1. Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy
- Author
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Canming Chen, Zhi-Ming Shao, Tianwen Chen, Sheng Chen, Jiong Wu, Liang Huang, and Yin Liu
- Subjects
Oncology ,Receptor, ErbB-2 ,medicine.medical_treatment ,HER2/neu ,Immunoenzyme Techniques ,Breast cancer ,Surgical oncology ,Antineoplastic Combined Chemotherapy Protocols ,Overall survival ,Lymph node ,Neoadjuvant therapy ,Mitogen-Activated Protein Kinase 1 ,Mitogen-Activated Protein Kinase 3 ,biology ,Vinorelbine ,Middle Aged ,Prognosis ,Neoadjuvant Therapy ,Survival Rate ,medicine.anatomical_structure ,Female ,Fluorouracil ,Epirubicin ,medicine.drug ,Relapse-free survival ,Adult ,medicine.medical_specialty ,Anthracycline ,pAKT ,Breast Neoplasms ,Prognostic factors ,Vinblastine ,Neoadjuvant chemotherapy ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Cyclophosphamide ,Survival rate ,Aged ,Neoplasm Staging ,Retrospective Studies ,Phospho-p44/42 ,business.industry ,Research ,medicine.disease ,biology.protein ,Surgery ,business ,Proto-Oncogene Proteins c-akt ,Follow-Up Studies - Abstract
Background To evaluate the predictive and prognostic value of various molecular factors associated with the Ras/MAPK and PI3K/Akt signaling pathways in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy (NAC). Methods A total of 113 patients were recruited in this retrospective study. Core needle biopsies and excision samples were assessed through immunohistochemistry for various biomarkers, including IGF-1R, Phospho-p44/42, Ki67, pAKT, PTEN, p27, and cyclinD1. The changes in these biomarkers after NAC and their predictive and prognostic values were investigated. Results Significant decreases in Ki67, Phospho-p44/42, and pAKT expression were observed after treatment (30.7% vs. 18.1%, 36.4% vs. 18.9%, and 35.1% vs. 16.4%, respectively). The decreases in Phospho-p44/42, pAKT, and Ki67 expression were strongly associated with the response to anthracycline treatment (P = 0.027, P = 0.031, and P = 0.008, respectively). In a multivariate survival analysis, Phospho-p44/42 expression after neoadjuvant chemotherapy and lymph node status were significant independent prognostic factors of both relapse-free survival and overall survival. Conclusions Reductions in Ki-67, Phospho-p44/42, and pAKT expression are related to the clinical response to anthracycline-based NAC in HER2-positive breast cancer patients. High pAKT expression prior to NAC had a better clinical response. Phospho-p44/42 expression and lymph node status after NAC could be useful for determining relapse-free survival and overall survival.
- Published
- 2013
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