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2 results on '"Aromatase inhibitor"'

1. Effect of Aromatase Inhibitor ,Sage And Flaxseed on Spermatogenesis In Rat

Author

Heba jasem and Fadwa tawfeek

Subjects
estrogen, aromatase inhibitor, reproduction, sage, flaxseed, Education, Science (General), Q1-390
Abstract

The study was designed to investigate estrogen effect on testis, accessory sex glands and sex hormones in male rats from weaning age at 21 days by using aromatase inhibitor letrozole ( 1 mg ̷ kg b. w. ) orally till 90 days of age and investigate Phytoestrogens effect ( sage extract Salvia Officinalis ) (1000 mg ̷ kg b.w.) orally and flaxseed (25 gm ̷ 100 gm diet ) with diet till 90 days of age . Study groups include : Group one control. Group two treated with letrozole and caused a significant decrease in body and testis weights, sperm number (zero sperms), serum estrogen hormone and luteinizing hormone concentration, and significant increase in serum follicule stimulating hormone concentration. Group three treated with flaxseed and caused significant decrease in body and prostate weight, live sperm percentage, sperms number and significant increase in the dead sperm percentage and serum lutinizing hormone concentration. Group four treated with sage extract and caused significant decrease in the body and prostate weight, sperms number. Group five Treated with letrozole and flaxseed caused significant decrease in seminal vesicle weight, serum testosterone and follicular stimulating hormone concentration and significant increase in the sperms number, live sperm percentage. Sixth group treated with letrozole and sage extract and caused significant increase in sperms number and life sperm percentage, serum estrogen hormone concentration and significant decrease in serum testosterone hormone concentration. It was concluded that inhibition and reduction of estrogen hormone concentration in male rats by treatment with aromatase inhibitor letrozole produced negative effects by decreasing the body and testes weight, live sperm percentage, sperms count, concentration of estrogen hormone while administration of flaxseed and sage extract produced positive effects in reproductive efficiency through the increase in the percentage of live sperm, estrogen and luteinizing hormone concentrations and spermatogenesis in adult rats. We concluded from the study the important role of estrogen hormone in reproductive function of male rats which cleared by the negative effects that resulted from lowering estrogen hormone level by using aromatase inhibitor letrozole and the administration of flaxseed and sage extract improved some effects produced by estrogen hormone deficiency.

Published
2020
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2. Aromatase Inhibitor, Flax seed and Sage Effects on Adult Rats Fertility and Sexual Behavior

Author

Fadwa khalid tawfeek and Heba mohammed jasem

Subjects
aromatase, medicine.medical_specialty, medicine.drug_class, media_common.quotation_subject, male reproductive system, Fertility, Internal medicine, medicine, estrogen, Male reproductive system, Aromatase, ltrozole, lcsh:Science (General), media_common, Aromatase inhibitor, biology, SAGE, Endocrinology, sage, Sexual behavior, Estrogen, biology.protein, flax seed, lcsh:L, lcsh:Education, lcsh:Q1-390
Abstract

The current study was designed to detect estrogen role in adult male rats by giving aromatase inhibitor ( ltrozole 1 mg̷ Kg. B. W) for 60 days orally to inhibit aromatase enzyme activity and to study the effect of giving source of estrogen flax seeds (25 g ̷ 100 g diet) and aqueous extract sage (1000mg ̷ Kg. B.W.) orally. The study showed that adult male rats treated with ltrozole resulted in a significant decrease in the weight of testes, prostate , percentage of live sperms , number of sperms , number of mounting , intromission, ejaculation and in the time period from mixing with females to the first mounting , intromission and ejaculation , the time period between mount and another, intromission and another, ejaculation and another, and significant increase in the percentages of dead as well as abnormal sperms. Flax seeds treatment significantly reduced percentage of live sperms, number of sperms, number of mounting , intromission, and ejaculation, and significantly increased percentage of dead sperms compared with control group. Sage extract treatment caused a significant decrease in number of sperms, number of mounting, intromission and ejaculation , as well as a significant increase in the time period from mixing of female to the first mounting, first intromission and first ejaculation compared with control. The results showed that administration of sage extract with letrozole showed a significant increase in testis weight, percentages of live sperms and number of sperms, and asignificant decrease in dead and abnormal sperms compared with the letrozole group. Administration of flax seed with letrozole did not significantly change weight of the testis , prostate, percentage of live, dead , abnormal sperm and number of sperm compared with letrozole group. Administration of Flax seed and sage extracts to male rats treated with letrozole did not significantly change all the done tests of sex behavior. The study concluded that estrogen has an important role in the function of male reproductive system, which is shown through the negative effects of the aromatase inhibitor on the weights of the testis, prostate, live and dead and abnormal sperm, and sexual behavior. Sage extract, but not flax seed, has benefit effects on the defect induced by aromatase inhibitor letrozole both flax seed and sage do not produce positive effects on sexual behavior .

Published
2020

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