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Advanced information technologies and increasingly convenient transportation links have drawn countries forward into the current era of globalization, while growing transnational migration has encouraged multicultural trends. The difficulties new immigrants have in adapting to their adopted culture is an issue to which healthcare must be sensitive and responsive. Information on approaches to cross-cultural healthcare is sparse in the Taiwan literature. In this paper, the author reviews relevant domestic and overseas articles to assess historical and government policy trends as well as cross-cultural care competency development. As different ethnic populations increase, each should be provided with proper health education supported by medical volunteers from their own ethnicities. In terms of policy, healthcare personnel should understand their own culture and develop sensitivity to the needs and concerns of others. As part of their training, healthcare staff should gain a second language competency in order to enhance cultural literacy and enhance cross-cultural sensitivity and overall sensitivity within the healthcare system to the needs of the global community.