1. Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature
- Author
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Xiaodong He, Cheng Feng, Zhao-hui Lu, Lei Wang, Wei Liu, and Xiao-yan Chang
- Subjects
medicine.medical_specialty ,Cholecyst ,medicine.medical_treatment ,Case Report ,Adenocarcinoma ,Neuroendocrine tumors ,Gastroenterology ,Metastasis ,Neoplasms, Multiple Primary ,Surgical oncology ,Neoplasms ,Internal medicine ,medicine ,Carcinoma ,Humans ,Large-cell neuroendocrine carcinoma ,business.industry ,Gallbladder ,Middle Aged ,Prognosis ,medicine.disease ,Carcinoma, Neuroendocrine ,medicine.anatomical_structure ,Oncology ,Carcinoma, Large Cell ,Female ,Gallbladder Neoplasms ,Surgery ,Cholecystectomy ,Tomography, X-Ray Computed ,business - Abstract
Large-cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare. We present a 63-year-old Chinese female who was admitted with right upper quadrant pain and a quasi-circular tumor measuring 2.0 cm on the body of the gallbladder, as indicated by computed tomography. LCNEC combined with adenocarcinoma was immunohistochemically confirmed after open radical cholecystectomy. Postoperative recovery of this patient was uneventful, and no evidence of recurrence or metastasis was observed after 12 months of follow-up. LCNEC of the gallbladder is thought to be extremely rare and is usually found in combination with other histological carcinoma types, such as adenocarcinoma, as determined histologically. The prognosis is poor overall, but early detection with complete resection may result in a relatively good prognosis.
- Published
- 2015