Search

Your search keyword '"Selzer, Edgar"' showing total 6 results
Start Over Author "Selzer, Edgar" Journal wiener klinische wochenschrift
6 results on '"Selzer, Edgar"'

1. Ludwig Boltzmann Cluster Oncology (LBC ONC): first 10 years and future perspectives

Author

Valent, Peter, primary, Hadzijusufovic, Emir, additional, Grunt, Thomas, additional, Karlic, Heidrun, additional, Peter, Barbara, additional, Herrmann, Harald, additional, Eisenwort, Gregor, additional, Hoermann, Gregor, additional, Schulenburg, Axel, additional, Willmann, Michael, additional, Hubmann, Rainer, additional, Shehata, Medhat, additional, Selzer, Edgar, additional, Gleixner, Karoline V., additional, Rülicke, Thomas, additional, Sperr, Wolfgang R., additional, Marian, Brigitte, additional, Pfeilstöcker, Michael, additional, Pehamberger, Hubert, additional, Keil, Felix, additional, Jäger, Ulrich, additional, and Zielinski, Christoph, additional

Published
2018
Full Text
View/download PDF

5. Tumor-Stammzellforschung – Basis und Herausforderung für Diagnostik und Therapie

Author

Karlic, Heidrun, primary, Herrmann, Harald, additional, Schulenburg, Axel, additional, Grunt, Thomas W., additional, Laffer, Sylvia, additional, Mirkina, Irina, additional, Hubmann, Rainer, additional, Shehata, Medhat, additional, Marian, Brigitte, additional, Selzer, Edgar, additional, Pfeilstöcker, Michael, additional, Pittermann, Elisabeth, additional, Jäger, Ulrich, additional, Pehamberger, Hubert, additional, Zielinski, Christoph, additional, and Valent, Peter, additional

Published
2010
Full Text
View/download PDF

6. [Tumor stem cell research - basis and challenge for diagnosis and therapy].

Author

Karlic H, Herrmann H, Schulenburg A, Grunt TW, Laffer S, Mirkina I, Hubmann R, Shehata M, Marian B, Selzer E, Pfeilstöcker M, Pittermann E, Jäger U, Pehamberger H, Zielinski C, and Valent P

Subjects
Animals, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Apoptosis drug effects, Apoptosis physiology, Cell Division drug effects, Cell Division physiology, Drug Resistance, Neoplasm, Humans, Leukemia pathology, Mice, Mice, Nude, Neoplasms pathology, Neoplastic Stem Cells drug effects, Prognosis, Antineoplastic Agents therapeutic use, Leukemia diagnosis, Leukemia drug therapy, Neoplasms diagnosis, Neoplasms drug therapy, Neoplastic Stem Cells pathology, Tumor Stem Cell Assay
Abstract

Biological features of tumor cells relevant to progression, metastasis, and prognosis in cancer patients have been investigated for many years. During the past few years, the concept of tumor stem cells has gained widespread acceptance. The cancer stem cell (CSC) model is based on the observation that continuous growth of tumors depends on a small population of immature neoplastic cells with unlimited proliferative potential. In contrast to these CSC, more mature clonal cells in the same neoplasm undergo apoptosis and die after a variable number of cell divisions. The self-renewal capacity of CSC plays a central role in this scenario and enables permanent tumor cell repopulation in vivo in patients as well as in experimental animals, e.g., immunodeficient mice. Based on the stem cell concept, it is clear that the success of an anti-neoplastic approach depends on efficient targeting and elimination of CSC. An important aspect of CSC is their intrinsic resistance against conventional drugs. Therefore, a major focus in current research is molecular targets and their expression in CSC, with the goal to use targeted drugs for CSC elimination. It is the hope for the future that therapeutic approaches involving CSC-targeting concepts will lead to sustained remission and thus improvement of prognosis in leukemia and cancer patients.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results