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Objective: To know the characteristic of AEFI clusters, and provide reference for preventing and handling of AEFI clusters., Methods: The literature were collected from CNKD and WAN FANG datebases 1999-2009. 4. The related information were analysed from the qualified literatures., Results: 75 clusters from 83 literatures of 41 kinds of journal were identified. Among them, 64% occurred in rural area, 62.67% occurred at school. 10 kinds of vaccines were identified. 13 clusters of Japanese encephalitis vaccine (JEV), 12 of Bacillus Calmette-Guerin (BCG), 10 of meningococcal polysaccharide vaccine (MPV), and 10 of live attenuated measles vaccine (MV), totally accounted for 60%. Common, minor reactions accounted for 5.33%, Rare, serious reactions was 17.33%, Coincidental illnesses was 12%, Psychogenic reactions was 46.67%, practice error events was 46.67%. 4 465 cases were reported, and 95.52% of them were school students. 82.22% were psychogenic reactions and 9.14% were coincidental illnesses. Common, minor vaccine reactions were fever; rare, serious vaccine reactions mainly were anaphylaxis, which accounted for 57.14%; psychogenic reactions mainly were hysteria, which accounted for 97.14%, 57.58% of them occurred after Vaccination of JEV, MPV and MV. Practice error events mainly were local redness and swelling, induration abscess and diabrosis. Clusters occurred after BCG vaccination accounted for 71.43%., Conclusion: AEFI clusters occurred mainly in rural areas and after immunization campaigns at school. The incidence rate of common, minor vaccine reactions and rare, serious vaccine reactions were low. Psychogenic reactions and practice error events, especially after BCG vaccination, had a higher incident rate. The total occurrence of clusters and the average cases of each events were larger. It is important to improve the quality of vaccination service for preventing and handling AEFI clusters.

To evaluate the risk of sequela after serious vaccine reaction. The rare serious vaccine reactions might result in sequela, the incidence of rare serious vaccine reactions, the estimated incidence of sequela and cases reported were reviewed. Further research should be developed to provide the scientific basis for sequela control and prevention.

Objective: The study is to analyze the occurrence features of Adverse Event Following Immunization (AEFI) in China, and to evaluate the implementation of AEFI surveillance system, the safety of National Immunization Program (NIP) Vaccines and the quality of the immunization services., Methods: The AEFI data of 2007-2008 were collected through the China Information System and the Children Immunization Information System, which reported before march 25, 2009. The descriptive methodology was used in the study., Results: 32120 AEFI cases of 2007-2008 were reported, 95.02% were reported from 10 pilot provinces. The ratio of male and female was 1.41:1.77. 53% cases were < OR =1 years old and the cases were occurred more often between april to october. The first three vaccines are DPT, MPV and JREV. 65.85% happened after the 1st and 2nd dose and 75.05% within 1 d after vaccination. The estimat reported incidence of NIP vaccines were 7.99-322.77 per million doses. In the classification of AEFI cases, 79.93% cases were common, minor reactions, 14.65% were rare, serious reactions and others were <5%. Anaphylaxis, sterile abscess and vaccine reaction of BCG were the most common clinical diagnosis. 91.2% AEFI cases were cured or improved. Only 1.93% were hospitalized, among them 2/3 stayed in hospital < or = 10 d., Conclusions: Comparing with 2005-2006, the completeness and sensitivity of national AEFI surveillance system were improved greatly in 2007-2008, but it still needs to be strengthened. The NIP vaccines were significantly related to the introduced vaccines in Expanded Immunization Program. AEFIs occurrence mostly in young children, first-dose and the early period of vaccination. The pilot study showed that safety of NIP vaccines and the quality of immunization services are satisfied.