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The analysis of 650 cases of ischemic stroke in accordance with the TOAST criteria showed that atherothrombotic subtypes of ischemic stroke (p0.05) appeared most commonly. Based on the results of the analysis of basic clinical and paraclinical signs in the acute period of ischemic stroke, we worked out two models for the prediction of fatality by severity of atherothrombotic and cardioembolic subtypes which allowed to improve the quality of outcome. In the group of patients with more severe strokes, more favorable outcomes were found for the atherothrombotic pathogenetic variant compared to atherothrombotic stroke (p0.05). Synergetic characteristics of the developed models were shown.

Basing on the results of the analysis of the main clinical-paraclinical syndromes of ischemic stroke in its acute period, two integrative analytic-prognostic systems have been designed. These systems improve quality of disease prognosis. More accurate prognosis is achieved by the model, which shows that outcome of ischemic stroke depends both on the initial condition of the disease and on its dynamics in the acutest period. The computerized system of early prognosis of ischemic stroke allows to give a detailed prognosis of complications and outcome of the disease. The use of the computerized system of early prognosis helps to gain the reliable improvement in groups of moderately severe and severe ischemic stroke.

Basing on the results of multiple classifications of 70 clinical, paraclinical and anamnestic signs of ischemic stroke with combined cardiac symptomatology, the models predicting clinical outcome in acute period of the disease and an original scale of numerical score have been worked out. It is mathematically proved that the severity of ischemic stroke with combined cardiac symptomatology, scoring 75 and above, inevitably results in progression of fatal outcome. A group of unfavorable clinical predictors was singled out. The periods with high rate of fatal outcome within exacerbation of ischemic stroke and pathogenic types of stroke were studied. It is first-ever shown that a role of cardiac and neurological symptoms in predicting fatal outcome depends on ischemic stroke severity. A relation between the probable fatal outcome and dynamics of severity of stroke with combined cardiac symptomatology within the first 3 days of the disease was also revealed for the first time.