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Introduction: Pain management is an integral part of neonatal care. Exposure to pain negatively affects child development with short- and long-term effects, such as persistent and chronic pain, as well as changes in neurobehavioral responses to future painful episodes. The administration of sweet solutions is increasingly used in clinical practice as an established non-pharmacological method. Purpose: To determine the analgesic effect of Sol.Glucose 25% on the reduction of neonatal pain due to heel pricking. Material and methods: Healthy full-term newborns with an average age of 72-84 hours were studied, divided into two groups: non-anesthetised /n= 67/ and anesthetised with Sol. Glucose 25% /n=40/. The child’s reaction to pain is recorded by video surveillance. Its severity was assessed using the scales: the multimodal - Neonatal Infant Pain Scale (NIPS) and the unimodal - Neonatal Facial Coding System (NFCS) 30 sec. before, at the30th-sec. and the 5th min after the painful stimulus caused by the heel prick. Heart rate, transcutaneous saturation, respiratory rate and blood pressure were examined at the same intervals with a Biocare iM/2014 monitor. Physiological markers of pain were monitored in the 12-24 hour interval following heel prick. Descriptive analysis is used to process the results. Results: Before the procedure, the total score according to NIPS and NFCS did not differ significantly between the groups. At the 30th sec. those receiving Sol.Glucose 25% have a higher score than the control group as assessed on both scales.A significant result (p=0.034) was reported only according to NIPS. At the 5th minute, the analgesic effect of Sol.Glucose 25% was confirmed (p=0.016), when applying the multimodal scale - NIPS. When monitoring the physiological indicators, we registered a statistical difference immediately after taking Sol.Glucosae 25% before the procedure - slower breathing (p=0.001), lower transcutaneous oxygen saturation (p=0.012), higher systolic (p=0.005) and diastolic blood pressure (p=0.033). At the 30th sec. a significantly higher heart rate was found in those anesthetised with glucose solution (p=0.023), and on the 5th minute after the procedure, we reported significant differences in two indicators: breathing - slower (p=0.012) and systolic pressure - higher (p=0.020), but they are within physiological norms. In both groups, the oxygen saturation did not reach 95% at the 5th min, but was above 90% and approaching the baseline. Conclusion: Sol.Glucosae 25% has an analgesic effect that allows its application to control procedural pain in fullterm newborns. [ABSTRACT FROM AUTHOR]

Introduction: Management of procedural neonatal pain is important for clinical practice. In recent years, non-pharmacological methods (glucose solutions, kangaroo care, non-nutritive sucking, music therapy, etc.) have proven their capabilities. These include homeopathic agents.Their application as part of complementary medicine showed their effect and safety, which gave grounds for researching their possibilities to reduce procedural pain in newborns. Purpose: To determine the analgesic effect of Hypericum D6 on the reduction of neonatal pain due to heel stick. Material and Methods: Healthy full-term newborns with an average age of 72-84 hours were studied, divided into two groups: not anesthetised/ n= 67/ and anesthetized with Hypericum D6 /n=40/. The child‘s reaction to pain is recorded by video surveillance. Its severity was assessed using the scales: the multimodal - Neonatal Infant Pain Scale (NIPS) and the unimodal - Neonatal Facial Coding System (NFCS) 30 s before, at the 30ths and the 5th min after the painful stimulus caused by the heel stick. Heart rate, transcutaneous saturation, respiratory rate and blood pressure were examined at the same intervals with a Biocare iM/2014 monitor. Physiological markers of pain were monitored in the 12-24 hour interval following heel prick. Descriptive analysis is used to process the results. Results: Before the procedure, the total score according to NIPS and NFCS did not differ significantly between the groups. pain severity in the control group and in the anesthetized showed no differences, and those receiving Hypericum D6 had a higher score compared to the control group(p=0.034) accor- ding to NIPS. In the same interval, there was almost no difference in the severity of pain assessed by the Neonatal Facial Coding System (NFCS). On the 5th minute, an analgesic effect of Hypericum D6 was proved (p=0.001), evaluated with both scales. When following the physiological markers of pain, significant differences were registered in the heart rate on the 5th minute after the procedure (p=0.034). No statistical significance was recorded for oxygen saturation. Changes in the systolic component of blood pressure were Скала за оценка на болка Групи Преди начало на Процедурата р На 30 сек р На 5 мин р Общо NIPS Необезболени 1,79±0,18 0,858 6,73±0,11 0,034 4,46±0,26 Hypericum D6 1,73±0,32 6,98±0,03 2,28±0,36 0,001 Общо NFCS Необезболени 1,24±0,15 0,470 6,85±0,09 0,761 3,85±0,30 0,001 Hypericum D6 1,05±0,23 6,80±0,15 2,00±0,34 Таблица. 1. Обща оценка на тежестта на процедурната болка по двете скали found before the heel prick (p=0.04) at reference values in both groups. For the physiological marker - respiratory rate, a lower frequency was reported in those anesthetized with Hypericum D6 before the procedure (p=0.001) and at 30 seconds. (p=0.045). Conclusion: Hypericum D6 has an analgesic effect that allows its use to manage procedural pain in term neonates. [ABSTRACT FROM AUTHOR]