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Start Over Author "G, Schied" Journal wiener klinische wochenschrift
2 results on '"G, Schied"'

1. [Association between fibrinogen and blood sedimentation rate in combined extracorporal and fibrinogen reducing drug therapy]

Author

M, Walzl, B, Walzl, G, Schied, and H, Lechner

Subjects
Male, Fibrinogen, Blood Sedimentation, Cerebral Infarction, Middle Aged, Combined Modality Therapy, Lipoproteins, LDL, Dementia, Multi-Infarct, Double-Blind Method, Blood Component Removal, Humans, Female, Bezafibrate, Aged
Abstract

Fibrinogen appears to play an important role in atherogenesis, whereby high levels of fibrinogen can lead to a disturbance of the haemorheologic pattern. To evaluate the association between fibrinogen and blood sedimentation rate (BSR) 40 patients suffering from cerebral multi-infarct disease underwent a single heparin-induced extracorporeal LDLfibrinogenprecipitation (HELP). Subsequently they were randomly assigned to two groups, either receiving sustained-release bezafibrate 400 mg daily (n = 21) or placebo (n = 19) over a period of eight weeks. HELP led to a statistically significant reduction of fibrinogen (p0.0001). At the end of the trial the difference between the bezafibrate group and the controls became significant (p0.05). The BSR strictly followed the course of fibrinogen, indicating a significant reduction after HELP (p0.0001 for both BSR values) and a difference between both groups at the end of the study (p0.05 and p0.03, respectively). The correlation between fibrinogen and BSR remained significant during the whole trial.

Published
1993

2. [Association between fibrinogen and blood sedimentation rate in combined extracorporal and fibrinogen reducing drug therapy].

Author

Walzl M, Walzl B, Schied G, and Lechner H

Subjects
Aged, Bezafibrate adverse effects, Cerebral Infarction blood, Combined Modality Therapy, Dementia, Multi-Infarct blood, Double-Blind Method, Female, Humans, Male, Middle Aged, Bezafibrate administration & dosage, Blood Component Removal, Blood Sedimentation drug effects, Cerebral Infarction therapy, Dementia, Multi-Infarct therapy, Fibrinogen metabolism, Lipoproteins, LDL blood
Abstract

Fibrinogen appears to play an important role in atherogenesis, whereby high levels of fibrinogen can lead to a disturbance of the haemorheologic pattern. To evaluate the association between fibrinogen and blood sedimentation rate (BSR) 40 patients suffering from cerebral multi-infarct disease underwent a single heparin-induced extracorporeal LDL < fibrinogen > precipitation (HELP). Subsequently they were randomly assigned to two groups, either receiving sustained-release bezafibrate 400 mg daily (n = 21) or placebo (n = 19) over a period of eight weeks. HELP led to a statistically significant reduction of fibrinogen (p < 0.0001). At the end of the trial the difference between the bezafibrate group and the controls became significant (p < 0.05). The BSR strictly followed the course of fibrinogen, indicating a significant reduction after HELP (p < 0.0001 for both BSR values) and a difference between both groups at the end of the study (p < 0.05 and p < 0.03, respectively). The correlation between fibrinogen and BSR remained significant during the whole trial.

Published
1993

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