1. Clastogenic Effect of Carthamus lanatus L. (Asteraceae)
- Author
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Rilka M. Taskova, Helmut Duddeck, Nedjalka Handjieva, M. Topashka-Ancheva, and Bozhanka Mikhova
- Subjects
Male ,Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie ,dimethyl sulfoxide ,plant ,Asteraceae ,Carthamus lanatus ,Mice ,chemistry.chemical_compound ,Clastogenic Effect ,animal ,comparative study ,Mice, Inbred ICR ,biology ,Traditional medicine ,mutagenic agent ,article ,female ,Institute for Cancer Research mouse ,plant extract ,Female ,analysis of variance ,water ,Carthamus ,chemistry ,solvent ,Chromosome aberration ,General Biochemistry, Genetics and Molecular Biology ,Clastogen ,ddc:570 ,Botany ,Animalia ,Animals ,Dimethyl Sulfoxide ,mouse ,methanol ,Dichloromethane ,Chromosome Aberrations ,Analysis of Variance ,Methylene Chloride ,isolation and purification ,Plant Extracts ,Dimethyl sulfoxide ,Methanol ,Mitomycin C ,Water ,Plant Components, Aerial ,biology.organism_classification ,dichloromethane ,Solvents ,chromosome aberration ,Mutagens - Abstract
The clastogenic effect of total dichloromethane, methanol and water extracts, four bioactive fractions and three individual constituents from Carthamus lanatus aerial parts were evaluated in mice by bone marrow chromosome aberration assay with mitomycin C as positive control. Significant differences in the percentage of aberrant mitosis of the extracts were observed. The dichloromethane extract exhibited a considerable clastogenic effect and the water extract a negligible one. Different types of chromosome aberrations and time-dependant effects for the active fractions and individual compounds were found.
- Published
- 2003
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