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Reperfusion therapy is one of the main treatment strategies of ischemic stroke. The first studies of the efficacy of thrombolytic medications started form the use of streptokinase and fibrinolysin in patients with ischemic stroke in late 50 - early 60 of the XX century in the United States, Soviet Union, and Western Europe. After the development of recombinant tissue plasminogen activator, thrombolysis became one of the main methods of reperfusion in patients with acute ischemic stroke, acute myocardial infarction, or other acute vascular thrombotic events. Later, modified variants of tissue plasminogen activator with prolonged clearance time, high fibrin-selectivity, and bolus delivery were introduced. Another group of thrombolytic agents includes derivatives of flora and fauna - external plasminogen activators, of which streptokinase, staphylokinase, and desmoteplase are most common drugs. These medications are not a structural part of the human organism, and overcoming of immunogenicity while preserving fibrinolytic activity and fibrin specificity is one of the main tasks in applying them in clinical practice.

Objective: to study the efficacy of cytoflavin in thrombolytic treatment of patients with acute ischemic stroke (IS)., Material and Methods: Fifty-five patients in the acute stage of IS were examined. The National Institutes of Health Stroke scale (NIHSS), the Rankin scale and the Barthel index of activities of daily living were used. Depending on the scheme of treatment, patients were divided into 2 groups: the first (basic) group included 29 patients who received cytoflavin immediately after thrombolytic therapy. The control group (26 patients) received basic vascular and neuroprotective treatment., Results and Conclusion: The marked reduction in the severity of neurological symptoms to the 10th day of treatment and higher probability of a successful outcome were noted in the basic group compared to the controls. There was an improvement of functional activities according to the Rankin scale and of activities of daily living assessed by the Barthel index, with scores "moderate dependence" in the basic group and "severe dependence" in the control group. The inclusion of cytoflavin in the treatment scheme of patients with acute IS increased the efficacy of treatment.

Objective: To evaluate an impact of low calorie diet therapy (LCDT) on cerebral hemodynamics, cognitive functions and quality-of-life of patients with arterial hypertension and chronic cerebral ischemia., Material and Methods: The main group consisted of 22 patients, 16 women and 6 men (mean age 54.4±2.4 years), assigned to the diet. The comparison group included 20 patients, 12 women and 8 men (mean age 55.6±1,0 years), who received standard antihypertensive treatment. The results of Doppler ultrasound of cerebral arteries, cognitive functions and quality-of-life were assessed after 6 months of treatment., Results and Conclusion: A positive effect of LCDT on the cerebral hemodynamics, cognitive functions and quality-of-life indices maintained for 6 months. The efficacy of LCDT was comparable to that of standard treatment in the comparison group.