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Weeds represent the most serious problem in wheat in Egypt. For their control, two field exper-iments were carried out during two winter seasons (2004/2005) and (2005/2006) at National Re-search Centre experimental station at Shalakan, Kalubia Governorate. Some groups of herbicides (Dirby, Harmony extra, Granstar, Ecopart, Illoxan, Topic and Arelon) as well as hand weeding and unweeded treatments were evaluated in wheat. In addition, herbicide combinations were also as-sessed. Harmony extra at 24 g / fed. provided ac-ceptable control for broad leaved weeds but failed to control completely narrow-leaved weeds. Topic at 140 g / fed. provided great control of narrow weeds (97.68% reduction in dry weight after 90 days from sowing). Mixtures of both Harmony extra +Topic at rates (18 g / fed. +105 g / fed.) were better than Harmony extra alone for weed control (99.19 % control, 90 days after sowing) and grain yield. Concerning the other herbicides, Granstar + Topic were effective in controlling both broad and narrow weeds. The efficacy of Harmony extra + Illoxan was lower (91.2% con-trol). Overall, Arelon or mixture of Harmony extra +Topic were the most effective treatments with regard to weed control and wheat growth, yield and its attributes. However, no carryover damage with all used herbicides was observed on wheat. Estimating individual amino acids in the yielded grain revealed increase in essential and nonessen-tial amino acids due to single or combined appli-cation of herbicides. Pronounced increase was recorded with Harmony extra and Topic