1. A1B and BB blood group genotypes are risk factors for pulmonary embolism
- Author
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Tatjana Kereš, Jasna Bingulac-Popović, Ingrid Prkačin, Nikolina Parašilovac, Irena Jukić, Marcela Živković, Matea Vinković, Tomo Svaguša, and Ana Hećimović
- Subjects
medicine.medical_specialty ,Genotype ,Population ,030204 cardiovascular system & hematology ,Thrombophilia ,Lower risk ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,ABO blood group system ,medicine ,Humans ,030212 general & internal medicine ,education ,Blood type ,education.field_of_study ,business.industry ,General Medicine ,Venous Thromboembolism ,medicine.disease ,Pulmonary embolism ,Cross-Sectional Studies ,Blood Group Antigens ,business ,Pulmonary Embolism ,Venous thromboembolism - Abstract
Pulmonary embolism (PE) is a potentially life-threatening condition that mainly affects the people of advanced age. While certain blood group phenotypes (non‑O blood group) are known risk factors for the development of venous thromboembolism (VTE), there is no research which investigated the association of blood group genotypes with severity of PE. The aim of this study was to investigate the frequency of ABO blood group genotypes among the population of patients with PE and to investigate the correlation of the pulmonary embolism severity index (PESI) score to specific ABO blood group genotypes. In this cross-sectional study 74 patients with PE diagnosed using CT pulmonary angiography were included and 303 blood donors without VTE or congenital thrombophilia participated as a control group. After isolation of genomic DNA ABO blood group genotype was determined using the polymerase chain reaction sequence-specific amplification (PCR-SSP) method. We observed a significantly higher frequency of A1B and BB genotypes in patients with PE compared to healthy individuals (A1B 14.9% vs. 4.3%, P
- Published
- 2020