1. Efficacy and safety of endoscopic submucosal tunnel dissection for superficial esophageal squamous cell carcinoma and precancerous lesions.
- Author
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Wang J, Zhu XN, Zhu LL, Chen W, Ma YH, Gan T, and Yang JL
- Subjects
- Adult, Aged, Aged, 80 and over, Blood Loss, Surgical, Carcinoma, Squamous Cell pathology, Esophageal Neoplasms pathology, Esophageal Perforation epidemiology, Esophageal Perforation etiology, Esophageal Squamous Cell Carcinoma, Esophageal Stenosis epidemiology, Esophageal Stenosis etiology, Esophagus pathology, Esophagus surgery, Female, Follow-Up Studies, Hospitalization statistics & numerical data, Humans, Incidence, Male, Middle Aged, Operative Time, Postoperative Complications etiology, Prospective Studies, Retrospective Studies, Treatment Outcome, Carcinoma, Squamous Cell surgery, Endoscopic Mucosal Resection adverse effects, Esophageal Neoplasms surgery, Esophagoscopy adverse effects, Postoperative Complications epidemiology, Precancerous Conditions surgery
- Abstract
Aim: To evaluate the clinical outcomes of patients who underwent endoscopic submucosal tunnel dissection (ESTD) for esophageal squamous cell carcinoma (ESCC) and precancerous lesions., Methods: ESTD was performed in 289 patients. The clinical outcomes of the patients and pathological features of the lesions were retrospectively reviewed., Results: A total of 311 lesions were included in the analysis. The en bloc rate, complete resection rate, and curative resection rate were 99.04%, 81.28%, and 78.46%, respectively. The ESTD procedure time was 102.4 ± 35.1 min, the mean hospitalization time was 10.3 ± 2.8 d, and the average expenditure was 3766.5 ± 846.5 dollars. The intraoperative bleeding rate was 6.43%, the postoperative bleeding rate was 1.61%, the perforation rate was 1.93%, and the postoperative infection rate was 9.65%. Esophageal stricture and positive margin were severe adverse events, with an incidence rate of 14.79% and 15.76%, respectively. No tumor recurrence occurred during the follow-up period., Conclusion: ESTD for ESCC and precancerous lesions is feasible and relatively safe, but for large mucosal lesions, the rate of esophageal stricture and positive margin is high., Competing Interests: Conflict-of-interest statement: We have no financial relationships to disclose.
- Published
- 2018
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