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Von Hippel-Lindau (VHL) disease is a multisystem disease cause by germline mutations of the VHL tumor suppressor gene. Hemangioblastomas are the most common manifestation of VHL disease and can occur in the central nervous system in up to 90% of these patients. By contrast, we found only one true case of a peripheral nervous system (PNS) hemangioblastoma in the setting of VHL. We explore the possible reasons behind the lack of PNS hemangioblastomas in VHL disease.

he radiographic characterization of intra-axial brain tumors is a critical component in the clinical management of paT tients. Magnetic resonance (MR) and computed tomography (CT) imaging are fundamental imaging techniques used in the initial diagnosis and subsequent surveillance during/after treatment. On the basis of diagnostic imaging (often after the development of symptoms/signs), surgical intervention often is performed that frequently is followed by adjuvant chemotherapy or radiation. Serial imaging, typicallyMR imaging, is used to assess the response to adjuvant therapy and to monitor for recurrence or progression. Currently, CT imaging (nonperfusion) often is reserved for acute neurologic decline that results from hemorrhage, hydrocephalus, or other mass lesions.

Mild traumatic brain injury (mTBI), including concussion, associated with contact sports and activities of daily living is increasingly recognized as a cause for disruption of cognitive functioning involving attention, executive functions, and memory. Emerging evidence indicates that traumatic axonal injury may be associated with long-term cognitive and neuropsychological disability in severe brain injury, as well as the common transient signs and symptoms linked to mTBI. Because traditional neuroimaging sequences are insensitive to the subtle white matter changes that may underlie axonopathy in mTBI, magnetic resonance (MR) diffusion tensor imaging (DTI) has been used for detection of fiber tract disruption and tracking white