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Background: Galectin-3 and pentraxin-3 are recognized as cardiovascular risk factors, levels of which change in the pathological conditions, including type 2 diabetes. The aim of present research was to investigate the high and moderate intensity aerobic training effects on galectin-3, pentraxin-3, and some inflammatory mediators levels in type 2 diabetic women. Methods: Our study was a randomized clinical trial, conducted on the 36 type 2 diabetic women with an average age of 46.95±3.49 years old, randomly assigned to three equal groups, including control, continuous training with moderate-intensity (MICT), and high intensity interval training (HIIT) groups. Both MICT and HIIT program performed three sessions per week over a 12-week period. Training intensity in HIIT and MICT group was 90 and 60-70 percent of maximum heart rate, respectively. Blood samples at the baseline and after the 12-week training intervention were collected and the variables levels were measured via ELISA method. Repeated measures ANOVA test and Tukey post-hoc test were employed for data analysis. The research is documented in the Iranian Registry of Clinical Trials (registration number: IRCT20200729048252N1). Results: Galectin-3 levels significantly decreased in HIIT and MICT groups (p

Background: Exercise training and zataria multiflora exert anti-inflammatory effects alone and together; these anti-inflammatory effects are partly related to modulating adipokines secretion from adipose tissue. This research aimed to investigate the effect of combined training (aerobic-resistance) and zataria multiflora supplementation on serum resistin and retinol binding protein 4 (RBP-4) in sedentary women. Methods: The present randomized clinical trial, under the registration number IRCT20200812048388N1, was conducted in the winter and spring of 2021. The participants included 40 overweight and obese women who were assigned in four groups (10 women in each group), namely combined training with zataria multiflora (TZ), combined training (T), zataria multiflora (Z), and placebo (C) groups. Each combined training session consisted of 30 min of aerobic exercise, followed by 30 min of resistance exercise. Zataria multiflora supplement was also consumed at 500 mg daily. We carried out blood sampling before and after (48 hours after the last training session) the intervention period and measured the serum levels of RBP-4 and resistin via ELISA method. For data analysis, the SPSS software version 24, and analysis of covariance (ANCOVA) with Bonferroni post-hoc tests were used. Results: We observed a significant decrease in RBP-4 levels of T compared to that of C group (P=0.045), and in TZ compared to C and Z groups (p

Background: Exercise training and omega-3 supplementation are believed to have a positive effect on obese and overweight people. We conducted the present study in order to investigate the effect of aerobic training and omega3 ingestion on the levels of Adipsin and insulin resistance in overweight and obese women. Methods: In this semi-experimental study conducted in Tehran, summer 2020, 40 overweight and obese women (aged from 20 to 35 years old, and BMI 29.6±1.93 kg.m2) were assigned in four equal groups, namely placebo (P), omega-3 (O), training (E), and training+omega-3 (OE) groups. The subjects in the training and training+omega-3 groups completed the eight-week (three sessions per week) aerobic training program. 2000 mg omega-3 supplement was consumed on a daily basis. Blood samples were obtained before and after completing the intervention and Adipsin and insulin levels were measured. The data were analyzed via repeated measures analysis of variance (ANOVA) test along with Tukey post-hoc test. The study was approved under the IRCT registration code of IRCT20200811048360N1. Results: The findings of the present research shed light on a significant decrease in serum Adipsin levels in the E and OE groups compared to those in the P and O groups (p