1. Origin of renal proximal tubular injuries by Fe(III)-nta chelate
- Author
-
Takahiro Satoh, Yuuta Ito, and Yuzo Nishida
- Subjects
Transferrin ,chemistry.chemical_element ,Electrophoresis, Capillary ,Glutathione ,Ethylenediamines ,Iron Chelating Agents ,Oxygen ,Peroxide ,General Biochemistry, Genetics and Molecular Biology ,Adduct ,Rats ,Kidney Tubules, Proximal ,chemistry.chemical_compound ,Capillary electrophoresis ,chemistry ,Polymer chemistry ,Animals ,Humans ,Chelation ,Apoproteins ,Kidney tubules - Abstract
Interaction between apo-transferrin and several iron(III) chelates has been investigated in terms of the capillary electrophoresis method. Based on the results, it has been clarified that (i) a binuclear iron(III) unit with an oxo-bridge is necessary for the facile transfer of an iron atom from the iron(III) chelate to apo-transferrin, and (ii) the renal proximal tubular injuries by Fe(III)-nitrilotriacetate (Fe-nta) should be due to the unique binuclear structure of this complex, which gives a peroxide adduct of the binuclear Fe-nta in the presence of glutathione cycle and oxygen
- Published
- 2007