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Your search keyword '"Zhen-Ya Lu"' showing total 4 results
Start Over Author "Zhen-Ya Lu" Journal world journal of gastroenterology
4 results on '"Zhen-Ya Lu"'

1. Prevalence of and risk factors for non-alcoholic fatty liver disease in a Chinese population: An 8-year follow-up study

Author

Zhen-Ya Lu, Xin-Hua Chen, Ya-Li Li, Zhou Shao, and Muhuyati Wulasihan

Subjects
0301 basic medicine, Blood Glucose, Male, Time Factors, Prevalence, Blood lipids, Disease, Body Mass Index, 0302 clinical medicine, Blood serum, Non-alcoholic Fatty Liver Disease, Risk Factors, Epidemiology, Fatty liver, Gastroenterology, General Medicine, Middle Aged, Study of Health in Pomerania, 030211 gastroenterology & hepatology, Female, Adult, medicine.medical_specialty, China, Observational Study, Hyperuricemia, digestive system, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, Obesity, Triglycerides, Aged, Dyslipidemias, business.industry, Cholesterol, HDL, Urban Health, nutritional and metabolic diseases, Cholesterol, LDL, Protective Factors, medicine.disease, digestive system diseases, Uric Acid, 030104 developmental biology, Cross-Sectional Studies, Hyperglycemia, Liver function, business, Risk Reduction Behavior, Biomarkers, Follow-Up Studies
Abstract

To investigate the prevalence of and risk factors for non-alcoholic fatty liver disease (NAFLD) in a Chinese population.A total of 1948 adults from China was followed for 8 years. A cross-sectional study was performed to investigate the prevalence of NAFLD at baseline, and then the participants were followed for 8 years to investigate risk factors for the development of NAFLD.A total of 1948 participants were enrolled at baseline, of whom 691 were diagnosed with NAFLD. During the 8-year follow-up, 337 baseline NAFLD-free participants developed NAFLD. They had a greater increase in body mass index (BMI), serum uric acid, fasting plasma glucose, very low-density lipoprotein cholesterol and a considerable decrease in high-density lipoprotein cholesterol. 123 participants who had NAFLD at baseline lost NAFLD during the 8-year follow-up period. They had a greater decrease in BMI, fasting plasma glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transpeptidase.NAFLD is prevalent in Chinese population with a rapidly increasing tendency. It can be reversed when patients lose their weight, control their hyperlipidemia and hyperglycemia, and reduce the liver enzyme levels.

Published
2015

2. A large congenital and solitary intrahepatic arterioportal fistula in an old woman

Author

Zhen-Ya Lu, Zhan-Kun Wang, Tian-An Jiang, Jian-Yang Ao, and Zhi-Yi Peng

Subjects
Male, medicine.medical_specialty, Adolescent, Fistula, medicine.medical_treatment, Case Report, Asymptomatic, Hepatic Artery, Biopsy, Hypertension, Portal, medicine, Arterioportal fistula, Humans, Embolization, Aged, medicine.diagnostic_test, business.industry, Gastroenterology, General Medicine, medicine.disease, Embolization, Therapeutic, Surgery, Radiography, medicine.anatomical_structure, Treatment Outcome, Arteriovenous Fistula, Portal hypertension, Female, Radiology, Upper gastrointestinal bleeding, medicine.symptom, business, Gastrointestinal Hemorrhage, Artery
Abstract

Arterioportal fistula (APF) is a rare cause of portal hypertension and may lead to death. APF can be congenital, post-traumatic, iatrogenic (transhepatic intervention or biopsy) or related to ruptured hepatic artery aneurysms. Congenital APF is a rare condition even in children. In this case report, we describe a 73-year-old woman diagnosed as APF by ultrasonography, computed tomography, and hepatic artery selective arteriography. The fistula was embolized twice but failed, and she still suffered from alimentary tract hemorrhage. Then, selective arteriography of the hepatic artery was performed again and venae coronaria ventriculi and short gastric vein were embolized. During the 2-year follow-up, the patient remained asymptomatic. We therefore argue that embolization of venae coronaria ventriculi and short gastric vein may be an effective treatment modality for intrahepatic APF with severe upper gastrointestinal bleeding.

Published
2009

3. Prevalence of and risk factors for non-alcoholic fatty liver disease in a Chinese population: An 8-year follow-up study.

Author

Lu ZY, Shao Z, Li YL, Wulasihan M, and Chen XH

Subjects
Adult, Aged, Biomarkers blood, Blood Glucose metabolism, Body Mass Index, China epidemiology, Cholesterol, HDL blood, Cholesterol, LDL blood, Cross-Sectional Studies, Dyslipidemias diagnosis, Dyslipidemias epidemiology, Female, Follow-Up Studies, Humans, Hyperglycemia diagnosis, Hyperglycemia epidemiology, Hyperuricemia diagnosis, Hyperuricemia epidemiology, Male, Middle Aged, Non-alcoholic Fatty Liver Disease blood, Non-alcoholic Fatty Liver Disease diagnosis, Non-alcoholic Fatty Liver Disease prevention & control, Obesity diagnosis, Obesity epidemiology, Prevalence, Protective Factors, Risk Factors, Risk Reduction Behavior, Time Factors, Triglycerides blood, Uric Acid blood, Young Adult, Non-alcoholic Fatty Liver Disease epidemiology, Urban Health
Abstract

Aim: To investigate the prevalence of and risk factors for non-alcoholic fatty liver disease (NAFLD) in a Chinese population., Methods: A total of 1948 adults from China was followed for 8 years. A cross-sectional study was performed to investigate the prevalence of NAFLD at baseline, and then the participants were followed for 8 years to investigate risk factors for the development of NAFLD., Results: A total of 1948 participants were enrolled at baseline, of whom 691 were diagnosed with NAFLD. During the 8-year follow-up, 337 baseline NAFLD-free participants developed NAFLD. They had a greater increase in body mass index (BMI), serum uric acid, fasting plasma glucose, very low-density lipoprotein cholesterol and a considerable decrease in high-density lipoprotein cholesterol. 123 participants who had NAFLD at baseline lost NAFLD during the 8-year follow-up period. They had a greater decrease in BMI, fasting plasma glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transpeptidase., Conclusion: NAFLD is prevalent in Chinese population with a rapidly increasing tendency. It can be reversed when patients lose their weight, control their hyperlipidemia and hyperglycemia, and reduce the liver enzyme levels.

Published
2016
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4. Association between serum α-L-fucosidase and non-alcoholic fatty liver disease: Cross-sectional study.

Author

Lu ZY, Cen C, Shao Z, Chen XH, Xu CF, and Li YM

Subjects
Adult, Area Under Curve, Biomarkers blood, Chi-Square Distribution, China epidemiology, Cross-Sectional Studies, Female, Humans, Linear Models, Logistic Models, Male, Metabolic Syndrome diagnosis, Metabolic Syndrome enzymology, Metabolic Syndrome epidemiology, Middle Aged, Multivariate Analysis, Non-alcoholic Fatty Liver Disease diagnosis, Non-alcoholic Fatty Liver Disease enzymology, Non-alcoholic Fatty Liver Disease epidemiology, Odds Ratio, Predictive Value of Tests, Prevalence, ROC Curve, Reproducibility of Results, Risk Factors, Up-Regulation, Metabolic Syndrome blood, Non-alcoholic Fatty Liver Disease blood, alpha-L-Fucosidase blood
Abstract

Aim: To explore the association between serum α-L-fucosidase (AFU) and non-alcoholic fatty liver disease (NAFLD)., Methods: A total of 16473 individuals (9456 men and 7017 women) were included in the current study, who presented for a health examination at the First Affiliated Hospital of Zhejiang University School of Medicine in 2014. The baseline characteristics of the cohort were compared by NAFLD status. Linear regression analysis and stepwise multiple regression analysis were applied to assess the risk factors for NAFLD. Receiver operating characteristic curve was used to determine the sensitivity and specificity of AFU in the diagnosis of NAFLD., Results: The prevalence rates of NAFLD and metabolic syndrome (MetS) were 38.0% and 25.4%, respectively. The NAFLD group had significantly higher AFU levels than the non-NAFLD group (28.7 ± 7.9 U/L vs 26.0 ± 7.3 U/L, P < 0.001) and the prevalence rate of NAFLD increased with progressively higher serum AFU levels. AFU was positively correlated with MetS and its five components: central obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, and elevated blood pressure and fasting glucose. Stepwise multiple logistic regression analysis showed that AFU was associated with an increased risk of NAFLD (OR = 1.009, 95%CI: 1.003-1.014, P < 0.001). The best cut-off value of AFU for the diagnosis of NAFLD was 27.5 U/L. The area under the curve (diagnostic efficacy index) was 0.606. The sensitivity and specificity were 54.6% and 61.8%, respectively., Conclusion: AFU level is significantly associated with NAFLD, and elevated AFU level is an independent risk factor for NAFLD.

Published
2016
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