1. The impact and optimal indication of non-curative gastric resection for stage IV advanced gastric cancer diagnosed during surgery: 10 years of experience at a single institute
- Author
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Nobutaka Tanaka, Yukihiro Nomura, Naoya Yamada, and Atsushi Akai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Non-curative gastric resection ,Adenocarcinoma ,Metastasis ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Gastrectomy ,Risk Factors ,Stomach Neoplasms ,Stage IV gastric cancer ,Postoperative chemotherapy ,Medicine ,Humans ,Survival rate ,Survival analysis ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Research ,Hazard ratio ,Cancer ,Middle Aged ,medicine.disease ,Prognosis ,Surgery ,Survival Rate ,Oncology ,030220 oncology & carcinogenesis ,Distant Lymph Node ,030211 gastroenterology & hepatology ,Female ,business ,Abdominal surgery ,Follow-Up Studies - Abstract
Background The survival benefit of non-curative gastric resection for patients with stage IV gastric cancer is still unclear. Methods Of the patients who underwent open abdominal surgery that was preoperatively intended to be a radical excision procedure for gastric cancer, 72 were diagnosed with stage IV during the operation. At this institution, non-curative gastric resection is performed whenever possible. Results Non-curative gastric resection was performed in 44 of the 72 patients. According to the survival analysis, the median survival times in the gastric resection and no-resection groups were 1.9 and 0.9 years, respectively (log-rank test, p = 0.014). Based on the multivariate analysis, we selected gastric resection (hazard ratio [HR] = 0.309; 95 % confidence interval [CI] = 0.152–0.615) and postoperative chemotherapy (HR = 0.136; 95 % CI = 0.056–0.353) as independent factors associated with overall survival (OS). In the subgroup analyses of OS, the factors that were associated with gastric resection having no survival benefit were the existence of distant lymph node or liver metastasis (p = 0.527) and the lack of postoperative chemotherapy (p = 0.589). Conclusions For patients who have distant lymph node or liver metastasis and those who will not undergo postoperative chemotherapy, non-curative gastric resection has no survival benefit.
- Published
- 2015