7 results on '"Brokinkel, Benjamin"'
Search Results
2. Brain Invasion in Meningiomas: The Rising Importance of a Uniform Neuropathologic Assessment After the Release of the 2016 World Health Organization Classification of Central Nervous System Tumors.
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Brokinkel, Benjamin and Stummer, Walter
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MENINGIOMA , *BRAIN tumors , *NEUROLOGICAL disorders ,CENTRAL nervous system tumors - Published
- 2016
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3. Heterotopic Neuroglial Tissue in Sphenoid Ridge.
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Bruns, Ann-Katrin, Jeibmann, Astrid, Brokinkel, Benjamin, Holling, Markus, Stummer, Walter, and Ewelt, Christian
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ECTOPIC tissue , *MENINGIOMA , *SKULL , *TISSUES - Abstract
Background Extracerebral neuroglial heterotopias are rare manifestations of cerebral tissue outside the brain whose most common form is the so-called nasal glioma. In this case report we illustrate the first case of heterotopic neuroglial tissue within the bone of the skull. Case Description Our patient underwent surgery for a sphenoid ridge meningioma. Aside from the expected meningioma, histopathologic examination showed a small amount of intraosseous heterotopic neuroglial tissue. Conclusions The pathogenesis of cerebral heterotopias is diverse. Most of the midline lesions are probably residuals of former meningoencephaloceles. The pathogenesis of extracranial nonmidline lesions is more questionable. Their cause might be a former trauma, inflammatory disease, or surgery. Another option is that they represent primary neuroglial heterotopias, as it is supposed for manifestations of the lung. The coexistence of a heterotopia and a meningioma in this case is probably a coincidence. It is also debatable whether the broad tumor extension within the bone and/or the heterotopia might go back to alterations of the bone structure. [ABSTRACT FROM AUTHOR]
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- 2019
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4. Prediction of High-Grade Histology and Recurrence in Meningiomas Using Routine Preoperative Magnetic Resonance Imaging: A Systematic Review.
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Spille, Dorothee Cäcilia, Sporns, Peter B., Heß, Katharina, Stummer, Walter, and Brokinkel, Benjamin
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MAGNETIC resonance imaging , *META-analysis , *CLINICAL prediction rules , *HISTOLOGY , *POSTOPERATIVE care - Abstract
Estimating the risk of recurrence after surgery remains crucial during care of patients with meningioma. Numerous studies identified correlations of characteristics on routine preoperative magnetic resonance imaging (MRI) with postoperative recurrence or high-grade histology but showed partially inconclusive results. A systematic review of the literature was performed about findings on preoperative MRI and their correlation with high-grade histology and recurrence. Quality of the included studies was analyzed using standardized Quality Assessment of Diagnostic Accuracy Studies criteria. Among the 35 studies included, quality of the series according to the Quality Assessment of Diagnostic Accuracy Studies criteria differed widely. Remarkably, MRI variables found to be associated with high-grade histology were commonly not consistently associated with prognosis and vice versa. Correlations of the tumor size, the peritumoral edema size, and contrast-enhancement of the tumor capsule with high-grade histology were controversial. In most studies, non-skull base tumor location, cyst formation, heterogenous contrast-enhancement, an irregular tumor shape, and disruption of the tumor/brain border but not intensity of the lesion on T2-weighted images, calcifications, or bone involvement were associated with grade II/III histology. Although tumor and edema size were usually found to correlate with recurrence, heterogenous contrast enhancement, cyst formation, intensity of the tumor on T2-weighted MRI, and enhancement of the tumor capsule were mostly not related with progression. Several mostly consistent but partially inconsistent variables associated with high-grade histology or prognosis were identified. Although standardized studies are needed to provide further clarification, consideration of these findings can help to improve estimation of prognosis and can therefore improve postoperative care in patients with meningioma. [ABSTRACT FROM AUTHOR]
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- 2019
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5. Local Tumor Control and Clinical Symptoms After Gamma Knife Radiosurgery for Residual and Recurrent Vestibular Schwannomas.
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Suero Molina, Eric, van Eck, Albertus T.C.J., Sauerland, Cristina, Schipmann, Stephanie, Horstmann, Gerhard, Stummer, Walter, and Brokinkel, Benjamin
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RADIOSURGERY , *ACOUSTIC neuroma , *SCHWANNOMAS , *FACIAL nerve , *FACIAL nerve diseases , *MICROSURGERY , *KNIVES - Abstract
Background The use of Gamma Knife radiosurgery (GKRS) for recurrent or residual vestibular schwannoma (VS) after microsurgery (MS) has been investigated in several retrospective studies. The purpose of this study was to identify potential risk factors for both neurologic deterioration and tumor progression after GKRS for previously operated VSs in a prospective setting. Methods Patients who underwent GKRS for previously operated and histopathologically confirmed VS between 1998 and 2015 were prospectively followed-up. Risk factors for therapy side effects and predictors for tumor control were investigated in uni- and multivariate analyses. Results A total of 160 individuals with a median age of 55 years were included. Median tumor volume prior to GKRS was 1.40 cm3 (range, 0.06–35.80 cm3). After a median follow-up of 36 months, hearing and facial nerve function were serviceable (modified Gardner-Robertson and House-Brackmann grades I and II) in 7 (5%) and 82 (55%) patients, respectively. Deterioration to a nonserviceable facial nerve function after GKRS was found in 3% (3/89) and tended to increase with rising tumor volume (odds ratio, 1.65 per cm3; 95% confidence interval, 1.00–2.71; P = 0.051). Median tumor volume prior to GKRS was higher in patients with radiologic (P = 0.020) or clinical tumor progression (P < 0.001). Critical tumor volume prior to GKRS to predict clinical and radiologic tumor progression was 1.30 cm3 (P < 0.001) and 3.30 cm3 (P = 0.019), respectively. However, in multivariate analyses, none of the analyzed variables were found to independently predict tumor progression. Conclusions Intended submaximal resection followed by GKRS is a viable treatment for VS. Because tumor remnant size after MS is an important predictor for recurrence after adjuvant GKRS, both brainstem and cerebellar decompression and maximal safely achievable resection should remain major goals of microsurgery. [ABSTRACT FROM AUTHOR]
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- 2019
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6. Is the Simpson Grading System Applicable to Estimate the Risk of Tumor Progression After Microsurgery for Recurrent Intracranial Meningioma?
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Schipmann, Stephanie, Schwake, Michael, Sporns, Peter B., Voß, Kira Marie, Sicking, Johanna, Spille, Dorothee Cäcilia, Hess, Katharina, Paulus, Werner, Stummer, Walter, and Brokinkel, Benjamin
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MENINGIOMA , *CANCER invasiveness , *MICROSURGERY , *CANCER relapse , *SURGICAL excision - Abstract
Objective We analyzed the applicability of the Simpson grading system to estimate the risk of tumor recurrence after microsurgery for recurrent meningiomas. Methods Correlations between the Simpson grade and the extent of resection (EOR) (gross total resection [Simpson grade I and II] vs. subtotal resection [Simpson grade ≥III]) with tumor relapse after microsurgery for meningioma recurrence were investigated compared with the findings in primary diagnosed tumors. Location-specific differences were further elucidated in subgroup analyses. Results A total of 829 individuals (88% in group A) with primary diagnosed meningioma and 109 patients with first postoperative recurrence (12% in group B) who underwent surgery were included. In group A, both Simpson grade (P = 0.003) and EOR (P < 0.001) correlated strongly with recurrence. In group B, Simpson grade correlated with tumor location (P = 0.030), and the risk of subtotal resection was greater in the posterior fossa (odds ratio, 5.26; P = 0.018) and skull base (odds ratio, 6.16; P = 0.002) meningiomas. Older age at tumor relapse (hazard ratio [HR], 1.05; P = 0.001), male sex (HR, 2.19; P = 0.02), and grade 2/3 histologic findings (HR, 2.18; P = 0.02). However, neither the Simpson grade nor dichotomized EOR correlated with further tumor recurrence. The frequency of postoperative complications was similar in both groups. Conclusions Surgery for recurrent meningiomas is not generally associated with an increased risk of postoperative complications compared with resection of primary diagnosed tumors. However, the Simpson grade and EOR in recurrent meningiomas correlated poorly with further tumor relapse. The lower prognostic value of the tumor remnants left behind during microsurgery for recurrent meningiomas should be considered when operating on lesions that can be surgically challenging. Highlights • We analyzed the applicability of the Simpson grade after surgery for recurrent meningiomas. • The Simpson grade is a poor predictor of second recurrence after surgery for recurrent meningioma. • Surgery for recurrent meningioma is safe. • A retentive surgical treatment should be considered for resection of recurrent meningioma in surgical challenging locations. [ABSTRACT FROM AUTHOR]
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- 2018
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7. Brain Invasion in Meningiomas: Incidence and Correlations with Clinical Variables and Prognosis.
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Spille, Dorothee Cäcilia, Heß, Katharina, Sauerland, Cristina, Sanai, Nader, Stummer, Walter, Paulus, Werner, and Brokinkel, Benjamin
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MENINGIOMA , *CANCER invasiveness , *TUMOR grading , *DISEASE incidence , *PROGNOSIS ,CANCER histopathology ,TUMOR surgery - Abstract
Objective In meningioma, correlation of brain invasion with prognosis and clinical variables remains controversial. Methods Correlation of brain invasion with clinical and histopathologic variables was investigated in 467 patients with primary intracranial meningioma. Results Diffuse ( n = 3; 10%), clusterlike ( n = 11; 34%) or fingerlike ( n = 18; 56%) invasion was detected in 32 patients (7%). Brain invasion was more common in males than in females (13% vs. 5%; odds ratio, 2.75; 95% confidence interval, 1.29–5.89; P = 0.009) and pattern of invasion differed between genders ( P = 0.037). Brain invasion was absent in 401 benign meningiomas and present in 48% of 60 atypical ( n = 29) and 50% of 6 anaplastic ( n = 3) meningiomas ( P < 0.001) but was independent of tumor location and extent of resection. Progression occurred in 11% and was more frequent (31% vs. 15%; P = 0.036) in invasive than in noninvasive tumors, but only after gross total resection and in univariate analyses, and independent of invasion pattern. In atypical meningiomas, frequency of adjuvant irradiation was similar comparing invasive and noninvasive tumors and grading solely based on brain invasion ( n = 20; 33%), other World Health Organization (WHO) criteria ( n = 31; 52%) or a combination of both ( n = 9; 15%). Risk of recurrence was lower (hazard ratio, 0.258, 95% confidence interval, 0.09–0.734; P = 0.011) when grading exclusively based on brain invasion than when further WHO criteria were in addition present and the progression-free interval among the first was similar to benign tumors. Conclusions Brain invasion and its patterns are correlated to gender. In contrast to the current WHO classification, invasion was associated with recurrence only after gross total resection and not independent of further histopathologic criteria of atypia. [ABSTRACT FROM AUTHOR]
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- 2016
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