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This article introduces readers to the articles presented in this special issue of "Tsing Hua Journal of Chinese Studies" devoted to the history of modern Chinese calligraphy, much of which is seen as departing from traditional styles. The articles were chosen among many presented at a conference, "Beyond Pen and Ink: International Research Conference on Chinese Calligraphy Outside of Historical Boundaries," sponsored by National Taiwan Normal University's Institute for Research on Art History, in Taibei, Taiwan, on November 1-2, 2008.

miR plays an important biological role in skeletal development and metabolism． It regulates bone cell growth， differentiation，and functional expression． In the normal body，the signal pathway of bone metabolism is of great significance to the maintenance of normal biological function of the bone． miR regulates osteoblast /osteoblast metabolism through various signal pathways related to bone metabolism，which is beneficial to the balance of the body． If the of miR expression is imbalance，the related signal pathway is activated，leading to the corresponding bone metabolic diseases such as osteoporosis． Signal pathway is a important way of regulating bone metabolism． There are certain connections between different signal pathways． However， mechanism related to signal pathway is unclear and the related research is few． The mechanism of miR related signal pathways of precise control of bone metabolism has been gradually elucidated with the development of epigenetics． miR is closely related to a variety of osteoporosis signal pathways． It has become a potential detection markers and a therapeutic target． It is of great significance of the study the mechanism of miR-involved regulation of bone metabolism and related signaling pathways，and the prevention，diagnosis，and treatment of osteoporosis． This paper summarizes the research of miR in bone metabolism related signal pathway in osteoporosis in recent years from three aspects． [ABSTRACT FROM AUTHOR]