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41 results on '"Gontero P."'

1. Differential effect of surgical technique on intravesical recurrence after radical nephroureterectomy in patients with upper tract urothelial cancer: a systematic review and Meta-analysis

Author

Tsuboi, Ichiro, Matsukawa, Akihiro, Kardoust Parizi, Mehdi, Klemm, Jakob, Schulz, Robert J, Cadenar, Anna, Mancon, Stefano, Chiujdea, Sever, Fazekas, Tamás, Miszczyk, Marcin, Laukhtina, Ekaterina, Kawada, Tatsushi, Katayama, Satoshi, Iwata, Takehiro, Bekku, Kensuke, Wada, Koichiro, Gontero, Paolo, Rouprêt, Morgan, Teoh, Jeremy, Singla, Nirmish, Araki, Motoo, and Shariat, Shahrokh F.

Published
2024
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3. External validation and comparison of magnetic resonance imaging-based risk prediction models for prostate biopsy stratification

Author

Diamand, Romain, Guenzel, Karsten, Jabbour, Teddy, Baudewyns, Arthur, Bourgeno, Henri-Alexandre, Lefebvre, Yolène, Ferriero, Mariaconsiglia, Simone, Giuseppe, Fourcade, Alexandre, Fournier, Georges, Bui, Alexandre Patrick, Taha, Fayek, Oderda, Marco, Gontero, Paolo, Rysankova, Katerina, Bernal-Gomez, Adrian, Mastrorosa, Alessandro, Roche, Jean-Baptiste, Fiard, Gaelle, Abou Zahr, Rawad, Ploussard, Guillaume, Windisch, Olivier, Novello, Quentin, Benamran, Daniel, Delavar, Gina, Anract, Julien, Barry Delongchamps, Nicolas, Halinski, Adam, Dariane, Charles, Vlahopoulos, Léonidas, Assenmacher, Gregoire, Roumeguère, Thierry, and Peltier, Alexandre

Published
2024
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4. The impact of prostate volume estimation on the risk‐adapted biopsy decision based on prostate-specific antigen density and magnetic resonance imaging score

Author

Baudewyns, Arthur, Guenzel, Karsten, Halinski, Adam, Dariane, Charles, Delavar, Gina, Anract, Julien, Barry Delongchamps, Nicolas, Jabbour, Teddy, Bourgeno, Henri-Alexandre, Lefebvre, Yolène, Ferriero, Mariaconsiglia, Simone, Giuseppe, Fourcade, Alexandre, Fournier, Georges, Oderda, Marco, Gontero, Paolo, Bernal-Gomez, Adrian, Mastrorosa, Alessandro, Roche, Jean-Baptiste, Zahr, Rawad Abou, Ploussard, Guillaume, Fiard, Gaelle, Rysankova, Katerina, Bui, Alexandre Patrick, Taha, Fayek, Windisch, Olivier, Benamran, Daniel, Vlahopoulos, Léonidas, Assenmacher, Gregoire, Roumeguère, Thierry, Peltier, Alexandre, and Diamand, Romain

Published
2024
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8. Diagnosis of prostate cancer with magnetic resonance imaging in men treated with 5-alpha-reductase inhibitors

Author

Falagario, Ugo G., Lantz, Anna, Jambor, Ivan, Busetto, Gian Maria, Bettocchi, Carlo, Finati, Marco, Ricapito, Anna, Luzzago, Stefano, Ferro, Matteo, Musi, Gennaro, Totaro, Angelo, Racioppi, Marco, Carbonara, Umberto, Checcucci, Enrico, Manfredi, Matteo, D’Aietti, Damiano, Porcaro, Antonio Benito, Nordström, Tobias, Björnebo, Lars, Oderda, Marco, Soria, Francesco, Taimen, Pekka, Aronen, Hannu J., Perez, Ileana Montoya, Ettala, Otto, Marchioni, Michele, Simone, Giuseppe, Ferriero, Mariaconsiglia, Brassetti, Aldo, Napolitano, Luigi, Carmignani, Luca, Signorini, Claudia, Conti, Andrea, Ludovico, Giuseppe, Scarcia, Marcello, Trombetta, Carlo, Claps, Francesco, Traunero, Fabio, Montanari, Emanuele, Boeri, Luca, Maggi, Martina, Del Giudice, Francesco, Bove, Pierluigi, Forte, Valerio, Ficarra, Vincenzo, Rossanese, Marta, Mucciardi, Giuseppe, Pagliarulo, Vincenzo, Tafuri, Alessandro, Mirone, Vincenzo, Schips, Luigi, Antonelli, Alessandro, Gontero, Paolo, Cormio, Luigi, Sciarra, Alessandro, Porpiglia, Francesco, Bassi, PierFrancesco, Ditonno, Pasquale, Boström, Peter J., Messina, Emanuele, Panebianco, Valeria, De Cobelli, Ottavio, and Carrieri, Giuseppe

Published
2023
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11. En bloc resection of bladder tumour: the rebirth of past through reminiscence

Author

Teoh, Jeremy Yuen-Chun, D’Andrea, David, Gallioli, Andrea, Yanagisawa, Takafumi, MacLennan, Steven, Nicoletti, Rossella, Fai, Ng Chi, Maffei, Davide, Hurle, Rodolfo, Lusuardi, Lukas, Malavaud, Bernard, Miki, Jun, Kramer, Mario, Mostafid, Hugh, Enikeev, Dmitry, Babjuk, Marek, Breda, Alberto, Shariat, Shahrokh, Gontero, Paolo, and Herrmann, Thomas

Published
2023
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13. Active surveillance in renal transplant patients with prostate cancer: a multicentre analysis

Author

Soeterik, Timo F. W., van den Bergh, Roderick C. N., van Melick, Harm H. E., Kelder, Hans, Peretti, Federica, Dariane, Charles, Timsit, Marc-Olivier, Branchereau, Julien, Mesnard, Benoit, Tilki, Derya, Olsburgh, Jonathon, Kulkarni, Meghana, Kasivisvanathan, Veeru, Breda, Alberto, Biancone, Luigi, Gontero, Paolo, Gandaglia, Giorgio, and Marra, Giancarlo

Published
2023
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14. Changes in renal function after nephroureterectomy for upper urinary tract carcinoma: analysis of a large multicenter cohort (Radical Nephroureterectomy Outcomes (RaNeO) Research Consortium)

Author

Tafuri, Alessandro, Marchioni, Michele, Cerrato, Clara, Mari, Andrea, Tellini, Riccardo, Odorizzi, Katia, Veccia, Alessandro, Amparore, Daniele, Shakir, Aliasger, Carbonara, Umberto, Panunzio, Andrea, Trovato, Federica, Catellani, Michele, Janello, Letizia M. I., Bianchi, Lorenzo, Novara, Giacomo, Dal Moro, Fabrizio, Schiavina, Riccardo, De Lorenzis, Elisa, Parma, Paolo, Cimino, Sebastiano, De Cobelli, Ottavio, Maiorino, Francesco, Bove, Pierluigi, Crocerossa, Fabio, Cantiello, Francesco, D’Andrea, David, Di Cosmo, Federica, Porpiglia, Francesco, Ditonno, Pasquale, Montanari, Emanuele, Soria, Francesco, Gontero, Paolo, Liguori, Giovanni, Trombetta, Carlo, Mantica, Guglielmo, Borghesi, Marco, Terrone, Carlo, Del Giudice, Francesco, Sciarra, Alessandro, Galosi, Andrea, Moschini, Marco, Shariat, Shahrokh F., Di Nicola, Marta, Minervini, Andrea, Ferro, Matteo, Cerruto, Maria Angela, Schips, Luigi, Pagliarulo, Vincenzo, and Antonelli, Alessandro

Published
2022
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15. Immediate radical cystectomy versus BCG immunotherapy for T1 high-grade non-muscle-invasive squamous bladder cancer: an international multi-centre collaboration

Author

Lonati , Chiara, Afferi, Luca, Mari, Andrea, Minervini, Andrea, Krajewski, Wojciech, Borghesi, Marco, Schulz, Gerald B., Rink, Michael, Montorsi, Francesco, Briganti, Alberto, Colombo, Renzo, Martini, Alberto, Necchi, Andrea, Contieri, Roberto, Hurle, Rodolfo, Umari, Paolo, Zamboni, Stefania, Simeone, Claudio, Soria, Francesco, Marra, Giancarlo, Gontero, Paolo, Teoh, Jeremy Yuen-Chun, Klatte, Tobias, Bajeot, Anne-Sophie, Roumiguié, Mathieu, Rouprêt, Morgan, Masson-Lecomte, Alexandra, Laukhtina, Ekaterina, Valiquette, Anne Sophie, Mir, M. Carmen, Antonelli, Alessandro, Einerhand, Sarah M. H., Hendricksen, Kees, Carando, Roberto, Fankhauser, Christian D., Baumeister, Philipp, Mattei, Agostino, Shariat, Shahrokh F., and Moschini, Marco

Published
2022
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19. Association of patients’ sex with treatment outcomes after intravesical bacillus Calmette–Guérin immunotherapy for T1G3/HG bladder cancer

Author

D’Andrea, David, Soria, Francesco, Grotenhuis, Anne J., Cha, Eugene K., Malats, Nuria, Di Stasi, Savino, Joniau, Steven, Cai, Tommaso, van Rhijn, Bas W. G., Irani, Jaques, Karnes, Jeffrey, Varkarakis, John, Baniel, Jack, Palou, Joan, Babjuk, Marek, Spahn, Martin, Ardelt, Peter, Colombo, Renzo, Serretta, Vincenzo, Dalbagni, Guido, Gontero, Paolo, Bartoletti, Riccardo, Larré, Stephane, Malmstrom, Per-Uno, Sylvester, Richard, and Shariat, Shahrokh F.

Published
2021
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22. A multicentric study on accurate grading of prostate cancer with systematic and MRI/US fusion targeted biopsies: comparison with final histopathology after radical prostatectomy

Author

Diamand, R., Oderda, M., Al Hajj Obeid, W., Albisinni, S., Van Velthoven, R., Fasolis, G., Simone, G., Ferriero, M., Roche, J-B., Piechaud, T., Pastore, A., Carbone, A., Fiard, G., Descotes, J-L., Marra, G., Gontero, P., Altobelli, E., Papalia, R., Kumar, P., Eldred-Evans, D., Giacobbe, A., Muto, G., Lacetera, V., Beatrici, V., Roumeguere, T., and Peltier, A.

Published
2019
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27. Predictors of oncological outcomes in T1G3 patients treated with BCG who undergo radical cystectomy

Author

Soria, Francesco, Pisano, Francesca, Gontero, Paolo, Palou, J., Joniau, S., Serretta, V., Larré, S., Di Stasi, S., van Rhijn, B., Witjes, J. A., Grotenhuis, A., Colombo, R., Briganti, A., Babjuk, M., Soukup, V., Malmstrom, P. U., Irani, J., Malats, N., Baniel, J., Mano, R., Cai, T., Cha, E., Ardelt, P., Varkarakis, J., Bartoletti, R., Dalbagni, G., Shariat, S. F., Xylinas, E., Karnes, R. J., and Sylvester, R.

Published
2018
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29. Recurrence, progression and cancer-specific mortality according to stage at re-TUR in T1G3 bladder cancer patients treated with BCG: not as bad as previously thought

Author

Palou, J., Pisano, F., Sylvester, R., Joniau, S., Serretta, V., Larré, S., Di Stasi, S., van Rhijn, B., Witjes, A. J., Grotenhuis, A., Colombo, R., Briganti, A., Babjuk, M., Soukup, V., Malmstrom, P. U., Irani, J., Malats, N., Baniel, J., Mano, R., Cai, T., Cha, E. K., Ardelt, P., Varkarakis, J., Bartoletti, R., Dalbagni, G., Shariat, S. F., Xylinas, E., Karnes, R. J., and Gontero, P.

Published
2018
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34. Female gender is associated with higher risk of disease recurrence in patients with primary T1 high-grade urothelial carcinoma of the bladder

Author

Kluth, Luis A., Fajkovic, Harun, Xylinas, Evanguelos, Crivelli, Joseph J., Passoni, Niccolo, Rouprêt, Morgan, Becker, Andreas, Comploj, Evi, Pycha, Armin, Holmang, Sten, Gupta, Amit, Lotan, Yair, Karakiewicz, Pierre I., Gontero, Paolo, Chun, Felix K.-H., Fisch, Margit, Scherr, Douglas S., and Shariat, Shahrokh F.

Published
2013
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35. External validation of the preoperative Karakiewicz nomogram in a large multicentre series of patients with renal cell carcinoma

Author

Gontero, Paolo, Sun, Maxine, Antonelli, Alessandro, Bertini, Roberto, Carini, Marco, Carmignani, Giorgio, Longo, Nicola, Martorana, Giuseppe, Minervini, Andrea, Mirone, Vincenzo, Morgia, Giuseppe, Novara, Giacomo, Oderda, Marco, Simeone, Claudio, Simonato, Alchiede, Siracusano, Salvatore, Tizzani, Alessandro, Volpe, Alessandro, Karakiewicz, Pierre, Ficarra, Vincenzo, and Members of the SATURN Project–LUNA Foundation

Published
2013
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38. Changes in renal function after nephroureterectomy for upper urinary tract carcinoma: analysis of a large multicenter cohort (Radical Nephroureterectomy Outcomes (RaNeO) Research Consortium)

Author

Alessandro Tafuri, Michele Marchioni, Clara Cerrato, Andrea Mari, Riccardo Tellini, Katia Odorizzi, Alessandro Veccia, Daniele Amparore, Aliasger Shakir, Umberto Carbonara, Andrea Panunzio, Federica Trovato, Michele Catellani, Letizia M. I. Janello, Lorenzo Bianchi, Giacomo Novara, Fabrizio Dal Moro, Riccardo Schiavina, Elisa De Lorenzis, Paolo Parma, Sebastiano Cimino, Ottavio De Cobelli, Francesco Maiorino, Pierluigi Bove, Fabio Crocerossa, Francesco Cantiello, David D’Andrea, Federica Di Cosmo, Francesco Porpiglia, Pasquale Ditonno, Emanuele Montanari, Francesco Soria, Paolo Gontero, Giovanni Liguori, Carlo Trombetta, Guglielmo Mantica, Marco Borghesi, Carlo Terrone, Francesco Del Giudice, Alessandro Sciarra, Andrea Galosi, Marco Moschini, Shahrokh F. Shariat, Marta Di Nicola, Andrea Minervini, Matteo Ferro, Maria Angela Cerruto, Luigi Schips, Vincenzo Pagliarulo, Alessandro Antonelli, Tafuri, Alessandro, Marchioni, Michele, Cerrato, Clara, Mari, Andrea, Tellini, Riccardo, Odorizzi, Katia, Veccia, Alessandro, Amparore, Daniele, Shakir, Aliasger, Carbonara, Umberto, Panunzio, Andrea, Trovato, Federica, Catellani, Michele, Janello, Letizia M I, Bianchi, Lorenzo, Novara, Giacomo, Dal Moro, Fabrizio, Schiavina, Riccardo, De Lorenzis, Elisa, Parma, Paolo, Cimino, Sebastiano, De Cobelli, Ottavio, Maiorino, Francesco, Bove, Pierluigi, Crocerossa, Fabio, Cantiello, Francesco, D'Andrea, David, Di Cosmo, Federica, Porpiglia, Francesco, Ditonno, Pasquale, Montanari, Emanuele, Soria, Francesco, Gontero, Paolo, Liguori, Giovanni, Trombetta, Carlo, Mantica, Guglielmo, Borghesi, Marco, Terrone, Carlo, Del Giudice, Francesco, Sciarra, Alessandro, Galosi, Andrea, Moschini, Marco, Shariat, Shahrokh F, Di Nicola, Marta, Minervini, Andrea, Ferro, Matteo, Cerruto, Maria Angela, Schips, Luigi, Pagliarulo, Vincenzo, Antonelli, Alessandro, Tafuri A., Marchioni M., Cerrato C., Mari A., Tellini R., Odorizzi K., Veccia A., Amparore D., Shakir A., Carbonara U., Panunzio A., Trovato F., Catellani M., Janello L.M.I., Bianchi L., Novara G., Dal Moro F., Schiavina R., De Lorenzis E., Parma P., Cimino S., De Cobelli O., Maiorino F., Bove P., Crocerossa F., Cantiello F., D'Andrea D., Di Cosmo F., Porpiglia F., Ditonno P., Montanari E., Soria F., Gontero P., Liguori G., Trombetta C., Mantica G., Borghesi M., Terrone C., Del Giudice F., Sciarra A., Galosi A., Moschini M., Shariat S.F., Di Nicola M., Minervini A., Ferro M., Cerruto M.A., Schips L., Pagliarulo V., and Antonelli A.

Subjects
Male, Urologic Neoplasms, Acute Kidney Injury, Chronic Kidney Disease, Radical Nephroureterectomy, Upper tract urothelial carcinoma, Humans, Infant, Nephroureterectomy, Nephrectomy, Glomerular Filtration Rate, Retrospective Studies, Kidney, Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Urinary Tract, Ureteral Neoplasms, Urology, Retrospective Studie, Upper tract urothelial carcinoma, Radical Nephroureterectomy, Acute Kidney Injury, Chronic Kidney Disease, Carcinoma, Urologic Neoplasm, Urinary Bladder Neoplasm, Transitional Cell, Human
Abstract

Purpose To investigate prevalence and predictors of renal function variation in a multicenter cohort treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Methods Patients from 17 tertiary centers were included. Renal function variation was evaluated at postoperative day (POD)—1, 6 and 12 months. Timepoints differences were Δ1 = POD-1 eGFR − baseline eGFR; Δ2 = 6 months eGFR − POD-1 eGFR; Δ3 = 12 months eGFR − 6 months eGFR. We defined POD-1 acute kidney injury (AKI) as an increase in serum creatinine by ≥ 0.3 mg/dl or a 1.5 1.9-fold from baseline. Additionally, a cutoff of 60 ml/min in eGFR was considered to define renal function decline at 6 and 12 months. Logistic regression (LR) and linear mixed (LM) models were used to evaluate the association between clinical factors and eGFR decline and their interaction with follow-up. Results A total of 576 were included, of these 409(71.0%) and 403(70.0%) had an eGFR p p = 0.003), POD-1 AKI (OR 2.88, p p p p = 0.007), POD-1 AKI (OR 1.83, p = 0.02), and preoperative eGFR p p = 0.019), hydronephrosis (p p p = 0.001) influenced renal function variation (ß 9.2 ± 0.7, p Conclusion Age, preoperative eGFR and POD-1 AKI are independent predictors of 6 and 12 months renal function decline after RNU for UTUC.

Published
2022

39. Older patients with low Charlson score and high-risk prostate cancer benefit from radical prostatectomy

Author

M. Graefen, Giansilvio Marchioro, X. Cathelineau, Patrick J. Bastian, Martin Spahn, Marco Bianchi, Steven Joniau, R. Jeffrey Karnes, Bertrand Tombal, Piotr Chlosta, L. Tosco, Arjun Sivaraman, P. Dell’Oglio, P. Gontero, Alberto Briganti, H Henk van der Poel, J. Chun, R. Sanchez-Salas, G. Ordaz Jurado, Eric Barret, Sivaraman, A., Ordaz Jurado, G., Cathelineau, X., Barret, Eric, Dell’Oglio, P., Joniau, S., Bianchi, M., Briganti, A., Spahn, M., Bastian, P., Chun, J., Chlosta, P., Gontero, P., Graefen, M., Jeffrey Karnes, R., Marchioro, G., Tombal, B., Tosco, L., van der Poel, H. Henk, and Sanchez-Salas, R.

Subjects
Male, Oncology, Time Factors, Biopsy, medicine.medical_treatment, 030232 urology & nephrology, Prostate cancer, 0302 clinical medicine, Retrospective Studie, Risk Factors, 610 Medicine & health, Prostatectomy, Prostate, Area under the curve, Radical prostatectomy, Survival Rate, 030220 oncology & carcinogenesis, France, Human, High-risk prostate cancer, medicine.medical_specialty, Time Factor, Urology, Risk Assessment, Follow-Up Studie, 03 medical and health sciences, Internal medicine, medicine, Humans, Survival rate, Survival analysis, Aged, Retrospective Studies, business.industry, Risk Factor, Prostatic Neoplasms, Cancer, Retrospective cohort study, medicine.disease, Log-rank test, Charlson comorbidity index, Survival benefit, Prostatic Neoplasm, Neoplasm Grading, business, Follow-Up Studies
Abstract

Introduction: The aim of the study was to identify the appropriate level of Charlson comorbidity index (CCI) in older patients (>70 years) with high-risk prostate cancer (PCa) to achieve survival benefit following radical prostatectomy (RP). Methods: We retrospectively analyzed 1008 older patients (>70 years) who underwent RP with pelvic lymph node dissection for high-risk prostate cancer (preoperative prostate-specific antigen >20 ng/mL or clinical stage ≥T2c or Gleason ≥8) from 14 tertiary institutions between 1988 and 2014. The study population was further grouped into CCIÂ

Published
2016

40. Association of patients' sex with treatment outcomes after intravesical bacillus Calmette-Guérin immunotherapy for T1G3/HG bladder cancer.

Author

D'Andrea D, Soria F, Grotenhuis AJ, Cha EK, Malats N, Di Stasi S, Joniau S, Cai T, van Rhijn BWG, Irani J, Karnes J, Varkarakis J, Baniel J, Palou J, Babjuk M, Spahn M, Ardelt P, Colombo R, Serretta V, Dalbagni G, Gontero P, Bartoletti R, Larré S, Malmstrom PU, Sylvester R, and Shariat SF

Subjects
Administration, Intravesical, Aged, Female, Humans, Male, Middle Aged, Neoplasm Grading, Retrospective Studies, Sex Factors, Treatment Outcome, Adjuvants, Immunologic administration & dosage, BCG Vaccine administration & dosage, Immunotherapy, Urinary Bladder Neoplasms drug therapy, Urinary Bladder Neoplasms pathology
Abstract

Purpose: To investigate the association of patients' sex with recurrence and disease progression in patients treated with intravesical bacillus Calmette-Guérin (BCG) for T1G3/HG urinary bladder cancer (UBC)., Materials and Methods: We analyzed the data of 2635 patients treated with adjuvant intravesical BCG for T1 UBC between 1984 and 2019. We accounted for missing data using multiple imputations and adjusted for covariate imbalance between males and females using inverse probability weighting (IPW). Crude and IPW-adjusted Cox regression analyses were used to estimate the hazard ratios (HR) with their 95% confidence intervals (CI) for the association of patients' sex with HG-recurrence and disease progression., Results: A total of 2170 (82%) males and 465 (18%) females were available for analysis. Overall, 1090 (50%) males and 244 (52%) females experienced recurrence, and 391 (18%) males and 104 (22%) females experienced disease progression. On IPW-adjusted Cox regression analyses, female sex was associated with disease progression (HR 1.25, 95%CI 1.01-1.56, p = 0.04) but not with recurrence (HR 1.06, 95%CI 0.92-1.22, p = 0.41). A total of 1056 patients were treated with adequate BCG. In these patients, on IPW-adjusted Cox regression analyses, patients' sex was not associated with recurrence (HR 0.99, 95%CI 0.80-1.24, p = 0.96), HG-recurrence (HR 1.00, 95%CI 0.78-1.29, p = 0.99) or disease progression (HR 1.12, 95%CI 0.78-1.60, p = 0.55)., Conclusion: Our analysis generates the hypothesis of a differential response to BCG between males and females if not adequately treated. Further studies should focus on sex-based differences in innate and adaptive immune system and their association with BCG response., (© 2021. The Author(s).)

Published
2021
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41. Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases.

Author

Gontero P, Pisano F, Palou J, Joniau S, Albersen M, Colombo R, Briganti A, Pellucchi F, Faba OR, van Rhijn BW, van de Putte EF, Babjuk M, Fritsche HM, Mayr R, Albers P, Niegisch G, Anract J, Masson-Lecomte A, De la Taille A, Roupret M, Peyronnet B, Cai T, Witjes AJ, Bruins M, Baniel J, Mano R, Lapini A, Sessa F, Irani J, Brausi M, Stenzl A, Karnes JR, Scherr D, O'Malley P, Taylor B, Shariat SF, Black P, Abdi H, Matveev VB, Samuseva O, Parekh D, Gonzalgo M, Vetterlein MW, Aziz A, Fisch M, Catto J, Pang KH, Xylinas E, and Rink M

Subjects
Aged, Female, Humans, Internationality, Male, Middle Aged, Retrospective Studies, Risk Assessment, Abdominal Neoplasms radiotherapy, Cystectomy, Postoperative Complications epidemiology, Urinary Bladder radiation effects, Urinary Bladder Neoplasms surgery
Abstract

Purpose: Conflicting evidence exists on the complication rates after cystectomy following previous radiation (pRTC) with only a few available series. We aim to assess the complication rate of pRTC for abdominal-pelvic malignancies., Methods: Patients treated with radical cystectomy following any previous history of RT and with available information on complications for a minimum of 1 year were included. Univariable and multivariable logistic regression models were used to assess the relationship between the variable parameters and the risk of any complication., Results: 682 patients underwent pRTC after a previous RT (80.5% EBRT) for prostate, bladder (BC), gynecological or other cancers in 49.1%, 27.4%, 9.8% and 12.9%, respectively. Overall, 512 (75.1%) had at least one post-surgical complication, classified as Clavien ≥ 3 in 29.6% and Clavien V in 2.9%. At least one surgical complication occurred in 350 (51.3%), including bowel leakage in 6.2% and ureteric stricture in 9.4%. A medical complication was observed in 359 (52.6%) patients, with UTI/pyelonephritis being the most common (19%), followed by renal failure (12%). The majority of patients (86%) received an incontinent urinary diversion. In multivariable analysis adjusted for age, gender and type of RT, patients treated with RT for bladder cancer had a 1.7 times increased relative risk of experiencing any complication after RC compared to those with RT for prostate cancer (p = 0.023). The type of diversion (continent vs non-continent) did not influence the risk of complications., Conclusion: pRTC carries a high rate of major complications that dramatically exceeds the rates reported in RT-naïve RCs.

Published
2020
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