1. Dopamine and intertemporal choice in humans
- Author
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Nuria Rojo-Fite, Zheng Ye, Ludger Schöls, Thomas F. Münte, Josep Marco-Pallarés, Antoni Rodríguez-Fornells, Ulrike M. Krämer, Estela Camara, Toni Cunillera, David Cucurell, and Rebecca Schüle
- Subjects
Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Dopamine ,Cognitive Neuroscience ,Mediation ,medicine ,medicine.symptom ,Impulsivity ,Psychology ,Intertemporal choice ,Neuroscience ,Dopamine agonist ,medicine.drug - Abstract
Abstract. The dopamine (DA) system has been implicated in the mediation of cost/benefit evaluations involved in the intertemporal choices between immediate and delayed rewards. This involvement was further investigated in two studies of normal participants that had to decide between a smaller immediate and a larger delayed reward in a series of 27 decisions.In study 1 the dopamine D2/D3 receptor agonist pramipexole or placebo were administered in a double-blind cross-over protocol prior to the decisions. In study 2 the same experiment was conducted in two groups of normal participants that were homozygous for either the 7repeat or the 4 repeat variant of the exon III polymorphism of the Dopamine D4 receptor gene. Dopaminergic involvement is highlighted by the results.
- Published
- 2018
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