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Introduction: medical staff in constant handling of cytostatics is exposed to various levels of respective drugs toxicity. The exposure route is: inhalation, intradermal and oral. Symptoms of toxic effects vary in length of exposure, type of drug, and route of exposure. Protective equipment at work with toxic substances is the basis of work, and all risks are exclusively related to non-compliance with safety procedures and insufficient preventive measures. Aim of the study: to examine the management of cytostatics safety, to determine the quality of work of the examined group of medical staff, to prove the persistence of harmful effects of cytostatics on medical staff and quality and efficiency of all nurses in the process of chemotherapy. Materials and methods: this is a retrospective, cohort, clinical-descriptive study, research was conducted at Clinic of Hematology, Clinic of Oncology, and Clinic of Tuberculosis and Lung Diseases of the Clinical Center University of Sarajevo in the period from January 1st to 31st December 2015. Data were collected on a voluntary basis and anonymously, using a questionnaire on the quality of safety in working with toxic substances. The study included 50 nurses of all professional profiles (nurses with completed secondary nursing school, senior nurses and graduate nurses), who have in the course of their work applied cytotherapy over a period of 1-20 years. Results: the study justified its research goal and proved inadequate and insufficient protection at work with toxic substances, malfunctions in the preparation and use of drugs in the work of healthcare providers, and the existence of harmful effects of cytostatics on healthcare providers, with 111 toxic effects in 39 subjects. Conclusion: the study was conducted on 50 respondents proved the existence of toxicity in cytostatic handling. Results of the study proved justification of establishing a centralized unit for preparation of cytostatic agents (CPC). [ABSTRACT FROM AUTHOR]