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The study was aimed to produce silver nanoparticles using catechin and Apigenin each a lone as a reducing and coverage also to investigate the anti- oxidant effects of catechin – silver nanoparticles and Apigenin silver nanoparticles on some biochemicals parameters in blood serum, Liver and kidney tissue in hydrogen peroxide – exposed rats. Scanning Electron Microscope was used to investigate the morphology and size of synthesized silver nanoparticles. (36) adults male rats were randomly and equally divided into three groups (3 rat/ group). Group (1): control group received drinking water and standard diet only, given (I) for catichin – AgNPS and (VI) for Apigenin – AgNPS. Group (2): received (%0.5H2O2) with drinking water only for 4 weeks, given (II) for catechin – Apigenin and (VII) for Apigenin - AgNPS. Group (3): received tap water and standard diet and given (50mg/kg) catechin – AgNPS, given (V) and (50mg/kg) Apigenin - AgNPS, given (X). Result showed a significant decrease (P≤0.05) in GSH level and a significant increase in MDA livel in blood serum, liver and kidney tissue of rats. The treatment with catichin – AgNPS, Apigenin - AgNPS.each a lone lead to positive effect of oxidative damage through the significant increasing (P≤0.05) in GSH level and significant decrease (P≤0.05) in MDA level in blood serum, liver and tissue of rats. [ABSTRACT FROM AUTHOR]