1. [Prognostic value of estrogen receptors--ERalpha and ERbeta, in patients with lung cancer].
- Author
-
Uchikov A, Dimitrov I, Hadjiev B, Prisadov G, Uchikova E, Ganchevska P, and Uzunova V
- Subjects
- Adult, Aged, Carcinoma, Non-Small-Cell Lung pathology, Estrogen Receptor alpha metabolism, Estrogen Receptor beta metabolism, Female, Humans, Immunohistochemistry, Lung metabolism, Lung surgery, Lung Neoplasms pathology, Male, Middle Aged, Prognosis, Survival Analysis, Carcinoma, Non-Small-Cell Lung diagnosis, Carcinoma, Non-Small-Cell Lung surgery, Estrogen Receptor alpha analysis, Estrogen Receptor beta analysis, Lung pathology, Lung Neoplasms diagnosis, Lung Neoplasms surgery
- Abstract
Summary: There are over 150 prognostic factors in lung cancer, which allow to predict the outcome of the disease.Many molecular factors are known to have independent prognostic significance. At present these factors are not routinely used in the clinical practice, but they may play an important role in the future for precise individual prognosis., Material and Methods: The study included 122 patients with non-small cell lung cancer.Using immunohistochemistry we examined the expression of estrogen receptors--ERalpha and Erbeta., Results: The median time of survival depending on the expression of Eralpha was 31 months, while for Erbeta was 73 months., Conclusions: Erbeta is a positive prognostic factor in patients with non-small cell lung cancer.
- Published
- 2010