1. [Identification of chemical constituents in Yangxue Qingnao granule by UPLC-Q-TOF/MS~E].
- Author
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Yang DL, Tong L, Li XW, Li DX, and Liu WY
- Subjects
- Alkaloids analysis, Anthraquinones analysis, Benzofurans analysis, Chromatography, High Pressure Liquid, Glycosides analysis, Hydroxybenzoates analysis, Monoterpenes analysis, Quality Control, Spectrometry, Mass, Electrospray Ionization, Tandem Mass Spectrometry, Drugs, Chinese Herbal analysis
- Abstract
In order to clarify the chemical constituents in Yangxue Qingnao granule, we established a rapid ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry (UPLC-Q-TOF/MS(E)) method. According to the high resolution MS spectra data, fragmentation ion information and retention time,142 peaks were identified or tentatively presumed by comparison with reference standards data and literature reports. The herbal sources of these peaks were assigned. The results implied that phenolic acids, alkaloids, anthraquinones, phthalides, monoterpene glycosides were included in the main components of Yangxue Qingnao granule. The method is rapid for systematically elucidation of the constituents of Yangxue Qingnao granule and the results would facilitate the quality control of Yangxue Qingnao granule for safe and efficacious use.
- Published
- 2016