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Ticks infestation is the major problem of cattle and buffalo of Pakistan. Tick acts as vectors of many viral, protozoal and bacterial diseases and Crimean-Congo Haemorrhagic Fever (CCHF) is one of the most lethal in that list. During the last sixteen years, many sporadic outbreaks of CCHF in Pakistan has been reported with 24 percent case fatalities. In Punjab and Sind provinces mass tick control campaigns have been started to control the tick’s population and spread of zoonotic diseases through tick’s. In these tick control campaigns deltamethrin and ivermectin are used extensively. We highlighted that how extensive use of deltamethrin and ivermectin can adversely affect the environment and possible alternative methods for tick control. Extensive use of deltamethrin can damage the kidneys of insect eating birds and disturb the life cycle of many aquatic organisms if deltamethrin solution is mixed with water of streams. Widespread ivermectin use in domestic animals poses some serious threats to dung beetles and other coprophagic insects as almost 60-80 percent of total dose comes in feces without any metabolism in the body of animal. Decrease in dung beetles can result in decreased dung degradation.