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Several methods to promote the secretion of milk in 280 puerperants have been tested in this study. A multi-agent controlling method to promote the secretion of the milk was found. The effective control agents, such as the condition of breast, the stimulation of the secretion of milk, and the collagen soup with appropriate time and quantity, have been selected. According to the observation, the percentage of milk fed infants reached 98% in 24 hours post partum in the study group, while it only reached 5% in the control group (P < 0.01). Compared with the general regulation that the secretion of milk started on the third day post partum, and reached 200 ml on the 4 approximately 5th day, the multi-agent controlling method to promote the secretion of milk improved the time and quantity of the milk secretion. It would lay an excellent foundation for the infant growth.