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With the emergence and expansion of additive manufacturing processes, especially the fused deposition modeling process, extensive research has been conducted on these processes. One important research area is strengthening the printed parts by the fused deposition modeling method. One of the main areas of research is related to the strengthening of printed parts by the fused deposition modeling method. This process enables the production of complex structures and the customization of parts. On the other hand, polylactic acid material is one of the main materials used in this process, which has been noticed over other materials due to its biocompatibility and biodegradability properties. In this research, the effect of annealing heat treatment on the compressive strength and modulus of porous samples has been investigated with the approach of using them in tissue engineering as a scaffold for bone tissue. The samples are 3D printed with wiggle, grid, and honeycomb patterns and with filling percentages of 40, 70, and maximum. In addition, the effect of two parameters, the extrusion width, and the layer height, has also been investigated. To create porous structures with interconnected porosities, the pattern of filling in each layer is rotated to a certain extent, and this causes the introduction of new porous structures that can have wide applications such as being used as scaffolds in tissue engineering. After evaluating the compressive mechanical properties of the samples, the same samples were heat treated, and then their compressive mechanical properties were also evaluated. The obtained results show that the maximum compressive strength and modulus occur in the sample with an extrusion width of 0.6 mm, layer height of 0.25 mm, wiggle filling pattern, and maximum filling percentage. The values of compressive strength and modulus for the non-heat-treated sample are equal to 84.51 MPa and 2.28 GPa respectively and for the heat-treated sample, it is equal to 105.44 MPa and 2.29 GPa respectively. [ABSTRACT FROM AUTHOR]