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Sleep quality and psychical health were investigated with Pittsburgh Sleeping Quality Index (PSQI) and SCL-90 in 128 patients with hyperthyroidism. The results showed that: 1. The PSQI scores of the patients with ages over 35 years old were higher than that less than 35 years old (P0.05). 2. Sleep problems occurred in 87.55% of the patients. Sleep quality of 9.38% of patients were worse. The sleep quality of the female patients were better than the male (P0.05). 3. Apart from interpersonal sensitivity, paranoid ideation and psychoticism, scores of the rest were higher than the general people (P0.05). 10.2% of the patients with hyperthyroidism had psychical problems. 4. Apart from sleep time and using sleep pill, there was a high correlation between the scores of SCL-90 and PSQI (P0.05-P0.001). The results showed that sleep problems of the patients with hyperthyroidism affected their psychical health. Lower sleep quality was a main dangerous factor which affected psychical health of the patients with hyperthyroidism.

It was reported that sodium thiosulfate (STS) was contributed to antivomiting effect in 20 transarterial chemotherapic patients. The antitumor sensitivity of STS (500 micrograms/ml) adjuncting to the ADM, MMC, CDDP and other four agens (1 x PPC/ml) individually on two tumor cells studied by MTT test in vitro and no antitumor activity of adjuvant of STS were obviously obliterated (P0.05) except for CDDP clinically, to comparing the adjuncting effects of STS (iv. 30 min ahead) or metochlopramidum (im. 30 min ahead) to ADM, MMC and CDDP on HCC (40 cases), the degrees of vomiting in hepatoma patient after transcatheter arterial chemoem bolization with ADM, MMC and CDDP were statisticaly analysec. It have been proven that STS was contributed to the low incidence of vomiting and superior to metocloe pramidum, without worsening of the chemotherapy of HCC. It is worth futher studying adjuvant STS to other antitumor drugs and exploring potential application of chematherapy in cancer.

The prevention methods of the side effects of 75g glucose tolerance test were studied. The results showed that the speed of taking glucose water was 3-5 minutes; the water temperature was 20-30 degrees C; water volume of dissolving glucose was 300ml; 0.25g citric acid was added, the side effects will be avoided or reduced.

In order to make an investigation on skin ulcer induced by Mitomycin C extravasation, the preventive measures were undergone by the following ex-periment. A subcutaneous ulcerative model induced by 0.1mg Mitomycin C (MMC) extravasation in the leg of BALA/C mice was established. On the model subject, 8 pharmacologic adjuvants or physical modulation were adopted. It is preferential to choose local injection with 0.1 ml 99% dimethyl sulfoxide (DMSO), or with additional smearing DMSO on the affected skin. 10 days later, the ulcerative areas with DMSO treatment were significantly decreased in contrast with 0.1 ml 0.9% NaCI treatment (P0.001). The other preferential treatment were in turn by the injection of 0.1 ml 5% NaHCO3 (P0.001); 0.1 ml 1% procainamidi hydrochloridum (including 0.4% dexame-thasonum) (P0.001) or smearing with 0.1 ml 90% DMSO (including 10% Vit E) (P0.01). Delayed application of DMSO after MMC extravasation 30 min had been proven the limited effects on the prevention of ulcer (P0.05). Neither cooling of skin or local injection of sodium thiosulfate reduced MMC ulceration (P0.05). The mechanisms of prevention of MMC extravascular ulcer by DMSO or 5% NaHCO3 were briefly discussed.