collected and recorded. According to the depression status, subjects were divided into depression group and normal group, and the general information and occurrence of falls were compared between the two groups. Logistic regression was used to analyze whether depression increased the risk of falls in older adults. Results In the cross-sectional study of 1 548 subjects, the incidence of falls was 8.3%. The proportion of subjects in the “fall” group was higher in older age, lower education level and cognitive impairment. Compared with the normal group, the depressed group had a higher proportion of women, farmers, less education, unmarried, non-smokers, non-drinkers and cognitively disabled people. After adjusting for confounders, depression was associated with an increased risk of falls at baseline and 3 years later in older adults (P＜ 0.05). Conclusions Depression is a potential risk factor for falls among the elderly in the Chinese community.

Objective To investigate the expression of immune-related molecules and the infiltration of immune cells from mouse breast cancer stem cells (BCSCs). Methods Mouse BCSCs of 4T1 and 4T07 were enriched by spheroid culturing; the expression of immune checkpoint-and antigen presentation-associated genes in BCSCs was detected by RT-qPCR; the proportion of various types of immune cells in spleen or tumor tissue of orthotopic tumor model mouse was detected by flow cytometry. Results The mouse BCSCs 4T1 and 4T07 were successfully enriched by spheroid culturing; the expression of immune checkpoints-and antigen presentation-associated genes were significantly different as compared with the adherent cancer cells; the proportion of both CD4+ and CD8+ T cell increased. However, the proportion of macrophage (CD11b+/F480+) was decreased in tumors formed by spheroid cells as compared with that in the tumors formed by adherent cells. Conclusions The expression of immune checkpoint-and antigen presentation-associated genes in BCSCs were significantly different and the infiltration of T cells increased in tumors formed by BCSCs.

Objective To construct a mouse-derived tumor organoid that can retain various types of immune cells in the immune microenvironment without artificial reconstruction. Methods The mouse-derived tumor organoids were cultured and constructed by air-liquid interface method. The histological morphology of the tumor organoids was analyzed by hematoxylin and eosin(HE). The proportion of various types of immune cells in the tumor organoids was analyzed by flow cytometry. The interleukin-2 (IL-2) was used to maintain the number of T lymphocytes in tumor organoids. Results The tumor organoids from three tumor types of mouse CT26 colon cancer, Lewis lung cancer and MC38 colon cancer all retained the histomorphology of the original tumor. Compared with mouse CT26 colon cancer tumor tissues, the proportion of CD4+T cells, CD8+ T cells and B cells in tumor organoids didn't show significant change and the proportion of macrophages decreased from 66.7% to 44.3%. The proportion of dendritic cells decreased from 66.5% to 7.25%. Compared with mouse Lewis lung cancer tumor tissue, the proportion of CD4+T cells, macrophages, dendritic cells and B cells in tumor organoids remained unchanged and the proportion of CD8+ T cells decreased from 5.6% to 1.95%. Compared with mouse MC38 colon cancer tumor tissue, the proportion of CD4+T cells, CD8+ T cells and B cells in tumor organoids remained unchanged, the proportion of macrophages decreased from 33.5% to 17%, and the proportion of dendritic cells decreased from 46.8% to 1.2%. IL-2 could increase the tumor-infiltrating T lymphocytes in tumor organoids derived from three tumor types. Conclusions Mouse tumor organoids retain the histological morphology of the original tumor and the various types of immune cells are retained in a certain extent. IL-2 can increase the quantity of T lymphocytes.

Image-based 3D reconstruction is widely used in practice due to less hardware constraints,lower cost and higher flexibility.Especially for the problems of sparseness and uneven density of the three-dimensional point cloud data generated by the image due to the occlusion between various parts of the object,it has always been a difficulty and hot issue to deal with.In this paper,a mask-based sparse point cloud filtering algorithm is proposed.Firstly,the bounding box of the point cloud is calculated and the grid is adaptively divided according to the sparseness of the point cloud.Secondly,Depth-first search is used to recursively find all customized connected domains composed of grids generated at the first step.Then adaptively calculating the threshold based on the quantized importance index,selecting the connected domains that should be retained based on the adaptive threshold,and defining the set of all retained connected domains as a mask,which is used to describe the global spatial topology information of the sparse point cloud.Finally,points covered by the mask are retained while points of the uncovered area are removed,so as to filter the outliers.This method can handle the point cloud data generated by occlusion and with great differences in spatial density.It can effectively remove outliers in the original three-dimensional point cloud data,while maintaining the detailed information of the point cloud.

This paper performed a retrospective analysis of 19 patients diagnosed with pathologically-verified WHO Ⅱ-Ⅲ grade glioma with T2/FLAIR mismatch sign. We extracted the overall characteristics of the tumor area and the image parameters of the mismatch regions from the patients' imaging data for quantitative analysis. Afterward, we investigated how T2/FLAIR mismatch sign affected the diagnostic efficacy for isocitrate dehydrogenase (IDH)-mutant and 1p/19q non-codeleted (IDHMUT/1p/19q+) lower-grade gliomas (LGG). This study showed that the overall and partial T2/FLAIR mismatch sign can be used as an imaging marker to predict IDHMUT/1p/19q+ LGG. The overall imaging characteristics of the tumor area combined with the quantitative parameters of the mismatch regions can improve the diagnostic efficacy for IDHMUT/1p/19q+ LGG.

In the scenarios of traffic diagnostic analysis and prediction in optical network based on deep learning, the work of traffic data collection and storage for optical link is limited due to security and other reasons. Aiming at the problem that the amount of traffic data is too small to support deep learning training, this paper proposes an optical network traffic data synthesis algorithm based on topology link recognition. The core idea is to combine the conditional generation model based on optical network topology and the data synthesis model based on optical network traffic in the framework of generative adversarial networks. The traffic data of the given optical link is synthesized in a self-supervised way. The simulation results show that the auto-correlation coefficients of the traffic data synthesized by the proposed algorithm is close to the real data, and the accuracy of the traffic prediction model based on fully connected neural network is more than 95%.

Query-by-Example is a popular keyword detection method in the absence of speech resources.It can build a keyword query system with excellent performance when there are few labeled voice resources and a lack of pronunciation dictionaries.In recent years,neural acoustic word embeddings has become a commonly used Query-by-Example method.In this paper,we propose to use wav2vec pre-training to optimize the neural acoustic word embeddings system,which is using bidirectional long short-term memory.On the data set extracted in SwitchBoard,the features extracted by the wav2vec model are directly used to replace the Mel frequency cepstral coefficient features,which relatively increases the system's average precision rate by 11.1% and precision recall break-even point by 10.0%.Subsequently,we tried some methods to fuse the wav2vec feature and Mel frequency cepstral coefficient feature to extract the embedding vector.The average precision rate and precision recall break-even point of the fusion method is a relative increase of 5.3% and 2.5% compared to the method using only wav2vec.

Objective: To compare the application value of magnetic resonance whole body diffusion weighted ima-ging(MR WB-DWI) combined with FS-T2WI sequence and PET/CT in detection of disease lesion and staging in newly dia-gnosed lymphoma. Methods: A total of 25 patients with newly diagnosed lymphoma and without a history of treatment for lymphoma admitted to Department of Hematology in Shanghai Ruijin Hospital from May 2014 to September 2020 were retrospectively analyzed. All the patients were histologically confirmed, including 24 cases of non-Hodgkin lymphoma and 1case of Hodgkin lymphoma. MR WB-DWI with FS-T2WI and 18F-FDG PET/CT were performed and coincidence of results between the two techniques in lesion detection and disease staging were compared. The clinical criterion was taken as the gold standard (comprehensive analysis of clinical, pathological, imaging, bone marrow puncture and 6-month follow-up results, referring to Ann-Arbor staging method). Results: Results of WB-DWI with FS-T2WI in 466 node regions out of 500 areas were congruen with those of PET/CT (K=0.807, P>0.05), there were no significant difference between two techniques in detection of intranodal lesions. The two imaging techniques agreed on 444 organs out of 450 organs analyzed (K=0.857, P>0.05). The stages based on WB-DWI with FS-T2WI was concordant with those of PET/CT in 20 patients out of 25 patients (K=0.731, P>0.05). Compared with clinical stage, PET/CT underestimated disease stage in 3 cases and WB-DWI combined with FS-T2WI underestimated disease in 2 cases. Conclusions: WB-DWI combined FS-T2WI sequence have high consistency with 18F-FDG PET/CT in lesions detection and disease staging in newly diagnosed lymphoma, and could serve as a suppliment of PET/CT.

With the vigorous development of network technology, optical networks are developing in the direction of ultra-highspeed and large-capacity. Since the structure of the optical network is becoming more complex.the optical signal will inevitably suffer various impairments in the optical network. In optical communication equipment, the most important parameter of the physical layer is the Optical Signal-to-Noise Ratio (OSNR). Its value directly determines whether the service can operate normally. Once the requirements are not met, it will cause transmission errors or failures, reducing service quality, and transmission consumption. This paper proposes an accurate and efficient OSNR prediction method for optical communication nodes. By combining analytic prior knowledge methods and deep learning-based posterior knowledge methods, an optical communication node OSNR based on hybrid machine learning algorithms are proposed. The prediction method uses prior knowledge to reduce the training cost of neural networks and provides high-accuracy OSNR predictions. The result shows that the method proposed in this paper can provide high-accuracy machine learning models under more demanding conditions.

The stem cell products has been transforming from research into drug therapy, which will benefit from traditional pharmaceutical ideas. Taking mesenchymal stem cells(MSCs) products as an example, this paper discusses the problems restricting the development of stem cell products from the perspectives of various pharmaceutical disciplines, such as medicinal chemistry, pharmaceutics, pharmaceutical analysis and pharmacokinetics, so as to provide a new strategy and pathway for the development of stem cell products in the future.

Cardiac-specific miRNAs, such as miR-1, miR-133, miR499 and miR208, are widely involved in cardiogenesis, physiology and pathology of heart. Cardiac-specific miRNAs are not only involved in cardiomyocyte differentiation in early cardiogenic stages and cardiomyocyte proliferation in the late cardiogenic stages, but also in cell damage or protection, fibrosis, and ventricular remodeling in myocardial infarction (MI) after birth. Meanwhile, cardiac-specific miRNAs can mobilize bone marrow stem cells into the peripheral blood, and promote heart repair and regeneration. In addition, circulating level of cardiac-specific miRNAs are significantly elevated after MI, which makes them to be a promising diagnostic marker for early diagnosis of acute MI.

As the optical network structure becomes larger and more complex, optical network faults are more likely to occur. After a network fault occurs, due to the derivative characteristics of network alarms, the root cause alarms will generate multiple derivative alarms. Therefore, after network faults occur, the network management system will receive alarm storms. Due to the complex relationship between faults and alarms, the difficulty of locating network faults, especially multiple faults, has also risen sharply. In response to this problem, the knowledge graph technology that is good at managing massive amounts of information and revealing the characteristics of data is introduced into optical networks. The alarm knowledge graph contains rich relationships between alarms, which can be completed by combining Graph Neural Network (GNN) technology. The knowledge-guided automatic reasoning of the root cause of network faults is in line with the fault location ideas of the operation and maintenance personnel in the operation and maintenance process. Further, the network topology information is added in the fault location process, and the knowledge dimension of the knowledge graph is improved. The limitation of the single-fault scenario is lifted, and a high accuracy rate is obtained in the multi-fault location scenario.

The microstructures and mechanical properties of Inconel 718 alloy were analyzed by using 982 ℃ water cooled solid solution bar after repeated solution and re-aging treatment, and compared with direct aging treatment.The effects of repeated solution treatment temperatures ranging from 941 to 1010 ℃ on microstructures and mechanical properties of the alloy were systematically studied. The results show that with the increase of repeated solution temperature, the content of γ′′ phase / δ phase gradually increases / decreases with no obvious change in grain size, leading to an evident improvement on room-temperature hardness, high-temperature tensile strength and stress-rupture life of the alloy. The maximum values of the tensile elongation and the stress rupture ductility are reached at the repeated solution temperature of 982 ℃. As compared to the direct aging treatment condition, there is no apparent change in microstructure and mechanical properties of the alloy aged after the repeated solution treatment at 982℃. On the contrary to the higher repeated solution temperature, the lower repeated temperature produces unfavorable effect on the mechanical properties.

The central-northern segment of the Longmen Mountains is located in the transfer zone, for which the structural characteristics are little studied. Based on the reprocessed two-dimensional seismic data, this work used methods such as field geological investigation, drilling analysis and structural interpretation to comprehensively study the structural characteristics in the central-northern segment of the Longmen Mountains. The thick belt is characterized by deep and ductile deformation and shows the combination styles of a series of tight anticlines and synclines. The transition belt I developed many imbricate faults which cut to the ground surface. The main faults in the transition belt I derived many secondary gently dipping faults in the footwall, which controlled the development of the relative fault-propagation folds. The transition belt Ⅱ is a buried structure that includes the No.1 fault. The intense imbricate thrust structures occurred in its hanging wall and the autochthonous structure with weak fold deformation developed in its footwall. This study provides new insight that the high-angle thrust faults commonly derive secondary gently dipping faults in the footwall, and both of them formed the falling-γ type of the structure style. According to the analysis of the structure characteristics and mechanism origin, it is suggested that the composite structure styles combining the imbricate and falling-γ type are the basic structure styles in the study area, which is controlled by the multiple-decollement deformation from the deep layer to the shallow layer as well as from the trailing edge to the leading edge.

Objective To investigate the effect of nicotinate-curcumin(NC) on the LPS-induced secretion of cytokines by human umbilical vein endothelial cell (HUVECs) and its mechanism. Methods HUVECs were incubated with different concentrations of NC for 24 h. Western blot was used to detect the phosphorylation of AMPK. After silencing the expression of AMPK with siRNA, the potential outcomes on the phosphorylation of NF-kappa B p65, the expression of adhesion molecules, the secretion of TNF-alpha and MCP-1 in the supernatant of LPS-induced cells, and the expression of endoplasmic reticulum stress markers IRE-1, eIF2α and CHOP were observed. Results The phosphorylation of AMPK was significantly increased and p65 phosphorylation was alleviated after HUVECs treatment with the concentration of 10~20 mmol/L NC for 24 h (P＜0.05). After silencing of AMPK, the inhibition effect of NC on NF-κB was significantly reduced(P＜0.05). At the same time, the expressions of ICAM-1, VCAM-1 and E-selectin, and the adhesion of THP-1 cells to HUVECs, content of TNF-α and MCP-1 in supernatants were significantly reduced after NC treatment (P＜0.05). After siRNA silenced AMPK, the above effects were all inhibited(P＜0.05). NC down-regulated the expression of endoplasmic reticulum stress markers IRE-1, eIF2α and CHOP induced by LPS. The inhibitory effect of curcumin on these molecules was significantly reduced by interfering with the expression of AMPK (P＜0.05). Conclusions NC inhibits LPS-induced expression, secretion of adhesion molecules and cytokines in HUVECs, and also inhibits endoplasmic reticulum stress. The mechanism is potentially related to the activation of AMPK.

Polyvinyl chloride (PVC) resin is hard and brittle. Adding fly ash (FA) will increase the hardness of PVC composites and deteriorate the processing plasticity, thus limiting the application range of PVC/FA composites. Dioctyl terephthalate (DOTP) and tris(2-hydroxyethyl) isocyanuric acid (THEIC) were used to improve the mechanical properties of PVC/FA composites. The effects of the ratio of DOTP and THEIC on the thermal stability, mechanical properties and electrical properties of PVC/FA cable composites were investigated. The results show that the combination of DOTP and THEIC can improve the thermal stability and mechanical properties of PVC/FA cable composites. When adding 29 phr DOTP and 1 phr THEIC at the same time, the elongation at break of PVC/FA2 composite is 107.98%. Compared with the composite without plasticizer, the elongation at break of PVC/FA2 is increased by 105.31%. The thermal decomposition temperature in the first stage and the second stage of PVC/FA2 is increased by 11.1 °C and 6.0 °C respectively, and the processability of the composite is significantly improved. [ABSTRACT FROM AUTHOR]

The enhanced electrochemical performance of the lithium-rich solid solution Li1.2[Co0.13Ni0.13Mn0.54]O2 (LMNCO) cathode was enhanced by phosphorus incorporation. The various phosphorus contents were introduced by adding NH4H2PO4 into the raw materials. The pristine sample and the sulfur incorporated samples were characterized by X-ray diffraction(XRD), high resolution transmission electron microscopy(HRTEM), electrochemical impedance spectroscopy(EIS). Electrochemical performance was assessed by measuring parameters such as charge and discharge capacity, rate capability in lithium ion cells. The results show that the LMNCOP-03 material has the best initial discharge capacity of 280 mAh·g-1. Moreover, it has about 212.2 mAh·g-1 and 170.6 mAh·g-1 at 1.0 C and 3.0 C rate, respectively. The LMNCOP-03 material shows an improved rate performance attributed to the enhanced electrical conductivity and lithium ion diffusion, which is proved by EIS tests.

Interpreting magnetic resonance imaging (MRI) data by radiologists is time consuming and demands special expertise. Diagnosis of prostate cancer (PCa) with deep learning can also be time consuming and data storage consuming. This work presents an automated method for PCa detection based on cascaded convolutional neural network (CNN), including pre-network and post-network. The pre-network is based on a Faster-RCNN and trained with prostate images in order to separate the prostate from nearby tissues; the ResNet-based post-network is for PCa diagnosis, which is connected by bottlenecks and improved by applying batch normalization (BN) and global average pooling (GAP). The experimental results demonstrated that the cascaded CNN proposed had a good classification results on the in-house datasets, with less training time and computation resources.

Objective To investigate the metastasis of non-sentinel lymph node (NSLN) in breast cancer patients with 1~2 positive axillary sentinel lymph nodes (SLN) and the related risk factors. Methods Clinicopathologic parameters of 383 breast cancer patients with 1~2 positive SLNs admitted in our hospital from 2016 to 2018 were collected and retrospectively studied. Univariate and multivariate analysis were used to explore the related predictors of NSLN metastasis. Results In the enrolled 383 patients, only 149 (38.9%) were observed with NSLN metastasis. Univariate analysis showed ultrasound axillary lymph node (ALN) status (P < 0.001), number of positive SLN (P=0.007), number of negative SLN (P < 0.001), number of SLN dissected (P < 0.001), metastatic rate of SLN (P < 0.001) and lymph-vascular invasion (LVI, P=0.003) were related with NSLN metastasis. Multivariate logistic regressive analysis indicated that ultrasound ALN status (P=0.001), number of negative SLN (P=0.019), metastatic rate of SLN (P=0.037), LVI (P=0.039) and HER2 over-expression (P=0.026) were the independent predictive factors of NSLN metastasis. Conclusion Ultrasound ALN status, number of negative SLN, metastatic rate of SLN, LVI and HER2 over-expression can be used as the independent predictive factors of NSLN metastasis. Attention should be paid to the clinicopathological characteristics when decision of avoiding axillary lymph node dissection in breast cancer patients with 1~2 positive SLNs.

In this paper, through the secondary development of ProCAST&CAFE software, the dynamic boundary conditions of solidification process were established, the temperature field and solid fraction in the directional solidification process of low nickel austenitic stainless steel were simulated, and the effect of the pull rate on solidification microstructure was discussed. The results shows that the withdrawal rate is in the range of 15~200 μm/s, as the solidification speed increases, the isotherm becomes dense, gummy zone narrowing. And as the solidification rate increases, the primary dendrite arm gradually refines and the secondary dendrite arm becomes dense and coarse. In addition, as the withdrawal rate increases in the range of 15 to 200 μm/s, the lateral heat dissipation of the edge of the casting is gradually smaller than that of the central longitudinal heat dissipation, and the axial deviation of the dendrites is reduced from 27.66 ° to 25.964 °. At the same time, the comparative analysis simulation results are in good agreement with the experimental results, and the simulation calculation process is more reasonable.

Taking GH4169 alloy large-size bar as research object, combined with the manufacturing process of the bar, the stress rupture properties of the specimens with different grain sizes were analyzed by means of OM, FE-SEM, EBSD and TEM. The results show that under the high temperature and stress of the long-lasting test, various grain size samples exhibit different stress rupture properties and grain orientation evolution. When the grain size is small, some orientation of〈101〉obviously rotates to 〈001〉or 〈111〉orientation where deformation and fracture occur. Besides, the coordination of macroscopic deformation of fine grain is better. These promote the effective release of stress concentration and then better plasticity. But the diffusion creep caused by more grain boundaries in the fine grain sample is unfavorable to the high temperature strength and cracks are prone to nucleate and expand at the grain boundary adjacent to the hard orientation of 〈111〉, thus the rupture life is reduced. In addition, the deformation of the fine grain sample is larger, mainly concentrated at grain boundaries, and the number fraction of large angle misorientation is more, which is easy to crack and reduce the life.

In order to balance the linear output of the exoskeleton power and the safety in the wearing process, a wearable flexible knee joint exoskeleton with two working modes of power assist and buffering is designed. Firstly, the parameter calculation and structural design of the knee bumper and whole machine model of the exoskeleton are carried out. Then, the dynamics analysis of the joint is carried out and the theoretical moment of the joint is calculated by Matlab. Finally, the calculated parameters and theoretical moments are substituted into Adams to simulate the exoskeleton under the two working modes. By comparing the simulation results with the human motion standard data, it is proved that the exoskeleton assist mode can basically meet the wearer's normal walking needs, and the buffer mode can buffer the rigid impact under sudden conditions. An important theoretical basis for the subsequent system control and prototype manufacturing is provided.

In order to investigate the influence of Linglong cementitious material on the consolidation of tailings under different conditions,a series of backfill blocks at different ratios,different densities and different curing ages are designed with ordinary Portland cement control and their uniaxial compressive strength is measured through strength test.Then the phase composition and the micro-morphology of the tailings backfill are discussed by such measuring and testing techniques as XRD and SEM.The results show that the hydration reaction of the cementitious material produces ettringite and C-S-H gel,and promotes the consolidation of the tailings backfill;the age and the ratio of cementitious material to tailings will affect the development of the content and morphology of ettringite and C-S-H gel in the hydration products,and the content of hydration products will increase with the increase of age and the ratio of cementitious material to tailings.The content of the products increases and overlaps to form a dense network structure,which is macroscopically expressed as an increase in strength;the mass concentration affects the pores in the test block,thereby affecting the strength.

Under the background of vigorously developing smart grids, the scale of power optical communication networks supporting power grid operation is becoming larger and larger, and the services carried are more diversified. However, the service routing planning of the power communication network is mainly based on the shortest path algorithm, which leads to the imbalance of the business importance distribution of the power communication networks. Therefore, the local risk of the network can be high and the overall health of the network is low. Aiming at the shortcomings of traditional routing algorithms, this paper proposes a route algorithm that uses deep reinforcement learning technology to balance the risk of network traffic, which also comprehensively considers the traditional constraints such as optical transmission constraints and link residual capacity. The algorithm considers the distribution of service importance, link capacity, and link optical signal-to-noise ratio to achieve risk equalization of power communication networks. We have carried out an experiment in a provincial power communication subnet. The result shows that the method can effectively reduce the risk balance of the power optical communication networks and provide a strong guarantee for the safe operation.